Way too much counterfeit supplements on Amazon. But you like the pricing... What I prefer about Fullscript is the direct to brand sourcing model - so you know what you are getting. My Fullscript is open to everyone with exclusive discounts... us.fullscript.com/s/reallyop…

We had a lot of peptides that compounding pharmacies could produce in the USA - this isn't a new thing. Pricing was $300+/mo for common peptides like TB-500. I don't see how this new push will be significantly different and drive pricing down. Been there, done that. And even if we can get below $100 - that's still expensive for these products. The grey and black markets will persist. People want to pay $3, not $300. Let's talk when compounding pharmacies start hitting $29...

How hard you move beats how long you move. Good news for biohackers. Nobody is asking you to jog around the block for hours. The hard minutes are short ones. Same total activity. Wildly different outcomes. In 96,408 UK Biobank adults, the people who did just over 4 percent of their movement hard enough to get out of breath had 29 to 61 percent lower risk of eight major diseases and death. For inflammatory diseases, intensity counted *twenty times* more than volume. Your body counts effort, not minutes. It is not permission to move less. It is a multiplier on the movement you already do. In other words, if you can stay active all day, then a little structured sprint work will vastly outperform jogging around the block for hours.

My wife isn't a fan of my interior design. I told her she's wrong. She's wrong, right?

He's right. And his comment wasn't all that deep or controversial within the context of his work. The post was also a bit of an IQ litmus test for those who can't process basic context and instead jump to emotional reactivity.

The present moment is a gift, that's why it's called a present. And you can accept this gift and the joy it brings at any moment you desire.

Dumped Amex Platinum last year. Garbage product. The airport lounges are awful. We hit up a regular airport bar/restaurant or even just an empty gate to chill at. It's infinitely better than the putting your name on a waitlist for access to the Amex homeless shelter.

You can tell which of these two lives in Vegas and who is just visiting...

What gives you pleasure today will give you pain tomorrow. The third drink is all pleasure at midnight. By 7 AM it is all pain. Pleasure and pain come as a pair. Nobody gets to buy just one side. This is why you don't chase pleasure. You'll always pay for it.

Exit the insurance madness and win. Not just patients doing it with alternatives (check my page), but physicians taking back autonomy as well.

Pessimism can kill you. But that's not the full story. Finland followed 2,267 adults for 11 years. The most pessimistic had 2.2 times the risk of dying from coronary heart disease as the least pessimistic. But optimism did nothing. No protective effect at all. Which means that the fix is not forced positivity. It is dropping the expectation that everything will go wrong.

When hungry, we eat. When tired, we sleep. Nobody tries to fight sleep every day. It would be miserable, and you would eventually lose. We tell people to fight hunger every day and call it discipline. Yet willpower always loses to biology.

Not sure we quite understand what "whole foods" is - but it could certainly be worse.

We are already seeing this abundance, though. It's already here. Upload your medical records to your favorite AI and you can already skip expensive doctor visits in many cases. It already reads imaging. You can upload extensive health records and get incredibly useful feedback. For free. This is already happening. More specialized integrations will be expensive at first because they can be, just like a new drug, but it's only a matter of time before they are all fully disrupted.

Trashing optimization is becoming trendy now. Entirely predictable. Anything popular brings out the contrarians. Human nature. Their whole argument is pointing at people who are clearly not optimized and calling that optimization culture. If obsessing over optimization is wrecking your mental health and your life, you are not optimized, by definition. And definitely not really optimized.

These numbers should embarrass the whole medical establishment. Microsoft built a panel of AI agents that argue about your case, order tests one at a time, and settle on a diagnosis. On 304 NEJM cases so hard they get presented at conferences, the panel hit 83%. Human generalists got 36%. ER cases: 80% vs 47%. Half the testing cost. And it lifted weak models the most, which tells you the magic is in the process, not the model. The future of medicine is AI.

"Vacation" is a funny word. We have normalized it so completely that nobody stops to ask what it actually is. A quota of trips per year, dosed out like a vitamin you are deficient in. For what? Why? Who decided that going somewhere is a requirement of life? And to be clear, rest is not the issue. Time off is not the issue. I am talking about the vacation itself. The production.

You can apply this to almost everything that AI is going to disrupt. Engineering, coding, medical, driving, even sales and customer service. The humans are the weak link and always will have been. But our collective hubris make this a difficult reality to accept.

I stopped taking AlphaGPC everyday due to some concerning data that I verified with my own testing. But it doesn't mean we need to entirely avoid it, either. reallyoptimized.substack.com…