Hyunglok Chung (@lokhee7) header
Hyunglok Chung (@lokhee7) profile picture

Hyunglok Chung

@lokhee7

Where are you going, lipids? | Asst. Prof. at Houston Methodist Research Institute | Weill Cornell Medical College

 Houston, TX
chung.hmailabs.org/
Joined March 2019
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  • Following227
  • Followers147
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Photo by Hyunglok Chung (@lokhee7)Photo by Hyunglok Chung (@lokhee7)
Our paper on cdk8/CDK19 with great collaborators Jenny and @EstherVerheyen has finally been published in Nature Communications after a long revision process (one and a half years). Please check it out !👇
Dr. Esther Verheyen (@EstherVerheyen) profile pictureDr. Esther Verheyen@EstherVerheyen18 Apr 2024
Delighted to share our paper that was published today - great collaboration between my lab and Hyung-lok Chung (@lokhee7), Hugo Bellen, Oguz Kanca and others. This has been a huge achievement for my PhD student Jenny Liao and technician Claire Shih. 🎉🍾 nature.com/articles/s41467-0…
Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically...

Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically...

Nature Communications - Mitochondrial fission, performed by Drp1, is carefully regulated, particularly in neurons. Here, the authors examine Drosophila Cdk8/CDK19 function in mitochondrial fission...

nature.com
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Celebrating a year of hard work with the Chung Lab team and our amazing summer interns! Grateful to be part of such a talented and dedicated group. Excited for what’s ahead!
Image from Hyunglok Chung (@lokhee7)
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Our researcher Dr. @lokhee7 has unveiled a novel function of the cyclin-dependent kinase protein CDK19, a potential target for the prevention and treatment of Parkinson's and other disorders of the nervous system. spr.ly/6017gSBqX
Uncovering a New Role for CDK19 in Rare and Common Diseases

Uncovering a New Role for CDK19 in Rare and Common Diseases

A Houston Methodist researcher discovers a novel function of the cyclin-dependent kinase protein CDK19, highlighting its role in mitochondrial dynamics.

houstonmethodist.org
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Replying to @lokhee7 @EstherVerheyen
Thank you for great support @HMethodistMD @MethodistHosp !
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Great news! Jenny and Esther's endeavor was huge. It was indeed an epic journey as a team. Stay tuned.
Dr. Esther Verheyen (@EstherVerheyen) profile pictureDr. Esther Verheyen@EstherVerheyen8 Apr 2024
Accepted! Finally...! This has been an epic journey (over 1.5 years). More details to follow... Biggest congrats to co-first authors Jenny Liao and @lokhee7 and my wonderful co-corresponding colleague Hugo Bellen. 🎉🍾
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I am grateful to be a part of Houston Methodist, which provides excellent research support and fosters dynamic collaborations between clinicians and researchers. Stay tuned for exciting translational research using fly model!
Houston Methodist MD (@HMethodistMD) profile pictureHouston Methodist MD
@HMethodistMD13 Mar 2024
Our researcher Dr. @lokhee7 utilizes fruit fly models to diagnose and develop therapeutics for rare human diseases, such as Mitchell syndrome. Read more on Leading Medicine: spr.ly/6017Xaekb
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Great! It should be an exciting talk!
Dr. Esther Verheyen (@EstherVerheyen) profile pictureDr. Esther Verheyen@EstherVerheyen9 Feb 2024
Looking forward to presenting our @CIHR-funded work in collaboration with @lokhee7 and Hugo Bellen's group on Cdk8/CDK19 at their modulation of mitochondrial dynamics at the #KSMitochondria24 symposium in Banff next week!
Image from Dr. Esther Verheyen (@EstherVerheyen)
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Congrats, Hugo!
The GruberFoundation (@The_Gruber_Fdtn) profile pictureThe GruberFoundation@The_Gruber_Fdtn17 Jan 2024
Congratulations to Hugo J. Bellen, recipient of the 2024 Gruber Genetics Prize! @GeneticsGSA @bcmhouston gruber.yale.edu/prize/2024-g…
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Hyunglok Chung retweeted
Oded Rechavi (@OdedRechavi) profile picture
Oded Rechavi
@OdedRechavi6 Sep 2023
Everyone wants scientists to dare and think big but the career advice scientists actually get are always super risk averse: "make sure you pass the committee in flying colors" (so break your story down to small papers, don't set difficult goals in your research proposal, etc.)
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Thank you for this interview and nice summary! @HMethodistMD, @MethodistHosp read.houstonmethodist.org/fr…
From The Humble Fly, Great Discoveries Are Made

From The Humble Fly, Great Discoveries Are Made

Hyunglok Chung, PhD, has found the Drosophila fruit fly a key partner in discovering ultra-rare and previously unknown diseases, as well as developing new treatments.

