@jan_lanzer

MD/PhD @saezlab, with interest in computational biology and cardiology https://xitter.cf/t.co/k2o8CSMATp

Joined February 2021
  • Tweets48
  • Following305
  • Followers150
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Glad to share this online: we’ve expanded our transcriptomics meta-analysis of heart failure to the multicellular level. Check out how you can use this reference to support your own data analysis! This was another rewarding team effort w @roramirezf94 #HeartFailure
Saez-Rodriguez Group@saezlab11 Nov 2024
What are the key disrupted multicellular processes in heart failure? In our new work we combine 23 years of molecular data with recent single-cell atlases to draw a cross-study patient map. How did we navigate the heart failure space? 🧵⬇️ doi.org/10.1101/2024.11.04.6…
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Jan Lanzer retweeted
EMBL-EBI@emblebi4 Feb 2025
Organoids have incredible potential in drug discovery and disease modelling. In this Scientific Computing World interview, @Iguaracysousa discusses organoid construction, nanobots, and how bioinformatics is transforming biomedical research. scientific-computing.com/art…
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We are looking for a PostDoc with strong computational expertise to join our lab with a focus on computational tissue biology: karriere.klinikum.uni-heidel…
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We use Multiome and HiC to build a comprehensive single cell variant to enhancer to gene map for coronary artery disease. Join effort with @PaulChungrohLee and IttaiEres in Nate Stitziel Lab and in collaboration with @Amgen @WUSTLmed medrxiv.org/content/10.1101/…

Single cell variant to enhancer to gene map for coronary artery disease

Although genome wide association studies (GWAS) in large populations have identified hundreds of variants associated with common diseases such as coronary artery disease (CAD), most disease-associa...

medrxiv.org
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Excited to share our study on spatio-temporal reconstruction of cardiac scar formation led by @ChanAndyson. We combine scRNA-seq with spatial transcriptomics to resolve the fibrotic niche and the niche of dedifferentiating cardiomyocytes. biorxiv.org/content/10.1101/…
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Our work with @schirmerlab in multiple sclerosis (MS) is out today in @NatureNeuro. We investigated lesion progression and cell-cell communication events in MS using snRNA-seq and spatial transcriptomics 🧠 See below ⬇️ nature.com/articles/s41593-0…
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📢 Introducing CORNETO: a unified, knowledge-driven framework for multi-sample network learning & modeling via constrained optimization, supporting a wide variety of network methods and prior knowledge 💻Code: github.com/saezlab/corneto 📜Paper: doi.org/10.1101/2024.10.26.6… 🧵👇
CORNETO: Unified knowledge-driven network inference from omics data

ALT CORNETO: Unified knowledge-driven network inference from omics data

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Are you interested in sc-spatial multiomics data, motivated by improving patient outcomes in lung cancer, and keen to join a young and growing lab taking single-cell atlassing to clinical applications? Please apply :). We're looking for Postdocs! jobs.helmholtz-muenchen.de/j…
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Check out our work on fibroblast activation patterns in HF models! Huge thanks to my co-lead @LauraWienecke 🙏 from @LeuschnerLab!
Leuschner Lab@LeuschnerLab25 Sep 2024
scRNA-Seq profiling of 🫀interstitial cells reveals fibrosis in HFpEF to be distinct from HFrEF including the induction of basement membrane collagens and a protective ⬆️ of ANGPTL4 in murine and human HFpEF | led by @LauraWienecke and @jan_lanzer doi.org/10.1007/s00395-024-0…

Single-cell transcriptomics reveal distinctive patterns of fibroblast activation in heart failure...

