Max Lam (@maxzylam) header
Max Lam (@maxzylam) profile picture

Max Lam

@maxzylam

PI - Neuropsychiatric Genomics Laboratory @ IMH; Deputy Scientific Director PRECISE-SG100K National Precision Medicine Initiative

 Singapore
researchgate.net/profile/Max_Lam2
Joined November 2016
  • Tweets52
  • Following510
  • Followers229
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Photo by Max Lam (@maxzylam)Photo by Max Lam (@maxzylam)Photo by Max Lam (@maxzylam)Photo by Max Lam (@maxzylam)Photo by Max Lam (@maxzylam)Photo by Max Lam (@maxzylam)
Max Lam retweeted
ISPG (@ISPGnet) profile picture
ISPG@ISPGnet5 Feb 2024
We are looking forward to 2024 WCPG in Singapore (15th-19th Oct). In the words of our 2024 Program Chairs, "These are exciting times in psychiatric genetics." Want to learn more? Check out the 2024 invitation to attend: ispg.net/wcpg-2024-invitatio… #psychiatry #genetics
Image from ISPG (@ISPGnet)
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Deconstructing the genetic architecture of treatment-resistant schizop... sciencedirect.com/science/ar… @maxzylam @KeaneLim
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🤩 OUT TODAY @NatureGenet 📰 The Singapore National Precision Medicine Strategy 👩🏾‍🤝‍👨🏽 John C. Chambers, E. Shyong Tai, Patrick Tan and team 👇🏿🇸🇬🧬👇🏿 go.nature.com/3ZZb186
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Pleased to announce the launch of: polygenicembryo.org The website of the Polygenic Embryo ELSI Research (PEER) Group (1/5)

Home | Polygenic Embryo ELSI Research Group

The 'PEER' Group is a team of researchers based at Harvard Medical School, Baylor College of Medicine, Hofstra University, and The Hebrew University of Jerusalem. The PEER Group investigates the...

polygenicembryo.org
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Our latest preprint: a novel cross-ancestry fine-mapping method with much improved power and calibration. A collaboration with @kaiyuan1990 @RyanLongchamps @AFPopgen @getian107 @ChiayenChen @YenFengLin @bmneale @dalygene @PGCgenetics among others! medrxiv.org/content/10.1101/…
Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying...

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying...

Genome-wide association studies (GWAS) of human complex traits or diseases often implicate genetic loci that span hundreds or thousands of genetic variants, many of which have similar statistical...

medrxiv.org
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Image from Todd Lencz (@ToddLencz)
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Glad to share this manuscript doi.org/10.1038/s41380-022-0… which is finally out in @molpsychiatry. Previous studies identified immune gene dysregulations in the brains of patients with several major brain disorders. (1/7)
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Opening of the 2nd Pan-Asia Symposium on the Genetics of Brain Disease in Singapore, with call for action from Steve Hyman to uncover the biological mechanisms for psychiatric disorders to kickstart new drug discovery
Image from Dr Cathryn Lewis (@cathrynlewis)
Image from Dr Cathryn Lewis (@cathrynlewis)
Image from Dr Cathryn Lewis (@cathrynlewis)
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Colonization in science hurts our study participants, builds a collaborative culture that is toxic and not sustainable, destroys the public trust in us, and eventually hurts the science.
Hailiang Huang (@hailianghuang) profile pictureHailiang Huang@hailianghuang13 Sep 2022
Look forward to joining this extremely important discussion! To me, colonization in science is the extraction of scientific knowledge in a manner that exploits study participants and researchers, often through a power imbalance. @ISPGnet
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Proud to share this work @ConversationUS, with @sineadbchapman, @CorieLok, @scribbler_tom, @rosyhosking at @broadinstitute & @StanleyCenter: Uncovering the genetic basis of mental illness requires data and tools that aren’t just based on white people tinyurl.com/bd86h3rr
Uncovering the genetic basis of mental illness requires data and tools that aren’t just based on...

Uncovering the genetic basis of mental illness requires data and tools that aren’t just based on...

Existing genetic data and sequencing tools are overwhelmingly based on people of European ancestry, which excludes much of the rich genetic variation of the world.

theconversation.com
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Our GWAS of Executive Functioning (EF) in ~427,000 individuals is now online at Biological Psychiatry. A thread on incites into cognition and psychiatric genetics. biologicalpsychiatryjournal.… (1/8) #PsychTwitter, #GABA, #NeuroTwitter, #GWAS, #cognition, #neuropsychology, #Psychiatry
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New preprint! We studied how rare protein-coding variants impact cognitive function & linked diseases in @uk_biobank. We identified 8 large-effect cog fx genes, dosage-sensitivity for KDM5B, additivity of rare variant and polygenic risk & more (1/12) medrxiv.org/content/10.1101/…
The impact of rare protein coding genetic variation on adult cognitive function

The impact of rare protein coding genetic variation on adult cognitive function

Compelling evidence suggests that cognitive function is strongly influenced by genetics. Here, we conduct a large-scale exome study to examine whether rare protein coding variants impact cognitive...

medrxiv.org
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Our latest cognitive GWAS from the COGENT consortium is out (and open!) in @npp_journal nature.com/articles/s41386-0… In addition to our largest sample size (N = 373,617), we use novel transcriptomic and chemoinformatic tools to identify gene targets for nootropic repurposing.@ACNPorg
Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

Neuropsychopharmacology - Identifying nootropic drug targets via large-scale cognitive GWAS and transcriptomics

nature.com
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By studying schizophrenia in the Ashkenazi Jewish founder population, @ToddLencz & coll. identified rare severe alleles shared by a few patients implicating cadherins Read this 👉bit.ly/3bhnZ9x & its preview by Jon McClellan & Mary-Claire King bit.ly/2QdPUjm
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Delighted to share our latest preprint: the largest analysis assessing the contribution of rare genetic variants to the risk of depression, based on the exomes from 320,356 @uk_biobank participants medrxiv.org/content/10.1101/…
Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major...

Whole exome sequencing in the UK Biobank reveals risk gene SLC2A1 and biological insights for major...

Nearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS)[1][1]–[4][2]. However, the impact of rare coding variants on depression remains...

medrxiv.org
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Max Lam retweeted
Ensembl (@ensembl) profile picture
Ensembl@ensembl29 May 2018
Large #GWAS with data from @uk_biobank, CHARGE & COGENT consortia finds 148 loci associated with general cognitive function #UsingEnsembl @ccace @NatureComms buff.ly/2LCd9MK
Image from Ensembl (@ensembl)
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