ThorstenGnad (@scheibendoc) header
ThorstenGnad (@scheibendoc) profile picture

Former academic working on purines in brown fat and skm. now working for germany medicinal agency reviewing novel t2d and cdv drugs in Bonn, Germany

Bonn, Deutschland
Joined December 2018
ThorstenGnad retweeted
🚨 Today in @Nature, we report GEMINI—a genetically encoded intracellular memory device that writes cellular dynamics into tree-ring-like fluorescent patterns within cytoplasmic protein assemblies.[1/n] nature.com/articles/s41586-0…
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It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s41564-0…
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📢New Open🔓Access Article Alert The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice by Charles W. Collinge & Alessandro Bartolomucci et al. rdcu.be/dNpLk #frailty #SocialFrailtyIndex #biologicalage #socialdeterminantsofhealth #geroscience #Progeria
🚨Happy to share our latest paper 🎉🥳 "The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice" @GeroScienceAGE @LammingLab @NIA_BSR link.springer.com/article/10… Highlights and SOPs in the thread below.
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A new mode of action of sulfonylureas is proposed which is mediated via their interference with PPARγ phosphorylation rather than via classical PPARγ agonist activity at clinical concentrations @MolMetab sciencedirect.com/science/ar…
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Thrilled that our huge team effort with @Kornfeld_JanW is out in @NatMetabolism 🥳 supported by @TRR_BATenergy A huge thank you to all collaborators! If you want to know how a truncated AC3 isoform regulates #BAT function, have a look here nature.com/articles/s42255-0…
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Extremely happy to see the results of a great collaboration out in Science. This work spearheaded by Franziska Heydenreich provides new insights on how the pharmacological properties of GPCR ligands are propagated through receptors. science.org/doi/10.1126/scie…
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Today marks the birthday of two (!) remarkable women scientists🥳- Marie Skłodowska Curie (1867), most famous for the discovery of #radium & #polonium & her #radioactivity research & Lise Meitner (1878), whose brilliance unlocked the secrets of #nuclearfission. Happy birthday, trailblazers!🤗🔬✨#OTD
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Today is the day the Nobel Prize in Physiology or Medicine is announced. Stay tuned! ⁦@NobelPrize⁩ nobelprize.org/prizes/about/…
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I'm incredibly thrilled to share the news that our spinout, Embark Biotech, has been acquired by Novo Nordisk! Please find the University of Copenhagen article below as well as the company press release: lnkd.in/eNbPzfYQ @Metabolcenter @UCPH_Research
Novo Nordisk buys CBMR spinout Embark Biotech, in a deal worth up to €456 million, to acquire their novel approach for treating #obesity and type 2 diabetes! 🚀 “It is a dream come true to have this opportunity to work with Novo Nordisk and strive to transform our discovery into powerful new therapies that could improve the lives of people living with obesity and type 2 diabetes,” says Associate Professor Zach Gerhart-Hines. At CBMR, Associate Professor Zach Gerhart-Hines, together with his former postdoc, Jakob Bondo Hansen and Professor @Thue_Schwartz discovered that by stimulating a single, previously overlooked receptor with carefully designed, long-acting molecules, it was possible to achieve a similar appetite-suppressing outcome as GLP-1 agonists such as @novonordisk's #Wegovy. But in addition, these novel molecules also increased the capacity to burn energy and, importantly, directly improved insulin sensitivity. “I am incredibly proud of being part of this amazing story. A true basic scientific discovery has led to the development of a totally novel therapeutic approach that targets the Holy Grail in diabetes and obesity treatment – energy expenditure and insulin sensitivity. All starting with the establishment of CBMR and the recruitment of Zach and his team 10 years ago,” says Thue W. Schwartz, Scientific Godfather of Embark. Read the full story on the CBMR website 👇 🔗cbmr.ku.dk/news/2023/novo-no…
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ThorstenGnad retweeted
Interested in muscle ageing? Join us at the Healthy Muscle Aging Conference in Liverpool on September 15th Registration is open now and you can be in with a chance to win FREE REGISTRATION Full details: tinyurl.com/3hz6t2ap #HMAC2023
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ThorstenGnad retweeted
Presenting my poster - Space, race and place: how racism affects career trajectories of racialised minority PhDs and ECRs at the #LboroDCShowcase! The poster with the most LIKES WINS! So please get liking and sharing!!
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We revealed a secret sibling to human adipocytes! SWAT cells are multipotent, secrete extra cellular matrix and share progenitors with adipocytes. Regardless of brown or white fat origin! Joint journey with @soeren1974 in @NatMetabolism nature.com/articles/s42255-0…
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After 3 days of BAT Science, with great presentations, intense discussions and exciting Elbe cruise at #BATenergy meeting, I would like to thank all speakers and participants to come to Hamburg. It was a lot of fun...big thanks also to the #DFG for their support! #TRR_BATenergy
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ThorstenGnad retweeted
Three great days of #BATenergy 🔥 und viel pils vom fass 🍺 Wish every conference was held in an auditorium like this - Looking forward to 2025! @TRR_BATenergy 🇩🇪 – at Hamburg, Germany
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ThorstenGnad retweeted
It’s a wrap! Spent three days at #BATenergy meeting in beautiful Hamburg. Thank you for organizing inspiring meeting with crazy busy poster session and boat trip 🛥️and thanks to @BAT_Turku for great company! @TRR_BATenergy @RantakariGroup @InFLAMES_Health @BioscienceTurku – at Hamburg, Germany
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Inspiring talk by @PatrickSeale11 about brown fat development at @TRR_BATenergy meeting today! Thanks to all for sharing their awesome science in Hamburg over the last couple of days 🤩 – at Hamburg, Germany
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