Michael Pitcher retweeted
A new Science #Immunology study identified the distribution and immune interactions of immunomodulatory B cells in the human #appendix, and shows that they are disrupted during ulcerative #colitis. @JoSpencerLab scim.ag/4uaQiff
Michael Pitcher retweeted
Immunomodulatory B cells in human gut-associated lymphoid tissue support mucosal homeostasis
science.org/doi/10.1126/scii… @SciImmunology @michaeljpitcher @JoSpencerLab @KingsCollegeLon
Michael Pitcher retweeted
We’re excited to share that PharosAI has selected our Xenium spatial platform to help build a multimodal cancer dataset, an initiative that brings together academic and NHS partners to transform archived cancer samples into high-res, AI-ready data. bit.ly/4aeP6zJ
Michael Pitcher retweeted
Could tolerance to DNA be broken in the gut in systemic lupus erythematosus?
In our latest review we explore whether tolerance to DNA can be broken when undigested DNA from microbiota in GALT directly encounters B cells unrestricted by T cell dependence
doi.org/10.1016/j.imlet.2024…
Michael Pitcher retweeted
After leaving the bone marrow, transitional B cells split into subsets w/ biased expression of homing receptors and different surface IgM levels. Spencer & Dionisi @JoSpencerLab discuss how this could contribute to human lymphoid tissue content & function hubs.la/Q02JSNWX0
Michael Pitcher retweeted
Our latest perspective piece is out now in @JExpMed! Here we propose that recruitment of immature B cells could contribute to human lymphoid tissue structure and function.
rupress.org/jem/article/221/…
Michael Pitcher retweeted
Lots of amazing work on display at Spatial Biology Research @ King’s symposium, a pleasure for our postdoc @michaeljpitcher to showcase our work with the Spatial Biology Facility, using @nanostringtech CosMX to study B cells in gut lymphoid tissue
@KCLcancer_pharm @JelmarQuist
Proud to joint-author with Lucia Montorsi on this latest paper from our lab, using spatial transcriptomics, imaging mass cytometry and more to investigate feature of autoimmunity present as interacting features of healthy gut
Our latest paper is out now in @NatureComms!
Lucia Montorsi and @michaeljpitcher from our lab and collaborators identified characteristics of autoimmune diseases as normal components of the immune system in human gut:
nature.com/articles/s41467-0…
New review of GALT and B cells from our lab and @BemarkMats is out now in @TrendsImmuno !
Our review of the current knowledge of GALT is out now in @TrendsImmuno ! In collab with @BemarkMats, we discuss GALT organisation, B/T cell interactions, responses to microbiota, and links between GALT and autoimmunity doi.org/10.1016/j.it.2024.01…
Michael Pitcher retweeted
Our review for Trends on the current knowledge of GALT is now out. We discuss its organisation, the role of GALT in B cell development, its role in autoimmunity and T cell help to B cells. Thanks to @JoSpencerLab and @michaeljpitcher for the collaboration. doi.org/10.1016/j.it.2024.01…
Michael Pitcher retweeted
Gut-associated lymphoid tissue: a microbiota-driven hub of B cell immunity dlvr.it/T39fjH #immunology
New preprint from our lab out now!
Our new preprint is live on bioRxiv! We identify a link between microbiota, intestinal immunity and autoimmunity using protocols that include a new method to resolve spatial transcriptomics to single cells
biorxiv.org/cgi/content/shor…
Michael Pitcher retweeted
Our letter, "Heritable diversity in the human antigen inexperienced B cell repertoire", is out now in Molecular Immunology! We show TS & naïve B cells have more similar gene expression if they are from the same clone @michaeljpitcher
authors.elsevier.com/c/1hF1Q…
Michael Pitcher retweeted
Massive congratulations to Bekki Velounias, who successfully defended her PhD thesis today!
Michael Pitcher retweeted
Happy that a review written together with @JoSpencerLab human on gut inflammation and B cells is now out in @NatRevGastroHep. In it we discuss induction of gut responses, tissue sampling problems, and changes during IBD, coeliac disease and autoimmunity. nature.com/articles/s41575-0…
Michael Pitcher retweeted
Open access to our latest paper is available through our group page:
kcl.ac.uk/research/spencer-g…
Click the link under "Human B cells in tissues" in the Projects section
Thrilled to announce publication, led by @JQ_Siu, is now out in @SciImmunology. We describe dividing transitional & naïve B cells and also marginal zone B cell heterogeneity, with implications for lupus. science.org/doi/10.1126/scii…
Michael Pitcher retweeted
🔬Newly published in @SciImmunology, by @JoSpencerLab's @JQ_Siu, @michaeljpitcher, @Thomas_J_Tull & others:
Deep analysis reveals new insights into B cells and the role they play in disease. Find out more ⤵️
kcl.ac.uk/news/researchers-f…
Latest paper from our lab @JoSpencerLab is out now in @SciImmunology! Pleased to have contributed to this work by fantastic @JQ_Siu and collaborators
Super excited to share that our work about human marginal zone B cell heterogeneity in lymphoid tissues and its implications in lupus is now published in @SciImmunology. Huge thanks to @Gates_Cambridge and @CCSF67 for their support. science.org/doi/10.1126/scii…
Pleased to played a small part in this, the latest paper from our lab:
Our latest paper, led by @SilviaTrevelin and in collaboration with @stuartjdneil, is out now in @FrontImmunol! We show disruption of ileal Peyer's patches in severe COVID-19 including depletion of germinal centres, independent of local virus levels. frontiersin.org/articles/10.…
Michael Pitcher retweeted
Our collaboration with @fcicca is out now in @NatureComms! Led by Michele Bortolomeazzi, it presents SIMPLI: an end-to-end software tool for analysing multiplexed imaging data (such as imaging mass cytometry) that unifies all steps of the process nature.com/articles/s41467-0…