PhD student at Stanford Chemical & Systems Biology. Epigenetics/Mammalian Synthetic Biology @BintuLab
Stanford, CA
Joined December 2019
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I'm thrilled to announce that my PhD thesis work from @BintuLab on how the H3.3K36M oncohistone disrupts the establishment of epigenetic memory is now out in the latest issue of @MolecularCell. shorturl.at/X9IZG (1/4)
Joydeb Sinha retweeted
Our new paper on epigenome editing is out!
We mapped which effector domains regulate transcription across genomic, cell type and DNA-binding domain contexts. Then we built new gene repressor and activator tools with improved efficiency & deliverability
nature.com/articles/s41587-0…
A special thanks to all the coauthors: @nickels_jan, @abbythurm, Connor Ludwig, @michaelathinks, @bella_arch, Jun Wan and my incredible advisor @BintuLacra for helping make the story what it is today. I'm also grateful for the collaboration with Dong Fang’s lab @ZJU_China (3/4)
Lastly, I would also like to give a shout out to Nate Hathaway’s lab @UNCPharmacy for writing a beautiful preview article elegantly describing our work. Please check it out here! : shorturl.at/hycOp (4/4)
Joydeb Sinha retweeted
I’m amped to share our new work to decrypt transcriptional repressors, now on bioRxiv: biorxiv.org/content/10.1101/…
We paired deep mutational scans with machine learning to predict and even tune repressor activity. (1/8)
Joydeb Sinha retweeted
Delighted to see our work tiny.cc/icuazz from the Canzio lab @UCSF on how #cohesin-mediated enhancer-promoter interactions shape stochastic #Protocadherin choice profiles out @ScienceMagazine. #epigenetics #chromatin #DNAmethylation #LoopExtrusion #CTCF #3Dgenome. (1/8)
Joydeb Sinha retweeted
Got out of the nucleus! Tested ~30,000 tiles from human RNA-binding proteins, found lots of domains that downregulate RNA&built an inducible synthetic RNA-binding protein for keeping target RNA at constant intermediate levels: biorxiv.org/content/10.1101/… So many follow-up projects!
Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.1101/… (1/9)
Joydeb Sinha retweeted
Do human RNA-binding proteins have modular regulatory domains that downregulate RNA lifetimes? Our preprint @BintuLab studying this question is now out on bioRxiv, where we indeed identify small domains in RBPs that potently induce RNA degradation! biorxiv.org/content/10.1101/… (1/9)
Joydeb Sinha retweeted
We are hiring a lab manager/research assistant! More details and how to apply here: bintulab.com/2024/06/01/hiri…
Joydeb Sinha retweeted
🚨 New paper alert 🚨 I am so happy to share the first paper of my postdoc in @Mizuno_lab . Here we hope to summarize the cellular landscape of neurons thru the lens of #cryoET. Hope you enjoy. authors.elsevier.com/c/1ivnv…
Joydeb Sinha retweeted
It's a double feature on epigenetic memory today! Check another amazing new preprint on single-cell chromatin compaction and memory establishment from wizard postdoc @fjmrt!
New preprint! We studied how single-cell 3D chromatin structure changes under targeted epigenetic perturbations using multiplexed DNA FISH and synthetic biology tools, and found an intriguing relationship between chromatin compaction and epigenetic memory. biorxiv.org/content/10.1101/…
Joydeb Sinha retweeted
We’re excited to announce our new preprint, ‘The H3.3 K36M oncohistone disrupts the establishment of epigenetic memory through loss of DNA methylation,’ expertly led by graduate student @sinha_joydeb! (1/9) biorxiv.org/content/10.1101/…
Joydeb Sinha retweeted
New preprint! We studied how single-cell 3D chromatin structure changes under targeted epigenetic perturbations using multiplexed DNA FISH and synthetic biology tools, and found an intriguing relationship between chromatin compaction and epigenetic memory. biorxiv.org/content/10.1101/…
Joydeb Sinha retweeted
Our latest paper is out today (with @axmukund @JoshTycko and many other talented trainees): High-throughput functional characterization of combinations of transcriptional activators and repressors, at Cell Systems cell.com/cell-systems/fullte…
Joydeb Sinha retweeted
And we're now online at Cell Systems! Check out the updated paper for some new analyses and overview figures that emphasize the impact of understanding transcriptional regulation by viral proteins. sciencedirect.com/science/ar…
Joydeb Sinha retweeted
Have you ever wondered how to confine bi-stable chromatin states effectively? Then please check out the new preprint from @nickels_jan and @KSneppen
biorxiv.org/content/10.1101/…
Joydeb Sinha retweeted
We're proud to announce our latest preprint, "High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells", out now on biorxiv biorxiv.org/content/10.1101/…! [1/7]
High-Throughput Discovery and Characterization of Viral Transcriptional Effectors in Human Cells biorxiv.org/cgi/content/shor… #bioRxiv
Joydeb Sinha retweeted
(1/3) We are excited to share our new paper now out in @PNASNews. pnas.org/doi/10.1073/pnas.22… #circadian #adipogenesis #obesity
