ThorstenGnad retweeted
🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n]
nature.com/articles/s41586-0…
ThorstenGnad retweeted
Excited to share our new review in @NatRevDrugDisc covering ongoing efforts to therapeutically target chromatin remodelers focusing on SWI/SNF complexes. Congratulations to authors @HaydenMalone3 and Charlie! @stjudegraduate @stjuderesearch #swisnf (1/9) nature.com/articles/s41573-0…
ThorstenGnad retweeted
It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇
nature.com/articles/s41564-0…
ThorstenGnad retweeted
📢New Open🔓Access Article Alert
The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice by Charles W. Collinge & Alessandro Bartolomucci et al.
rdcu.be/dNpLk
#frailty #SocialFrailtyIndex #biologicalage #socialdeterminantsofhealth #geroscience
#Progeria
🚨Happy to share our latest paper 🎉🥳
"The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice"
@GeroScienceAGE @LammingLab @NIA_BSR
link.springer.com/article/10…
Highlights and SOPs in the thread below.
ThorstenGnad retweeted
A new mode of action of sulfonylureas is proposed which is mediated via their interference with PPARγ phosphorylation rather than via classical PPARγ agonist activity at clinical concentrations @MolMetab sciencedirect.com/science/ar…
ThorstenGnad retweeted
Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here nature.com/articles/s42255-0…
ThorstenGnad retweeted
💫NEW: @labpfeifer, @LaiaSalisa & co show that, in #preadipocytes, #EPAC1 enhances brown #AdiposeTissue growth and the function of #ThermogenicFat in obesogenic conditions. EPAC1 activation induces human brown adipocyte proliferation and differentiation.
nature.com/articles/s41556-0…
ThorstenGnad retweeted
Happy to finally share our work on the role of EPAC1 in brown adipose tissue @NatureCellBio
nature.com/articles/s41556-0… – at Bonn, Germany
ThorstenGnad retweeted
Extremely happy to see the results of a great collaboration out in Science. This work spearheaded by Franziska Heydenreich provides new insights on how the pharmacological properties of GPCR ligands are propagated through receptors. science.org/doi/10.1126/scie…
ThorstenGnad retweeted
Today marks the birthday of two (!) remarkable women scientists🥳- Marie Skłodowska Curie (1867), most famous for the discovery of #radium & #polonium & her #radioactivity research & Lise Meitner (1878), whose brilliance unlocked the secrets of #nuclearfission. Happy birthday, trailblazers!🤗🔬✨#OTD
ThorstenGnad retweeted
Today is the day the Nobel Prize in Physiology or Medicine is announced. Stay tuned! @NobelPrize
nobelprize.org/prizes/about/…
ThorstenGnad retweeted
I'm incredibly thrilled to share the news that our spinout, Embark Biotech, has been acquired by Novo Nordisk! Please find the University of Copenhagen article below as well as the company press release: lnkd.in/eNbPzfYQ
@Metabolcenter @UCPH_Research
Novo Nordisk buys CBMR spinout Embark Biotech, in a deal worth up to €456 million, to acquire their novel approach for treating #obesity and type 2 diabetes! 🚀
“It is a dream come true to have this opportunity to work with Novo Nordisk and strive to transform our discovery into powerful new therapies that could improve the lives of people living with obesity and type 2 diabetes,” says Associate Professor Zach Gerhart-Hines.
At CBMR, Associate Professor Zach Gerhart-Hines, together with his former postdoc, Jakob Bondo Hansen and Professor @Thue_Schwartz discovered that by stimulating a single, previously overlooked receptor with carefully designed, long-acting molecules, it was possible to achieve a similar appetite-suppressing outcome as GLP-1 agonists such as @novonordisk's #Wegovy.
But in addition, these novel molecules also increased the capacity to burn energy and, importantly, directly improved insulin sensitivity.
“I am incredibly proud of being part of this amazing story. A true basic scientific discovery has led to the development of a totally novel therapeutic approach that targets the Holy Grail in diabetes and obesity treatment – energy expenditure and insulin sensitivity. All starting with the establishment of CBMR and the recruitment of Zach and his team 10 years ago,” says Thue W. Schwartz, Scientific Godfather of Embark.
Read the full story on the CBMR website 👇
🔗cbmr.ku.dk/news/2023/novo-no…
ThorstenGnad retweeted
Interested in muscle ageing?
Join us at the Healthy Muscle Aging Conference in Liverpool on September 15th
Registration is open now and you can be in with a chance to win FREE REGISTRATION
Full details: tinyurl.com/3hz6t2ap
#HMAC2023
ThorstenGnad retweeted
A real tour de force on muscle hypertrophy! A big author line of heavy hitters. Well-done! Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions @DrMikeRoberts @kaesser and many more! #myotwitter journals.physiology.org/doi/…
ThorstenGnad retweeted
Presenting my poster - Space, race and place: how racism affects career trajectories of racialised minority PhDs and ECRs at the #LboroDCShowcase!
The poster with the most LIKES WINS! So please get liking and sharing!!
ThorstenGnad retweeted
We revealed a secret sibling to human adipocytes!
SWAT cells are multipotent, secrete extra cellular matrix and share progenitors with adipocytes. Regardless of brown or white fat origin! Joint journey with @soeren1974 in @NatMetabolism nature.com/articles/s42255-0…
4) and who knows, if your work leads to novel substances/drugs I might in the future review your preclinical and clinical data ;)
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3) publications. All the best for your future and hopefully many new exciting findings in the #brownfat and #metabolism @TRR_BATenergy field, watching out for your work! For those who wonder, i am not leaving for industry. i will work on regulation and permit of novel #T2D drugs
2) But this part is now over. As even high profile papers and successful grant applications couldnt notch a tenure it was ultimately time to go.
I deeply want to thank all the awesome people i have come across during my time. All the collaborations that many times resulted in
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1) So much contemplating, so many days of weighing pros and cons. But today was my final day @labpfeifer and i am #leavingacademia. as many peers have experienced before it feels kind of wrong. science and academia have been an essential part of my life for 20 years.




























