Shailesh K. Shahi (@shahibiotech) header
Shailesh K. Shahi (@shahibiotech) profile picture

Shailesh K. Shahi

@shahibiotech

Neuroimmunologist, Gut Microbiome, Obesity and Neuroinflammation, Multiple Sclerosis,T Cells Immunology, # Dad # Nature and Lab lover # Iowa Hawkeye Fan

 University of Iowa, Iowa City, IA, USA
medicine.uiowa.edu/pathology/profile/shailesh-shahi
Joined August 2017
  • Tweets627
  • Following699
  • Followers434
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Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)Photo by Shailesh K. Shahi (@shahibiotech)
Proud moment at the 173-year-old @CornellCollege Convocation Ceremony 🎓✨ Congratulations to my lab members (shahi.lab.uiowa.edu) #JeannieThao and #EddieBanda on graduating today! Wishing both of you continued success and a bright future ahead #Research #MultipleSclerosis
Image from Shailesh K. Shahi (@shahibiotech)
Image from Shailesh K. Shahi (@shahibiotech)
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A recent study from @Ashu_Mangalam's research lab has produced the most comprehensive genetic and metabolic analysis to date of the oral microbiome associated with #multiplesclerosis. #PathTwitter Read more about his study on our website: pathology.medicine.uiowa.edu…
UI study links multiple sclerosis with unique oral microbiome

UI study links multiple sclerosis with unique oral microbiome

With ads everywhere for pro- or pre-biotic foods and supplements, most people are familiar with the gut microbiome—the trillions of bacteria, fungi, and viruses that colonize our digestive tract—and...

pathology.medicine.uiowa.edu
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Shailesh K. Shahi retweeted
Ashutosh Mangalam (@Ashu_Mangalam) profile picture
Ashutosh Mangalam@Ashu_Mangalam24 Nov 2025
Finally updated our labwebsite after 10 years Science evolved fast, website stayed fossilized Now it’s caught up with our work from gut to oral microbiomes, big-data neuroimmunology, & our mission to reduce human suffering. #Microbiome #Neuroimmunology mangalam.lab.uiowa.edu/
Home

Home

Welcome to the Mangalam LabWe believe that restoring balance between the microbiota and the immune system has the power to transform human health. Our work begins with a simple question: what happens...

mangalam.lab.uiowa.edu
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Shailesh K. Shahi retweeted
Dimitry Krementsov (@DKrementsov) profile picture
Dimitry Krementsov@DKrementsov17 Dec 2025
1. Super interesting new pre-print from @rcaspi and team at NIH, showing that Akkermansia promotes autoimmunity by contracting SCFA-producing Firmicutes. biorxiv.org/content/10.64898… A mini thread follows.
Gut microbial interaction networks control autoimmunity to neuroretina

Gut microbial interaction networks control autoimmunity to neuroretina

The gut microbiome influences the development of immune-mediated inflammatory diseases. One such condition is autoimmune uveitis, a sight-threatening ocular inflammation driven by retina-specific T...

biorxiv.org
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Have you ever wondered how the Comparative Pathology Lab, Iowa Neuropathology Resource Lab and Histology Research Lab work together? These labs are integral for the function of various services and projects in our department and throughout @uihealthcare
Graphic that shows how the three labs work together. CPL and INRL are on the top row with HRL underneath them. CPL provides tissue preparation services for downstream histology, where INRL provides brain tissue and neuropathology expertise and handles all CNS requests. Those two labs then feed into the HRL, which handles all non-CNS histology requests.

ALT Graphic that shows how the three labs work together. CPL and INRL are on the top row with HRL underneath them. CPL provides tissue preparation services for downstream histology, where INRL provides brain tissue and neuropathology expertise and handles all CNS requests. Those two labs then feed into the HRL, which handles all non-CNS histology requests.

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A new study from @Ashu_Mangalam provides evidence that oral microbial imbalance is closely linked to immune activation & metabolic disruption in people with relapsing-remitting MS (RRMS), highlighting oral health as an underappreciated contributor to MS pathobiology. #PathTwitter
Image from University of Iowa Pathology (@UIPathology)
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No.1 Diabetic Foot Surgeon: Every 20 Seconds Someone Develops An Amputation - Dr. David Armstrong - @YouTube youtube.com/watch?v=m9D-QTsH…
Image from David G. Armstrong follow @dgarmstrong.bsky.social (@DGArmstrong)
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Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggoner3 Dec 2025
Architecture of the neutrophil compartment @Nature nature.com/articles/s41586-0… @ivanbamartin @AndrsHidalgo16 @lai9uan @danielacerezo @Yale 🇨🇳🇪🇸🇺🇸
Image from Waggoner Lab (@LabWaggoner)
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Great breakfast meeting with our Grand Rounds speaker, Professor Booki Min, a leading immunologist and an inspiring scientist. His seminar on how LAG3 regulates T regulatory cell (Treg) function in autoimmunity and cancer was phenomenal. #ShahiLab #UIowa @BookiMin
Image from Shailesh K. Shahi (@shahibiotech)
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New advanced imaging technology that detects specific molecules in the brain may find signs of MS lesions months earlier, a study shows. buff.ly/YB5RcwG #MultipleSclerosis #MSTreatment #MSResearch #MSNews
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JCI insight (@JCI_insight) profile picture
JCI insight
@JCI_insight11 Jun 2025
Bariatric surgery causes long term changes to our gut microbiome— @maggiesuebohm, @MakowskiLab & team @UTHSC_Cancer now show these changes can improve the body’s immune response to current breast cancer treatments. See more: insight.jci.org/articles/vie…
Image from JCI insight (@JCI_insight)
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Enrollment is now complete in two Phase 3 clinical trials testing vidofludimus calcium in adults with relapsing forms of multiple sclerosis. multiplesclerosisnewstoday.c… #MultipleSclerosis #MSTreatment #MSResearch #MSNews

