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franzappa

@franzappa2

Proud scientist in @Daa_lab at @Altos_labs. Interested in understanding how cells (and I) cope with stress. Membrane trafficking aficionado. 100% Italian

 San Francisco (CA)
altoslabs.com
Joined September 2018
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  • Followers503
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CCPG1 recognizes ER luminal proteins for selective ER-phagy | Molecular Biology of the Cell molbiolcell.org/doi/10.1091/…
CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy | Molecular Biology...

CCPG1 recognizes endoplasmic reticulum luminal proteins for selective ER-phagy | Molecular Biology...

CCPG1 interacts directly with endoplasmic reticulum (ER) luminal proteins, including aggregated protein. Cargo-interacting region in CCPG1 recognizes the ER luminal proteins. The ER luminal region of...

molbiolcell.org
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Fantastic work from my lovely friend and amazing scientist @nanomaddalena leveraging precision biology to show that caspase activation does not irreversibly commit cells to death. Definetely worth reading!#anastasis #PNAS pnas.org/doi/10.1073/pnas.22…
Cell survival following direct executioner-caspase activation | PNAS

Cell survival following direct executioner-caspase activation | PNAS

Executioner-caspase activation has been considered a point-of-no-return in apoptosis. However, numerous studies report survival from caspase activa...

pnas.org
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Hi 👋 science twitter! Are you into genetic screens and small molecule drug discovery? We are looking for a pharmacogenomics enthusiast! The position will be located at @altos_labs in Cambridge UK and is part of our Institute of Medicine Pls RT! boards.greenhouse.io/altosla…
Altos Labs

Altos Labs

job-boards.greenhouse.io
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5,562 proteins were found to have tissue-specific enrichment across 32 human tissues. The majority of them (3,088) are enriched at the protein but not RNA level. The brain hosts the largest number of proteins that are only enriched at the protein level but not RNA level.
Image from Prof. Nikolai Slavov (@slavov_n)
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Juan Carlos Izpisua Belmonte was recognized as the recipient of the 2022 Ogawa-Yamanaka Stem Cell Prize this week at a ceremony in San Francisco. We’re proud to see him honored for his contributions to the field.
Image from Altos Labs (@altos_labs)
Altos Labs (@altos_labs) profile pictureAltos Labs@altos_labs28 Jun 2022
Congratulations to our San Diego Institute Director Juan Carlos Izpisua Belmonte, who has been awarded this year's Ogawa-Yamanaka Stem Cell Prize by @GladstoneInst, in recognition of his innovative work on cellular rejuvenation programming! gladstone.org/news/2022-ogaw…
News and Insights | Gladstone Institutes

News and Insights | Gladstone Institutes

Gladstone Institutes news and insights on groundbreaking research, scientific discoveries, and advances in AI, genomics, neuroscience, and human health.

gladstone.org
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Why Elephants Don't Get Cancer - Scientific American scientificamerican.com/artic…
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Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing | bioRxiv___The name they gave to the libraries is the most amazing thing, love it! biorxiv.org/content/10.1101/…
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Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage | Journal of Cell Biology | Rockefeller University Press rupress.org/jcb/article/221/…
Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage

Stress granules and mTOR are regulated by membrane atg8ylation during lysosomal damage

Lysosomal damage induces stress granule (SG) formation and translational reprograming. The newly appreciated process of atg8ylation affects SG formation an

rupress.org
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NEW ONLINE: Differential ribosomal gene RPL22L1 splicing isoforms are generated in response to acidification of the glioblastoma core to regulate cell stemness and survival and increase tumour heterogeneity. PDF: rdcu.be/cWT8a nature.com/articles/s41556-0…
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Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify autophagosome initiation sites cell.com/cell/fulltext/S0092…
Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify...

Calcium transients on the ER surface trigger liquid-liquid phase separation of FIP200 to specify...

Autophagy stimuli trigger Ca2+ transients/oscillations on the outer surface of the ER membrane, which induce phase separation of FIP200 for specification of autophagosome initiation sites on the ER....

cell.com
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Please spread the news… we are going to recruit 3 PhD students on our ERC funded project lipotrace!!! So if interested in time resolved single cell lipidomics join us at EPFL ;) – at Ecublens (VD), Suisse
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ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains cell.com/developmental-cell/…
ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid...

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid...

Anwar et al. show that organization of the plasma membrane into nanodomains, which are required for anthrax intoxication, depends on the transfer of cholesterol at sites where the endoplasmic...

cell.com
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We have been selected as one of @JohnCendpts' 11 most promising startups in the biotech industry. We're thrilled to have been able to bring together a fantastic team to advance our shared mission and are excited to see what the future holds endpts.com/the-endpoints-11-…
The Endpoints 11: The top private biotechs in pursuit of new drugs. Pushing the envelope with...

The Endpoints 11: The top private biotechs in pursuit of new drugs. Pushing the envelope with...

Right around the beginning of the year, we got a close-up look at what happens after a boom ripples through biotech. The crash of life sciences stocks in Q1 was ...

endpoints.news
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Our structure of dynein-dynactin on microtubules is now out in @Nature! Thanks to @janetiwasa for this beautiful movie showing how cargos might use pairs of adaptors to recruit their motors. nature.com/articles/s41586-0…
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Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses: Cell Reports cell.com/cell-reports/fullte…

Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses

Luo et al. report a noncanonical function of ATG9A in regulating Golgi dynamics. Under heat stress, ATG9A is ubiquitinated by MARCH9 and interacts with GRASP55 to impair its Golgi stacking ability,...

cell.com
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Monitor autophagic flux in mammalian cells easily with our new method, now out in @eLife! Pulse-labeled HaloTag reporters are processed in lysosomes, releasing proteolysis-resistant labeled Halo. Free labeled Halo amount = autophagic flux! →western/in-gel fluo/microsc./flow cyto
Image from Mizushima Lab (UTokyo) (@MizLabUT)
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Super cool story! embopress.org/doi/full/10.15…
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Chaperone-Directed Ribosome Repair after Oxidative Damage | bioRxiv biorxiv.org/content/10.1101/…
Chaperone-Directed Ribosome Repair after Oxidative Damage

Chaperone-Directed Ribosome Repair after Oxidative Damage

Reactive oxygen species are ubiquitous in cells, where they damage RNA and protein. While relief mechanisms, including effects on translation, have been described, whether ribosomes are functionally...

biorxiv.org
De novo RNA tertiary structure prediction at near-atomic resolution using deep learning: DeepFoldRNA significantly outperforms state-of-the-art! If it indeed works, it would be a huge leap forward in RNA structure prediction! biorxiv.org/content/10.1101/…
De Novo RNA Tertiary Structure Prediction at Atomic Resolution Using Geometric Potentials from Deep...

De Novo RNA Tertiary Structure Prediction at Atomic Resolution Using Geometric Potentials from Deep...

Experimental characterization of RNA structure remains difficult, especially for non-coding RNAs that are critical to many cellular activities. We developed DeepFoldRNA to predict RNA structures from...

biorxiv.org
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Selective inhibition of protein secretion by abrogating receptor–coat interactions during ER export | PNAS pnas.org/doi/10.1073/pnas.22…
Selective inhibition of protein secretion by abrogating receptor–coat interactions during ER export...

Selective inhibition of protein secretion by abrogating receptor–coat interactions during ER export...

Protein secretion is an essential process that drives cell growth, movement, and communication. Protein traffic within the secretory pathway occurs...

pnas.org
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