human | partial to curiosity & natural light | believes in magic

San Francisco, CA
Joined March 2011
small businesses want all-in-one large businesses want best-in-class
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everything is a sales funnel message sells the open/listen (attention) open sells the meeting (time) meeting sells the 2nd meeting (pitch) 2nd meeting sells the offer (sale) start with the first step, not the last true in dating, recruiting, fundraising, job hunting, etc.
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quite clear that "paperwork" is going the same way as "hanging up the phone" our grandkids will have no idea what it means
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an underdiscussed toxicity of social media is pervasive sycophancy
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the final skill is consistently turning a "no" into a "yes"
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Oct 2021 🤝 Oct 2026
rough math on Anthropic 26e $86bn exit ARR $53bn rev -$25bn op income 27e $138bn exit ARR $112bn rev -$60bn op income something's gotta give
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when anyone asks why I moved to Bay Area from MA
Imagine having 350+ days of comfortable weather every year.
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Patrick Despres-Gallagher retweeted
Confidence is demonstrated ability.
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you know the title "founder" is now meaningless because cos are giving out "founding" titles at companies with $1B in run rate
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proud to be small investor in and supporter of @ayanb and @WithAmpersand extremely challenging technical problem with tier 1 team that will deliver real automation across enterprises globally
Your AI is vaporware without deep integrations with your customers’ systems of record. Introducing @WithAmpersand: integration infrastructure for enterprise agents. We power 11x, Orb, and Square's ability to take agentic action in systems of record like Salesforce, SAP, NetSuite, and Workday. Ask anyone serious about building AI and they’ll tell you: - The SaaSpocalypse didn’t happen. The world depends on CRMs, ERPs, HRISs, and ITSMs. - Your customers customized their deployments beyond recognition. - Systems of record companies are basically monopolies. They never had to make their APIs and MCPs user-friendly. - Docs don't explain half the weird edge cases you'll hit. - One bad write can blow up your pilot or renewal. - Once you finally get it working, someone changes a field and it breaks again. The world's data lives in structured databases. AI needs a translation layer to work with it. So, for your AI to truly transform the way enterprises work, you'll need deep integrations built for: - scoped permissions - bi-directional actions - real-time speed for agents - custom objects, fields, and workflows for each of your customers We built Ampersand to power the future of software. AI didn't trivialize writing integrations. It made them the critical path. I believe that deeply, so I didn't make a launch video about Ampersand. Instead, it's the best builders I know explaining just how big of a challenge this is.
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traditional identity and access management systems are now completely broken and business limiting need to rethink from ground up
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you can't compete against this
The @BostonCollege Investment Committee (an LP and my beloved alma mater) asked for a few thoughts on what's happening in AI. I recorded a test run yesterday morning and then shared it with my partners, who encouraged me to share it more broadly... so here you go! This is not a sales pitch, it's just a reflection on what we're seeing. And it wasn't intended to be shared, so please pardon the rough edges. loom.com/share/c016702964a04…
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computational biology is so clearly the frontier now
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always make time for anyone who obsessively dedicates their life to something
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entrepreneurship is never a waste of time, but it certainly can feel like it when each model release destroys the unique value of 100+ startups. the bad news is that you have to start over. the good news is that you are wiser. ride the wave. don't swim against the current.
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the problem with vibecoding is that people mistake building a "productive" system as productivity itself 95% of what gets built never gets used and is simply procrastination
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Patrick Despres-Gallagher retweeted
After months of writing, 'How to Unclench' is finally live! It's an interactive essay packed with stories, science & guided practices to help you unclench. → howtounclench.com
one of the best ways you can experience this is turn on a cold shower, and notice what happens to your body as you’re about to go in, then train yourself to unbrace… and then apply that same move to everything in increasingly subtle ways
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the creative paradox you always create average work w/ many people in mind - definitionally, it sort of resonates with everyone (ergo no one) you sometimes create incredible work for one person (often yourself) who you want to love it - and if you're lucky, other people do too
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most AI products are in race to the bottom (i.e. high volume, low margin) believe we will see some pursue premium models w/ access focused on tier 1 customers who pay $$$$ to compete with scarce & exclusive capabilities, benchmarks, and insights (i.e. high margin, low volume)
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