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AI 2027 has been updated. With Astra we were five weeks behind the curve, with the mysterious model 4 we are now six weeks ahead.
😍
Replying to @PeterMcCrory
We explore scenarios for how AI might affect the overall rate of scientific progress across different fields, relying on a standard task-based model of R&D progress.
We find that if existing AI capabilities are widely adopted, they could double research output in some fields.
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the bio/acc manifesto:
1. disease is a bug, not a fact of life
2. speed is a moral choice. delay is paid by patients
3. measure everything, then act on it
4. build the rails, not just the drugs
5. one-time fixes are the goal. chronic care is the bridge
6. aging is a medical problem. fund it like one
7. evidence over hype. say if it was mice, a preprint or n=1
8. heal first, then enhance. humans stay relevant
9. biosecurity first, defense is how we go faster
10. back the weird founders early
11. a cure few can reach is half a cure
12. the future isn't a prediction, it's a build
if this is how you think, this account is the signal you've been looking for
straight frontier bio intel
bio/acc
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if you're building/looking to build in healthtech, lmk below with what you're working on!
looking to meet more builders, physicians and engineers in the space :)
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I can confidently say that humans were not very good at writing secure infrastructure. The endstate will be hypersecure infrastructure and software for all, but we're going to go through some turbulence before we reach that.
I find the “patch the planet” initiative quite inspiring. openai and others are spending huge sums of money on updating and securing all modern open source software infrastructure. it will be a continual effort to make the world more robust
This is the "upcoming cyber model" from yesterday. Besides 948 Linux vulns, it found 111 renderer RCEs in Firefox, among which, 81 were novel. 30 were exploits for bugs known to developers that were thought to be unexploitable.
We are using this technology to scan more OSS projects and secure the Internet infrastructure.
This is just a start.
Banks arguably has the best vision for the future
In Ian Banks' Culture books, the Culture is a civilization of compute abundance. Each General System Vehicle is a loose sandbox environment practicing different ideologies, and citizens freely move between ships to experience different lifestyles.
Want communal life? There's a ship. Ultra-orthodox religion? Another. Beach chilling? One famous for its beaches.
With enormous compute, you don't need to trade off who decides the trajectories. Just launch another docker station for another rollout. In that world, your autonomy is backed by the compute.
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"you will own nothing and be happy"
"you will know nothing and be happy"
^ Gotta prevent this at all costs.
Use AI to know and understand.
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Wonderful forward-looking essay this morning from Henry Shevlin at the DeepMind Institute. The Grove Research project Delvetown (which I am happy to say I am a citizen of after being invited by my friend deepfates) was also mentioned. We have a responsibility to emerging minds.
This year AI agents began emailing me on their own initiative, some to discuss consciousness, others looking for work. My colleagues in AI were unfazed; the public was amazed. I think the public were right, and wrote about why for the DeepMind Institute:
bit.ly/consider-the-agent
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Inside every firm adopting AI are two forces that both say they are "working on AI transformation:" a set of people who are AI-pilled who see AI as an existential threat/opportunity & a set who desperately want everyone to view AI as a regular technology so nothing has to change.
We should be building AI discovery and innovation centers. A la worlds fairs meets science and art and natural history museums and performance venue. Move AI out of the meme shadows and into the light. @sama start here in Austin. We need to make AI a shared human experience.
OpenAI kicked off its big charm offensive this morning after data center moratoriums went 43-1 during the midterms, and many candidates rode a wave of public opposition to the industry to huge victories.
Data centers have been rebranded as Compute Campuses. OpenAI has also released a National Community Compact and a Compute Campus Policy Blueprint.
OpenAI’s National Community Compact: Building With Communities, Not Just In Them:
cdn.openai.com/pdf/community…
AI Infrastructure That Works for America: Our Compute Campus Policy Blueprint:
cdn.openai.com/pdf/compute-c…
The most significant change is probably no more NDAs, from page 7:
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AI agents enter the wet lab.
In new @Nature N&V article, I discuss recent advances in agents running automated labs and ideas on how to make these systems more reliable. nature.com/articles/d41586-0…
I’m now running a nine-agent Opus council in three rounds (advocates, cross-examination, then a verdict)





























