silvoLab retweeted
Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) nature.com/articles/s41586-0…
silvoLab retweeted
Our study "Individualized VDJ recombination predisposes the available Ig sequence space" is now published in Genome Research 🥳
genome.cshlp.org/content/ear…
Congrats @rlyhighvariance et al.!
1/11 Did you ever wonder whether individuals have the same probability of generating a given antibody sequence? Turns out, they do not – not even twins!
We showed that humans – including monozygotic twins – have unique VDJ recombination rules. biorxiv.org/content/10.1101/…
silvoLab retweeted
1/Excited to share my first author publication where we create split-engineered base editors (seBEs). Here, we place base editors under the control of a small-molecule to regulate the timing of genome editing and decrease off-target effects. To achieve it: nature.com/articles/s41589-0…
Aside from lamenting time and mental resources wasted when I forgot them, I need examples -possibly life-sciences related- to liven up the talk and convince them that choosing the right positive/negative controls is not magic.
Hopefully, one step closer to the clinic…
It was exciting working on it: methylation, fragmentomics, and all.
Thanks @benbfly and all others!
Just a teaser: the correlation of methylation and tumour fraction (healthy controls are the blue bubbles).
biorxiv.org/content/10.1101/…
Excited to announce our new preprint on Nanopore methylation for liquid biopsy. Thanks for producing these amazing sequences Filippo, @silvoLab and @nanopore, and thanks to the analysis team Efrat and @ShariO_51. Excellent team effort. @The__Taybor said to get cracking so we did!
If you enjoy #RNA biology, #RNAediting, and all sort of RNA modifications (#m6A, etc.), join us next week for the Final EPITRAN Conference.
Just a few hours every day, Mon to Wed.
The registration is free and the discussions engaging…
webmagazine.unitn.it/en/even…
silvoLab retweeted
Accepted manuscript strongly suggesting that apparent SARS-CoV-2 reads that appear to be integrated in the human genome, are in fact an artefact of library preparation.
frontiersin.org/articles/10.…
One of the most inspiring, as a person and as a scientist. A huge loss indeed. I will miss him
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silvoLab retweeted
Do you want to explore basic research but also clinical practice? The IRCM's Master's degree in cellular and molecular medicine (MCM) is for you! ircm.qc.ca/en/studies-and-tr…
This is going to be useful!
Thanks!
PAPER OUT!!! 😄💃🏻🕺💃🏻
A systematic CRISPR screen defines mutational mechanisms underpinning signatures caused by replication errors & endogenous DNA damage
@NatureCancer
@xueqing_zou @BillSkarnes @GenomicsEngland
1/ nature.com/articles/s43018-0…
Final days to apply for a PhD in my lab. The science is interesting and the lab is welcoming. Of course you will also need to deal with the whole ugly Firenze thing on the side...
Interested in targeting cancer through RNA editing? We have an opening for a PhD student in the #MSCA #ITN ROPES project. Contact me if interested. Deadline 16/04.
Call and forms are at
bandi.urp.cnr.it/doc-assegni…
(sorry, english part starts at page 15…)
Please spread the word
silvoLab retweeted
There is an important message here for today’s students. Techniques don’t matter. Questions do. Listing a set of techniques is silly because they will all be out of date in 10 years. But questions drive science forward.
This quoted post is unavailable.
don’t joke about that… there goes our plasticware supply…
Suez Canal blocked by huge container ship theguardian.com/world/2021/m…
For a few hours, LA did NOT have the worst traffic in the world.
(Bonus points for whoever named this the EVER GREEN container ship)
By the way, for all #nanopore aficionados, our work on detection of Copy Number Alterations from #liquidbiopsy is out. No amplification, cell-free DNA goes straight to the flow cells (just add adaptors)
[molecular-cancer.biomedcentr…]
special bonus for cell biologists: HEK293 genomic profile.
Note how all CNVs are NOT clonal.
Filippo, the bioinformatician, politely asked how biologists can use these t̶h̶i̶n̶g̶s̶ cells.
A very good point…
molecular-cancer.biomedcentr…
Interested in targeting cancer through RNA editing? We have an opening for a PhD student in the #MSCA #ITN ROPES project. Contact me if interested. Deadline 16/04.
Call and forms are at
bandi.urp.cnr.it/doc-assegni…
(sorry, english part starts at page 15…)
Please spread the word
PhD positions (Early Stage Researchers) available within the H2020-MSCA-ITN project ROPES “ROle of ePitranscriptomics in diseasES”
Multiple locations, Europe
jobrxiv.org/job/department-o…
#ScienceJobs
