Steve Mount (@ongenetics) profile picture

Steve Mount

@ongenetics

Steve Mount, Univ. of Maryland. Interested in gene structure and function, especially pre-mRNA splicing.

 College Park, Maryland
cbmg.umd.edu/people/tenure/stephenmount/
Joined May 2009
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Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)Photo by Steve Mount (@ongenetics)
RFK Jr. is apparently going to tell Congress today that HHS doesn't need much money. The cuts have damaged important science. If he says it's all waste and duplication he's either lying or doesn't know his job. @RepArrington @RepBrecheen @michaelcburgess @RepBuddyCarter
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I loved the TAGC (The Allied Genetics Conferences). This is really too bad. @GeneticsGSA
Image from Steve Mount (@ongenetics)
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RNAseq is commonly performed. We compared N=30 wild-type Bl6 mice to an N=30 heterozygotic knockout with a phenotype, and then downsized. We found you need at least an N= 8-12 to avoid a >50% false positive rate. A 2nd line confirmed the finding. biorxiv.org/content/10.1101/…
Optimizing murine sample sizes for RNA-seq studies revealed from large-scale comparative analysis

Optimizing murine sample sizes for RNA-seq studies revealed from large-scale comparative analysis

Determining the appropriate sample size (N) for comparative biological experiments is critical for obtaining reliable results. In order to determine the N, the usual approach is to perform a power...

biorxiv.org
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Fitbit users are unanimously opposed to removing the browser interface. Many of us feel strongly about it. community.fitbit.com/t5/Fitb… The claim that data and features of the dashboard are available in the app is a lie. Why did they do this? It makes no sense. #Fitbit is failing.
Image from Intermittent Fasting (@IFdiet)
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Rosaceae (berries, stone fruits, apples, and more) has amazing diversity in fruit development. @BerryLab_UMD has vast omics data that captures much of this variation. Now, Muzi Li has put it on a nice database. rosaceaefruits.com/ academic.oup.com/hr/article-… Glad to have helped.
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Want to understand how splicing decisions are actually made in the cell based on pre-mRNA sequence? PhD student Kayla McCue has been hard at work modelling just that, & we're very excited to announce that now you can read about it in her new preprint! biorxiv.org/content/10.1101/…
An Interpretable Model of pre-mRNA Splicing for Animal and Plant Genes

An Interpretable Model of pre-mRNA Splicing for Animal and Plant Genes

Pre-mRNA splicing is a fundamental step in gene expression, conserved across eukaryotes, in which the spliceosome recognizes motifs at the 3’ and 5’ splice sites (SS), excises introns and ligates...

biorxiv.org
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You and @DrJennyLord did a great job putting this together!
Diana Baralle (@ProfDBaralle) profile pictureDiana Baralle@ProfDBaralle4 Jan 2024
Predicting the impact of rare variants on RNA splicing in CAGI6. New paper from us ⁦@CAGInews⁩ #CAGI6 thank you ⁦@DrJennyLord⁩ ⁦@Carolinaj215⁩ ⁦@HtooW⁩ ⁦@ongenetics⁩ ⁦@pedjagogue⁩ link.springer.com/article/10…
Predicting the impact of rare variants on RNA splicing in CAGI6

Predicting the impact of rare variants on RNA splicing in CAGI6

Human Genetics - Variants which disrupt splicing are a frequent cause of rare disease that have been under-ascertained clinically. Accurate and efficient methods to predict a variant’s impact...

link.springer.com
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Predicting the impact of rare variants on RNA splicing in CAGI6. New paper from us ⁦@CAGInews⁩ #CAGI6 thank you ⁦@DrJennyLord⁩ ⁦@Carolinaj215⁩ ⁦@HtooW⁩ ⁦@ongenetics⁩ ⁦@pedjagogue⁩ link.springer.com/article/10…
Predicting the impact of rare variants on RNA splicing in CAGI6

Predicting the impact of rare variants on RNA splicing in CAGI6

Human Genetics - Variants which disrupt splicing are a frequent cause of rare disease that have been under-ascertained clinically. Accurate and efficient methods to predict a variant’s impact...

link.springer.com
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Splicing variation shapes mammalian complex traits. "more sVariants were called than eVariants, and ... multi-tissue sVariants alone explained a similarly large proportion (66%) of heritability to eVariants and sVariants jointly (69.2%)." Also - many trans sVariants!
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OBITUARY Michael Ashburner (1942–2023) cell.com/current-biology/ful…
Image from Alejandro Montenegro (@aemonten)
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I'm starting as one of 23 Associate editors in this new section.
Frontiers - Bioinformatics and Systems Biology (@FrontBioinf) profile pictureFrontiers - Bioinformatics and Systems Biology@FrontBioinf29 Jun 2023
It's our pleasure to announce a new section, #RNA Bioinformatics, in Frontiers in Bioinformatics, led by Prof. Shuhui Song of the Beijing Institute of Genomics, Chinese Academy of Sciences. This section is now open for submissions Discover more: fro.ntiers.in/RNA_Bioinforma…
Image from Frontiers - Bioinformatics and Systems Biology (@FrontBioinf)
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Join ISMB/ECCB 2023 in Lyon, France, or virtually July 23-27! I'm not going to make it this year, but ISMB is always a great conference. Let's shape the future of our field together! invt.io/1txbkeu1w6y #ISMBECCB2023 #ComputationalBiology #Bioinformatics #Conference
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This is a nice story about genetic analysis leading to a cure. STAT4 variants contribute to disabling pansclerotic morphea, and it looks like JAK inhibitors are a potential treatment. I've been hearing about it from @brynjmatt for a while now. genome.gov/news/news-release…
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Another very original insight from @Mayr_Christine! "a novel mode of protein activity regulation"
Christine Mayr (@Mayr_Christine) profile pictureChristine Mayr@Mayr_Christine19 Feb 2023
New preprint from us! mRNAs act as chaperones for IDRs. mRNAs often bind to IDRs. This changes their conformational ensembles to drive protein complex assembly, and controls protein activity. Thank you @VickyLuo0223! biorxiv.org/content/10.1101/…
mRNA interactions with disordered regions control protein activity

mRNA interactions with disordered regions control protein activity

The cytoplasm is compartmentalized into different translation environments. mRNAs use their 3′UTRs to localize to distinct cytoplasmic compartments, including TIS granules (TGs). Many transcription...

biorxiv.org
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I'm looking at Post.news. You can also sign up for Post. post.news/?r=U8tZ4
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Grateful to @NIDDKgov @IRPatNIH for granting me tenure at #NIH! Special thanks to current and former members of the lab for their essential contributions, Susan Buchanan and Mike Krause for their guidance and mentoring, our generous collaborators and colleagues in #RNA #tRNA.
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What I want to know is who redefined "junk DNA" to include regulatory sequences. Conserved regulatory sequences are not junk DNA. beta.nsf.gov/news/butterfly-…
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I just completed a survey on @GeneticsGSA journals. If you're a geneticist, you can too. #GSASurvey22 e.genetics-gsa.org/Prod/link…
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Steve Mount retweeted
jean beggs (@JeanBeggs1) profile picture
jean beggs@JeanBeggs118 Aug 2022
Excited to be going to the celebration of Joan Steitz - 50 years at Yale. What a star! @rna @yale
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nature.com/articles/d41586-0… This is a nice, simple, schematic of the major phylogenetic events of SarsCoV2
Image from Steve Mount (@ongenetics)
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