@mohebial

Dopamine. Science. Technology. Reason. Photography. Baking. Films. Psych Prof @UWpsych

 Madison, WI
mohebial.com
Joined August 2010
  • Tweets4K
  • Following1K
  • Followers1.9K
392Media
Ali Mohebi retweeted
mbruchas@mbruchas11 Jan 2025
Pls chk out the Bruchas lab's new preprint "Endocannabinoids facilitate transitory reward engagement through retrograde gain-control". Congrats @DavidJMarcus2 @cloverpharm @StellaLab11 @Graphtablet & many other colleagues. biorxiv.org/content/10.1101/…

Endocannabinoids facilitate transitory reward engagement through retrograde gain-control

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory...

biorxiv.org
David Marcus@DavidJMarcus210 Jan 2025
I’m excited to share the most recent study from the @mbruchas lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system! biorxiv.org/content/10.1101/…

Endocannabinoids facilitate transitory reward engagement through retrograde gain-control

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory...

biorxiv.org
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(1/7) Far-red dopamine sensor is coming! Excited to introduce our chemigenetic DA sensor, HaloDA1.0! #Dopamine #FarRedSensors, #GRAB biorxiv.org/content/10.1101/…

In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors

Neurochemical signals like dopamine (DA) play a crucial role in a variety of brain functions through intricate interactions with other neuromodulators and intracellular signaling pathways. However,...

biorxiv.org
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Excited to share work from Twitter less Juan Enriquez-Traba, grad student from the lab. Juan and the team demonstrate that dopamine regulates differential aspects of reward, motivation vs reinforcement, via co-expressed D3 and D1 receptors nature.com/articles/s41593-0…
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My paper is out!! 🎉 "Opponent control of reinforcement by striatal dopamine and serotonin", @Nature Here, we show that dopamine and serotonin signals form a gas-brake system for reward in the mammalian brain 🧠 THREAD ⬇️ 1/n
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The first piece of work from my PhD has now been uploaded to biorXiv! Short 🧵below:
bioRxiv Neuroscience@biorxiv_neursci12 Nov 2024
Hunger modulates exploration through suppression of dopamine signaling in the tail of striatum biorxiv.org/cgi/content/shor… #biorxiv_neursci
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New paper from @avmah44 and @golden_neurons: “Dopamine transients encode RPEs independent of learning rates.” Rats’ dynamic learning rates approximate Bayesian changepoint detection. DA does not reflect dynamic learning rates. sciencedirect.com/science/ar…
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🚨 🚨 PSA for #SfN2024 Dopaminers Sad I won’t be there to join you! Pls RT
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The neuroscience field is grappling with whether to modify the long-standing theory of reward prediction error—or abandon it entirely. By @avaskham thetransmitter.org/dopamine/…

Reconstructing dopamine’s link to reward

The field is grappling with whether to modify the long-standing theory of reward prediction error—or abandon it entirely.

thetransmitter.org
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I’m looking for a research technician to help study the role of the basal ganglia in foraging decisions @Neuroscience_NU. This is a great opportunity to get experience before grad school and help lead a project!
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Finally in our review of @ANDPDProject1 #research we highlight from @RaffaellaTonini, @MoratallasLab, @FisoneL and @SilberbergGilad : pubmed.ncbi.nlm.nih.gov/3894… Insights on brain areas and Parkinson's All our results on #anxiety and #Parkinsons are here: and-pd.com/and-pd-results
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New preprint from the lab! 🚨 Replay of procedural experience occurs in the striatum and is independent of the hippocampus. Heroic effort by @EmmettJThompson & the rest of the team @_JasvinKaur, @_GeorginaMills, @dorrell_will, @ClementineDomi6, @TomNotGeorge 🧵👇1/13
bioRxiv Neuroscience@biorxiv_neursci7 Jun 2024
Replay of procedural experience is independent of the hippocampus biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Exciting news from our lab at Duke University! We've used DART to block dopamine pauses mediated by GABAA receptors. This simple experiment led to three unexpected outcomes. See more in our full paper: tinyurl.com/5x99phdd @DukeUBME @DukeBrain @ASAP_Research #ASAP_CRN
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Replying to @mohebial
Not twitterless anymore, just fell into the trap
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Latest pre-print! Here we show that in the NAcc the relationship between cholinergic and dopaminergic signals changes depending on task states. This is relevant to several current discussions, including the role of dopamine ramps and how dopamine signals RPEs vs other variables
bioRxiv Neuroscience@biorxiv_neursci4 May 2024
Dopamine and acetylcholine correlations in the nucleus accumbens depend on behavioral task states biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Super proud of this tour de force preprint by @heejaesayshi. Acetylcholine demixes heterogeneous dopamine signals for learning and moving. biorxiv.org/content/10.1101/…

Acetylcholine demixes heterogeneous dopamine signals for learning and moving

Midbrain dopamine neurons promote reinforcement learning and movement vigor. A major outstanding question is how dopamine-recipient neurons in the striatum parse these heterogeneous signals. Here we...

biorxiv.org
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Do you think about dopamine ramps? If so, we hope that this story would be interesting to you and demonstrate that an underappreciated experimental variable has a strong influence on when they appear in a task. Work led by Joey Floeder and helped by @HuijeongJeong @mohebial
bioRxiv Neuroscience@biorxiv_neursci30 Mar 2024
Mesolimbic dopamine ramps reflect environmental timescales biorxiv.org/cgi/content/shor… #biorxiv_neursci
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New Dynamic Memory Lab Podcast! Scientifically backed protocol to optimize episodic memory through effects pedals. Forget supplements, use effects to enhance theta oscillations, jack up your dopamine, and leverage motor system plasticity. No talent? No problem! @EHX
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Happy to share new preprint from the lab, together with William Scott Thompson and Sten Grillner @karolinskainst , any comments welcome!
bioRxiv Neuroscience@biorxiv_neursci20 Mar 2024
Motor cortex directly excites the output nucleus of the basal ganglia, the substantia nigra pars reticulata. biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Come join the Cognitive Origins Lab at UW-Madison! We are hiring two full time lab managers to start this summer! One specializing in child development and one in non-human primate cognition. Application links below. Application Deadline April 10, 2024
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Excited to share our methods work out in #Neurophotonics today! We coupled a new microprism design with a long working distance objective to track thousands of cells across days in the striatum. doi.org/10.1117/1.NPh.11.3.0…
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