Phase 3 trials of vidofludimus calcium in relapsing MS fully enrolled

Enrollment is now complete in two Phase 3 clinical trials testing vidofludimus calcium in adults with relapsing forms of multiple sclerosis.

multiplesclerosisnewstoday.com
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Jeff Rathmell (@JeffRathmell) profile picture
Jeff Rathmell@JeffRathmell11 Jun 2025
Great work--congrats to @BlaiseKimmel (now at @OSUCCC_James) and thanks for letting us (@KimrynRathmell and the R^2 lab) participate!
Immunoengineering Lab (@WilsonLabVU) profile pictureImmunoengineering Lab@WilsonLabVU11 Jun 2025
Excited to share our latest publication in @natBME! Big congrats to all co-authors on this highly collaborative effort – especially to first author @BlaiseKimmel for his dedication to this project! Check out the paper (open access) here: nature.com/articles/s41551-0…
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Shailesh K. Shahi retweeted
Kuchroo Lab (@KuchrooLab) profile picture
Kuchroo Lab@KuchrooLab9 Apr 2025
Replying to @KuchrooLab @ButovskyLab
The immune checkpoint TIM-3 is targeted for cancer therapy, & we found that it is also a promising therapeutic target for Alzheimer's disease. Very excited to share this study led by Kimitoshi Kimura, @ayshwaryas @Zhuoran_Yin1 & @AKhalilnezhad @GeneLayInst. Now out @Nature 2/2
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Fascinating Finding From @KuchrooLab. Many Congratulation
Kuchroo Lab (@KuchrooLab) profile pictureKuchroo Lab@KuchrooLab9 Apr 2025
With @ButovskyLab, we show that silencing TIM-3 in brain-resident immune cells prevents neurodegeneration in a mouse model of #Alzheimers disease. Deletion of TIM-3 in microglia enhances phagocytic clearance of toxic amyloid beta. nature.com/articles/s41586-0…
Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Immune checkpoint TIM-3 regulates microglia and Alzheimer’s disease

Nature - The immune-checkpoint molecule TIM-3 regulates microglial homeostasis, and its microglial-specific deletion reduced cognitive impairment in a mouse model of Alzheimer’s disease.

nature.com
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Myeloid derived suppressor cells transferred to the lungs improved survival of mice during Pseudomonas aeruginosa infection suggesting potential prophylactic and therapeutic roles: mucosalimmunology.org/articl…
Image from Mucosal Immunology (@MucosalImmunol)
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While patients who switched to the therapy later saw significant improvements, those who received it as a first-line treatment tended to have even greater benefits. bit.ly/4iyEHBV #MS #MultipleSclerosis #MSResearch #MSNews #MSTreatment
Image from Multiple Sclerosis News Today (@MSNewsToday)
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Ashutosh Mangalam (@Ashu_Mangalam) profile picture
Ashutosh Mangalam@Ashu_Mangalam28 Mar 2025
Great lab outing with our ever-growing MS group! From Karandikar to Karandikar-Mangalam (2015) to Karandikar-Mangalam-Boyden after Alex’s tenure-track promotion—who knows what’s next? Thanks Nitin @PathImmune for fostering this thriving community! #LabFamily #GrowingTogether
Image from Ashutosh Mangalam (@Ashu_Mangalam)
Image from Ashutosh Mangalam (@Ashu_Mangalam)
Image from Ashutosh Mangalam (@Ashu_Mangalam)
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Glimpses of Jan Suraaj Overseas members celebrating Holi around the world
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Waggoner Lab (@LabWaggoner) profile picture
Waggoner Lab@LabWaggoner18 Mar 2025
42-Parameter (40-Color) Spectral Flow Cytometry Panel for Comprehensive Immunophenotyping of Human Peripheral Blood Leukocytes doi.org/10.1002/cyto.a.24927
Image from Waggoner Lab (@LabWaggoner)
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