Basic Research in Cardiology - Inflammation, fibrosis and metabolic stress critically promote heart failure with preserved ejection fraction (HFpEF). Exposure to high-fat diet and nitric oxide...

link.springer.com
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🚨 We are looking for a PhD student 🚨 to join the Tanevski Lab and @DenisSchapiro Lab at the Heidelberg University Hospital, working at the intersection of machine learning and spatial omics as part of the Translational Spatial Profiling Center. Please RT karriere.klinikum.uni-heidel…
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Congrats Julio!!
EMBL-EBI@emblebi2 May 2024
Replying to @emblebi
We welcome Julio Saez-Rodriguez @JulioSaezRod as our new Head of Research! Associate Director for EMBL-EBI Services Jo McEntyre @jomcentyre has been promoted to Deputy Director of EMBL-EBI & Rolf Apweiler is stepping back to Associate Director as he looks towards retirement.
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Jan Lanzer retweeted
EMBL-EBI@emblebi2 May 2024
We welcome Julio Saez-Rodriguez @JulioSaezRod as our new Head of Research! Associate Director for EMBL-EBI Services Jo McEntyre @jomcentyre has been promoted to Deputy Director of EMBL-EBI & Rolf Apweiler is stepping back to Associate Director as he looks towards retirement.
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See this great perspective by @roramirezf94 and others on multicellular processes and how to study them using single cell omics!
Saez-Rodriguez Group@saezlab18 Mar 2024
How to link single-cell diversity and the emergence and maintenance of robust multicellular processes in developed tissues? 🤔 What can we learn about multicellular coordination in tissues from single-cell omics data? Read about our view: arxiv.org/abs/2403.06753
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1) Are you interested in computational approaches to study the immune system 🔎🦠by integrating single-cell + spatial multi-omics data with prior knowledge? Check our review 📖out now in @NatImmunol nature.com/articles/s41590-0… 🧵
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Our @jan_lanzer will present his work (together w @roramirezf94) on multicellular programs in heart failure at #EMBOCardioBiology this week. Come find him if you are interested in how we can leverage public single cell atlases to study coordinated events in myocardial remodeling
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Super excited to organize a local site for this @nf_core hackathon with @kubranarci in Heidelberg. Hoping to see many of you code some @nextflowio with us there 🤩✨🧑‍💻!
Chris Hakkaart@Chris_Hakk16 Jan 2024
🗓️ Mark your calendars ✏️ The @nf_core hackathon is locked in for March 18-20. Local sites are back again. Get in touch if you are thinking about hosting or want to know more 🌎🌍🌏
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Multicellular Factor Analysis is now fully available in @eLife's website, including the editor's evaluation and our updated revision. Estimate multicellular programs and perform unsupervised analysis of samples from cross-condition single cell atlases elifesciences.org/articles/9…
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🧬Explore disease at a multicellular level, capturing variations in patient samples across cell types, tissue features, studies, and technologies with Multicellular Factor Analysis, peer-reviewed by @ReviewCommons and now published @eLife elifesciences.org/articles/9…
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Thx @ERC_Research for funding our #ERCSyG project w @ejvillablanca @ZellerGroup @giacomello_lab 🙏. Looking fwd to synergizing our expertise in immunology, #spatial techs, microbiome🦠 & computational modeling💻 to study gut host-microbiome interactions in health & disease
European Research Council (ERC)
@ERC_Research26 Oct 2023
📣 Results of the 2023 ERC Synergy Grant competition are out! 37 research groups win a total of €395 million in #ERCSyG funding 👉 This will enable them to pool diverse expertise and resources to push the frontiers of knowledge. Full story: europa.eu/!JVYxjm 🇪🇺#EUfunded
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Check out our new preprint🥳 We focused on using #gutmicrobiome 🦠data to predict heart 🫀failure risk with @erawijantaript @openreslabs @JulioSaezRod @saezlab @LevinsonLab...
Saez-Rodriguez Group@saezlab16 Oct 2023
🧬 Exciting Preprint Alert! 🚀 Heart failure is a pressing public health issue. Can microbiome data help us predict heart failure risk and uncover its biology🦠? Read the preprint for all the details 📚 medrxiv.org/cgi/content/shor… 🔬and in a nutshell
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