PI - Neuropsychiatric Genomics Laboratory @ IMH; Deputy Scientific Director PRECISE-SG100K National Precision Medicine Initiative
Singapore
Joined November 2016
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📚 Our findings contribute to a deeper understanding of schizophrenia biology and pave the way for more targeted therapies and interventions. Stay tuned for updates on our cognitive genomics research! #Schizophrenia #Pleiotropy #MedRxiv #NIMH
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🔬 Our new results dissociate forebrain and hindbrain neurodevelopmental processes, and implicate translation initiation factors in schizophrenia pathophysiology for the first time.
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🧠 Our study sheds light on the biological underpinnings of schizophrenia, leveraging pleiotropy with cognitive ability and educational attainment to reveal distinct neurodevelopmental and synaptic pathways involved in the disorder's etiology.
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🧬 New preprint alert! Our latest manuscript on MedRxiv investigates the complex pleiotropic genetic landscape of schizophrenia, cognitive function and educational attainment uncovering 768 significant loci – 159 of which are novel. medrxiv.org/content/10.1101/… @ToddLencz
Max Lam retweeted
We are looking forward to 2024 WCPG in Singapore (15th-19th Oct). In the words of our 2024 Program Chairs, "These are exciting times in psychiatric genetics."
Want to learn more? Check out the 2024 invitation to attend: ispg.net/wcpg-2024-invitatio…
#psychiatry #genetics
Max Lam retweeted
Deconstructing the genetic architecture of treatment-resistant schizop... sciencedirect.com/science/ar…
@maxzylam @KeaneLim
Max Lam retweeted
🤩 OUT TODAY @NatureGenet
📰 The Singapore National Precision Medicine Strategy
👩🏾🤝👨🏽 John C. Chambers, E. Shyong Tai, Patrick Tan and team
👇🏿🇸🇬🧬👇🏿
go.nature.com/3ZZb186
Max Lam retweeted
Pleased to announce the launch of:
polygenicembryo.org
The website of the Polygenic Embryo ELSI Research (PEER) Group
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Max Lam retweeted
Our latest preprint: a novel cross-ancestry fine-mapping method with much improved power and calibration. A collaboration with @kaiyuan1990 @RyanLongchamps @AFPopgen @getian107 @ChiayenChen @YenFengLin @bmneale @dalygene @PGCgenetics among others! medrxiv.org/content/10.1101/…
Max Lam retweeted
Glad to share this manuscript doi.org/10.1038/s41380-022-0… which is finally out in @molpsychiatry. Previous studies identified immune gene dysregulations in the brains of patients with several major brain disorders. (1/7)
A big thank you and shout out to @ToddLencz @ChiayenChen @getian107 @hailianghuang for their valuable insights and help on this effort!
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The results might provide insights into the potential of nootropic agents targeting specific biological mechanisms to alleviate functional disability within psychopathology. (8/8)
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We also show that CTP meta-loci indexing neurodevelopmental mechanisms also tend to collocate in specific spatial gene expression in the brain (Allen Brain Atlas) – e.g., CTP-15 genes would index Axon Development; collocated to the parahippocampal region of the brain. (7/8)
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Mechanism: e.g., NCF Meta-Locus 2, implicates several GABA receptor genes + transporter SLC6A1, suggesting the possibility that GABA-ergic treatment approaches may enhance NCF while ameliorating the correlated affective and anxiety symptoms that load on this meta-locus. (6/8)
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Meta-loci for CTP harbored genes that tended to be neurodevelopmental and expressed prenatally, while genes specific to NCF meta-loci were related to synaptic processes and regulation. This supports and extends the results of our earlier research sciencedirect.com/science/ar…
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The cognitive data was reduced to two primary dimensions: Cognitive Task Performance (CTP) and Non-Cognitive Factor (NCF). We worked with the editorial team to update the appropriateness of terminology describing such cognitive dimensions - (4/8)
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