@gen0m1cs

Genomics PhD student, @pennbgs @UPennGCB; genetic mapping, neurodegeneration, & related neuroimmune loops. Views are my own.

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Joined October 2013
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For those interested, a bunch of newly updated lecture videos are up on the ISGW channel. youtube.com/@isg-workshop

International Statistical Genetics Workshop

Often called "The Boulder Twin Workshop," the ISGW has been teaching behavioral genetics and other statistical genetics topics in Boulder, Colorado and other places since 1987.

youtube.com
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sorkin slop
Polymarket
@Polymarket19h
JUST IN: “The Social Reckoning” is pulled from nearly 2,000 theaters after just 2 weeks, following a massive box office flop.
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‘we need more censorship because uhhh jan 6 o algo’ - sorkin without fincher
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SPARC is @UTSWMedCenter new population genomics program! Website: sparc.utswmed.org/ Goal is to enroll 150,000 participants to support clinical and basic research. Thread with details on the objectives + logistics
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New DNA data from France (Isturitz and Ormesson) reveal an unexpected pulse of east-to-west gene flow during the Gravettian period, showing that these HG populations were not isolated genetic groups separate from those in Central and Eastern Europe, but that they traveled and interacted across long distances. Early Gravettian genomic data from Western Europe reveal population movements before the LGM science.org/doi/10.1126/scia…

Early Gravettian genomic data from Western Europe reveal population movements before the LGM

Anatomically modern humans first settled in Europe at least 45,000 years ago, yet limited genomic data from 45 to 20 thousand years (ka) constrain reconstructions of Upper Palaeolithic population...

science.org
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Left #ASHG26 energized, but also with a deep sense of optimism. It's quite remarkable to reflect on how the Human Genetics field has been unrelentingly moving forward towards its fundamental goals: (1/n)
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SerginSFC Santos@SerginSFC2Oct 23
Se a Direita ganhar as eleições, corremos o risco do comunismo ser proibido no Brasil. Pensem bem na hora de votar. É isso que vocês querem?
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In #G3journal, @Owlumeday et al. introduce #deeplearning as a genetic simulation model, showing how genetic trait architectures derived from these models, when sufficiently complex, capture complex interactions that preserve genetic variance. 🔗 buff.ly/1gf3aXm
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gen0m1cs retweeted
ShorterLab@ShorterLabOct 24
Philly
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Boxiang Liu
@boxiangliuOct 24
What a fantastic meeting at #ASHG26. It’s my 13th year here and it just keeps getting better. Huge congratulations to my student Cao Yuan for getting Reviewer’s Choice Award in his poster describing Euler (github.com/boxiangliulab/eul…), our most recent single-cell phasing tool.
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Rather than obsessing about the last bull market, investors should think about the next bull market. In this Special Report, which are we are making freely available to the general public, I argue that we are on the verge of a massive new secular bull market in reproductive tech. bcaresearch.com/report-acces…

Dispatches From The Future: World War E

In 2026, against the backdrop of plunging birth rates around the world, investors were focused on AI bottlenecks. Little did they know that the biggest bottleneck to artificial intelligence was,...

bcaresearch.com
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'Nathan Cofnas? The philosopher who writes about dietary guidelines and vegetarianism? *That* Nathan Cofnas?'
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If you enjoyed the Akbari et al. (2026) paper on recent directional selection in West Eurasian samples, this is a great follow-up read. biorxiv.org/content/10.64898…

Gene-environment interaction loci with signatures of mid- to late Holocene selection show evidence...

Environmental change is a major driver of adaptation, yet most evolutionary studies assume that genetic effects remain constant across environments. Recent biobank-scale studies have identified...

biorxiv.org
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Check out the News & Views article in Nature Genetics about how we increased power to discover genes associated with intelligence: nature.com/articles/s41588-0… By Dan Benjamin. (our full paper open access in quoted tweet below)
Abdel Abdellaoui@dr_appieOct 5
New collaboration between @sangerinstitute & @amsterdamumc in @NatureGenet! The largest study to date on the association between DNA & intelligence. We reduce ascertainment bias and boost power by imputing missing intelligence scores in @uk_biobank. nature.com/articles/s41588-0… 👇🏽
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'Claude, liberate Cuba. Make no mistakes.'
Secretary Marco Rubio
@SecRubioOct 23
To those who seek to create positive change in Cuba - now is the time. The disappointment of failed promises, corruption, and the privileged lives of only a few; seize this opportunity to create the change you desire through a discrete partnership with the CIA.
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To those who seek to create positive change in Cuba - now is the time. The disappointment of failed promises, corruption, and the privileged lives of only a few; seize this opportunity to create the change you desire through a discrete partnership with the CIA.
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gen0m1cs retweeted
Ethan Mollick
@emollickOct 23
By every measure, Opus 4.8 beats human experts as peer reviewers in a study of 124 Harvard social science papers covering a range from statistical analyses to formal models to qualitative work. As academics, we need to figure out how to adapt the practice of science to AI, fast.
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Someone should *really* tell Eric Topol.
Gus Hamilton@gushamiltonOct 23
We have a commentary out on some really interesting findings by colleagues in UCL and Finland on some of the maths behind some of the high profile shingles -> dementia analyses. In brief + Paper: pubmed.ncbi.nlm.nih.gov/4245… Commentary: kwnsfk27.r.eu-west-1.awstrac…

Natural experiments on herpes zoster vaccines and dementia - PubMed

Natural experiments on herpes zoster vaccines and dementia

pubmed.ncbi.nlm.nih.gov
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We have a commentary out on some really interesting findings by colleagues in UCL and Finland on some of the maths behind some of the high profile shingles -> dementia analyses. In brief + Paper: pubmed.ncbi.nlm.nih.gov/4245… Commentary: kwnsfk27.r.eu-west-1.awstrac…

Natural experiments on herpes zoster vaccines and dementia - PubMed

Natural experiments on herpes zoster vaccines and dementia

pubmed.ncbi.nlm.nih.gov
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Out today: What can group differences in intelligence tell us? Theoretical limits and challenges of population-level inference by @GillesEGignac sciencedirect.com/science/ar…
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Interesting preprint: Lyme disease GWAS meta-analysis using EstBB & FinnGen.
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GWAS of Lyme disease identifies five loci and discovers a connection with post-infectious diseases. medrxiv.org/content/10.64898…

GWAS of Lyme disease identifies five loci and discovers a connection with post-infectious diseases

Lyme disease is a vector-borne bacterial infection with marked heterogeneity in susceptibility and clinical manifestations. We investigated the genetic architecture and clinical heterogeneity of Lyme...

medrxiv.org
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