houstonmethodist.org
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So, in our recent editorial, @cleaverlab, @Lab_VPrince, and I pointed out the obvious: WE are the ones letting peer review destroy the future of academic biology. So, what can we do differently? Here's one idea in a very short 🧵 1/6 sciencedirect.com/science/ar…
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It was a wonderful meeting with great people discussing Mitchell Syndrome at Houston Methodist.
The Mitchell and Friends Foundation (@MtlSyndrome) profile pictureThe Mitchell and Friends Foundation@MtlSyndrome5 Jun 2023
mitchellandfriends.org/blog/…
First Ever Mitchell Syndrome Summit — The Mitchell and Friends Foundation

First Ever Mitchell Syndrome Summit — The Mitchell and Friends Foundation

The First Ever Mitchell Syndrome Summit was held on June 1-2 at Houston Methodist Hospital in Texas.

mitchellandfriends.org
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mitchellandfriends.org/blog/…
First Ever Mitchell Syndrome Summit — The Mitchell and Friends Foundation

First Ever Mitchell Syndrome Summit — The Mitchell and Friends Foundation

The First Ever Mitchell Syndrome Summit was held on June 1-2 at Houston Methodist Hospital in Texas.

mitchellandfriends.org
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It was a GREAT meeting. Thank you so much for visiting us and also for your support of our research! @MtlSyndrome
FOX26Houston (@FOX26Houston) profile pictureFOX26Houston
@FOX26Houston1 Jun 2023
Just over 20 people in the world have been diagnosed with the rare genetic mutation, Mitchell Syndrome, and most of them have been children. fox26houston.com/news/mitche…
Four families raise $25K for Mitchell Syndrome research but what is it?

Four families raise $25K for Mitchell Syndrome research but what is it?

Just over 20 people in the world have been diagnosed with the rare genetic mutation, Mitchell Syndrome, and most of them have been children.

fox26houston.com
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Mitchell Syndrome patients and families hope for new treatments after raising $25,000 (fox26houston.com) #MitchellSyndrome #RareDisease #HoustonMethodistHospital #Research #HoustonMethodistNeurology
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Hyunglok Chung retweeted
FOX26Houston (@FOX26Houston) profile picture
FOX26Houston
@FOX26Houston1 Jun 2023
Just over 20 people in the world have been diagnosed with the rare genetic mutation, Mitchell Syndrome, and most of them have been children. fox26houston.com/news/mitche…
Four families raise $25K for Mitchell Syndrome research but what is it?

Four families raise $25K for Mitchell Syndrome research but what is it?

Just over 20 people in the world have been diagnosed with the rare genetic mutation, Mitchell Syndrome, and most of them have been children.

fox26houston.com
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Hyunglok Chung retweeted
The Nobel Prize (@NobelPrize) profile picture
The Nobel Prize
@NobelPrize19 May 2023
Do you recognise this Drosophila fly from your kitchen? There are over 1,500 species of Drosophila, and one of these is among biomedical science’s most important model organisms. Learn more: nobelprize.org/drosophila/
Image from The Nobel Prize (@NobelPrize)
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I am privileged to be the first-first author in @Cell_Metabolism @NeuroCellPress @Dev_Cell @AJHGNews using Drosophila model. Thank you, Cell Press. Now, I have started my lab & am hiring two Postdocs! cell.com/neuron/fulltext/S08… cell.com/developmental-cell/… cell.com/ajhg/fulltext/S0002…

Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms

Chung et al. show that ACOX1, a peroxisomal protein required for degrading VLCFA, is mostly expressed in glial cells. Its loss causes an accumulation of VLCFA and glial loss. An ACOX1 gain-of-funct...

cell.com
Cell Metabolism (@Cell_Metabolism) profile pictureCell Metabolism@Cell_Metabolism20 Apr 2023
New! Online now: Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and neuroinflammation dlvr.it/Smq1Zp
Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and...

Very-long-chain fatty acids induce glial-derived sphingosine-1-phosphate synthesis, secretion, and...

During demyelination and aging, glia are exposed to myelin components that contain high levels of VLCFAs. Here, Chung and Ye et al. document that VLCFA accumulation increases sphingosine-1-phosphate...

cell.com
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We will explore the role of lipid metabolism in neuroinflammation & also further help diagnose and therapeutics for rare-common disease patients using our amazing fly model ! Please DM me or email [email protected] for any inquiries or more information.
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#Dros23 Fly meeting is such a wonderful opportunity to see old friends and collaborators - fun chat with Allan Spradling and Hugo Bellen. Realized I first met Allan in 1990 when I helped with the big P-element screen at Carnegie while in Lynn Cooley's lab.
Image from Dr. Esther Verheyen (@EstherVerheyen)
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