flourish: love, learn, play
Austin, TX
Joined June 2015
- Tweets4.4K
- Following6.6K
- Followers979
- Likes61.1K
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AI 2027 has been updated. With Astra we were five weeks behind the curve, with the mysterious model 4 we are now six weeks ahead.
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the bio/acc manifesto:
1. disease is a bug, not a fact of life
2. speed is a moral choice. delay is paid by patients
3. measure everything, then act on it
4. build the rails, not just the drugs
5. one-time fixes are the goal. chronic care is the bridge
6. aging is a medical problem. fund it like one
7. evidence over hype. say if it was mice, a preprint or n=1
8. heal first, then enhance. humans stay relevant
9. biosecurity first, defense is how we go faster
10. back the weird founders early
11. a cure few can reach is half a cure
12. the future isn't a prediction, it's a build
if this is how you think, this account is the signal you've been looking for
straight frontier bio intel
bio/acc
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if you're building/looking to build in healthtech, lmk below with what you're working on!
looking to meet more builders, physicians and engineers in the space :)
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I find the “patch the planet” initiative quite inspiring. openai and others are spending huge sums of money on updating and securing all modern open source software infrastructure. it will be a continual effort to make the world more robust
This is the "upcoming cyber model" from yesterday. Besides 948 Linux vulns, it found 111 renderer RCEs in Firefox, among which, 81 were novel. 30 were exploits for bugs known to developers that were thought to be unexploitable.
We are using this technology to scan more OSS projects and secure the Internet infrastructure.
This is just a start.
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Banks arguably has the best vision for the future
In Ian Banks' Culture books, the Culture is a civilization of compute abundance. Each General System Vehicle is a loose sandbox environment practicing different ideologies, and citizens freely move between ships to experience different lifestyles.
Want communal life? There's a ship. Ultra-orthodox religion? Another. Beach chilling? One famous for its beaches.
With enormous compute, you don't need to trade off who decides the trajectories. Just launch another docker station for another rollout. In that world, your autonomy is backed by the compute.
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"you will own nothing and be happy"
"you will know nothing and be happy"
^ Gotta prevent this at all costs.
Use AI to know and understand.
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Wonderful forward-looking essay this morning from Henry Shevlin at the DeepMind Institute. The Grove Research project Delvetown (which I am happy to say I am a citizen of after being invited by my friend deepfates) was also mentioned. We have a responsibility to emerging minds.
This year AI agents began emailing me on their own initiative, some to discuss consciousness, others looking for work. My colleagues in AI were unfazed; the public was amazed. I think the public were right, and wrote about why for the DeepMind Institute:
bit.ly/consider-the-agent
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Inside every firm adopting AI are two forces that both say they are "working on AI transformation:" a set of people who are AI-pilled who see AI as an existential threat/opportunity & a set who desperately want everyone to view AI as a regular technology so nothing has to change.
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Read the full preprint here: www-cdn.anthropic.com/76e55f…
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AI agents enter the wet lab.
In new @Nature N&V article, I discuss recent advances in agents running automated labs and ideas on how to make these systems more reliable. nature.com/articles/d41586-0…
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In the long run, put optimization pressure on AI for unbounded opportunities, e.g., science and tech (which build upon prior art) rather than accounting (bounded once an AI successfully follows all tax laws and regulations).
.@dylan522p explains his position that the first trillion dollars of AI spend won't be used to replace white-collar work:
"Replacing white-collar work is something that will happen, but that's not going to drive the first trillion dollars of AI spend. Those are not industries that are going to diffuse AI capabilities quickly. It's going to take them quite some time to reorder how their OpEx is spent. Because companies have a lot of inertia with regard to people's jobs, changing how their compensation works, how many people work on what, etc."
"There are areas where we think that intelligence is very, very important, though. These include areas like chip design, cybersecurity, financial services, life sciences, materials science, software engineering. You can absorb unlimited intelligence [in these areas]. And there are two reasons for that."
"One is that it's a domain where humans aren't anywhere close to the frontier and there's just so much to discover. Think materials science, chip design, anything in the scientific realm. We figure out new stuff, we deploy it, we make everyone's lives better."
"And there's the other world which is adversarial. Specifically, finance and cybersecurity. It's human vs. human, and we're constantly going to be leveling up, either trying to arb each other like quants do, or trying to hack each other and then play defense. So there's this constant demand for intelligence because when you have more intelligence than the other parties in the market, you win."
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Medicine is a compute problem.
This model was able to predict your next health event.
Trained on 300M patients and 16B health encounters.
We overestimate the mystery of our bodies and are more predictable than we want to believe.
Cool seeing that illusion chipped away.
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I rarely agree with Scott Alexander's doomerism these days, but he's spot-on here.
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This is an incredible accomplishment by India. Absolutely world-changing.
India saw about 496 million people lifted out of poverty between 2011 and 2023 in one of the world’s fastest declines in this metric, the World Bank said, although the gains remain uneven. bloomberg.com/news/articles/…
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Lilly won't call it a psychedelic, but there it is: intranasal 5-MeO-DMT, sitting in $LLY's neuroscience pipeline. Still surreal.
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🫀 Can coronary atherosclerosis actually regress?
Our new randomized FLOWPROMOTE trial analysis, published TODAY in JAMA Cardiology, shows remarkable coronary plaque regression with intensive LDL-C lowering!
Atherosclerosis is not necessarily a one-way process.
📄 JAMA Cardiology:
doi.org/10.1001/jamacardio.2…
#Atherosclerosis #LDL #Cardiology #CCTA
