Last night in Malibu, California.

Americans are flying to Shanghai for a lung cancer pill that the FDA approved 15 months ago. Max Doppelt did it for his mother. Her lung cancer had spread to her brain. The drug most likely to help her, sunvozertinib, had been sold in China since 2023 but was unavailable in the US. So he flew over and came home with 26 boxes. Nineteen months later, she is alive and still working. He says at least 30 Americans have made the same trip. In the trial behind the US approval, the pill shrank tumors in 46 out of every 100 patients whose cancer had worsened after chemotherapy. The holdup is business, not medicine. Dizal, the Shanghai company that makes it, had no US sales network, according to US oncologists in May. AstraZeneca licensed the drug in July for $600 million and says US sales will start this quarter. An @FDA approval helps American patients only when a company actually sells the drug here.

What’s stopping you from buying this Detroit home for only $1,999,000?

About 15% of ~40,000 people who developed cancer have pathogenic (disease-causing) genome variants (PVs) when their DNA was sequenced. That's a big proportion of cancer that would set up prevention or very early detection which is completely missed today @AACR @CD_AACR aacrjournals.org/cancerdisco…

This is insane. THREE different Hurricane forecast cones are now simultaneously aiming at the North American continent.

“Fires break out” “Fight between pilots” The BBC, ladies and gentlemen.

AGENT WARS We asked 5 top AI models to design, engineer and 3D print a bridge to with the goal of holding the most possible weight. 🇺🇸 Anthropic: Claude Opus 5.5 (High) 🇨🇳 Kimi: Kimi K3 (High) 🇺🇸 Meta: Muse Spark 1.3 (High) 🇺🇸 OpenAI: GPT 6 Astra (High) 🇺🇸 SpaceXAI: Grok 4.7 (High) Each bridge had specific parameters. It had to span 2 feet, use a maximum 500 grams of filament, and it had to be under 18 hours of printing time. We specified what type of weight and where we would place it on the bridge. The Score: • Claude Opus 5.5 held an estimated 130 lbs! It took 9 hours and 11 minutes to print 17 parts and used 441 grams of filament. • Meta Muse Spark 1.3 held 26.5 lbs. It took 13 hours and 12 minutes to print 49 parts and used 478 grams of filament. • OpenAI GPT-6 Astra held an estimated 17.5 lbs. It took 15 hours and 44 minutes to print 29 parts and used 442 grams of filament. • SpaceXAI Grok 4.7 did not finish. On assembly it could not stand up by itself. It took 12 hours and 22 minutes to print 29 parts and used 460 grams of filament. • Kimi K3 did not finish. It wasn’t engineered correctly so the bridge could not even be assembled. It took 11 hours and 19 minutes to print 35 parts and used 446 grams of filament. That means our champion for this episode is Claude Opus 5.5. Not only did it hold the most weight (by FAR) it also took the least time to print, used the least amount of parts and used the least amount of filament. This was episode 02 of Agent Wars, stay tuned for episode 03.

A Flock of Altruists - Hit The Breaks Except For Me

NEW: Reed Jobs, a prominent biotech investor (and son of another Jobs you may have heard of), calls for a doubling of the NIH budget to $100 billion. Via @statnews statnews.com/2026/09/21/nih-…

In a new collaborative study publish in @ScienceMagazine today, researchers at 23andMe and @DanaFarber used data from more than 3.3 million 23andMe consenting research participants to characterize a rare inherited EGFR variant that significantly elevates lung cancer risk, while also exploring its relationship to smoking, polygenic risk, ancestry and geography. We found that the EGFR T790M genetic variant is carried by about 1 in 15,000 people in the United States, and is associated with a 25-fold increased risk of lung cancer. Among people who never smoked, carriers had a 60 fold higher odds of developing lung cancer than non-carriers. Illustration credit: @oliveruberti Learn more about the study and work here: 23andme.org/blog/articles/eg…

🆕💥🔴Phase III clinical trial evaluated Silevimig, a bispecific anti-rabies monoclonal antibody targeting antigenic sites I and III, as a substitute for human rabies immunoglobulin (HRIG) in post-exposure prophylaxis. Silevimig is safe and effective alternative for passive rabies post-exposure prophylaxis #idxposts academic.oup.com/cid/article…

Chipotle has gone all in on AI. It has an AI CV recruiting tool (“Ava Cado”) which reduces screening time by 75%. Also, an automated avocado-peeling and coring machine (“Autocado”) that reduces time to make batch of guacamole from 50 mins to 25 mins.

The FDA just approved a myostatin inhibitor for a rare muscle wasting disease to prevent muscle loss. Guaranteed this will be approved soon to be taken with GLP-1s. Myostatin inhibitors will be as big as GLP-1s.

A 25-year-old flew to Shanghai with lymphoma that had beaten everything New Zealand threw at it. He paid less than half of Australia's $600,000 quote. On August 18, his cancer was in complete remission. That's not a miracle story. It's a market forming. The wow isn't "China is cheap." It's this: cancer treatment is splitting into two industries. The old one sells protocols — chemo, radiation, off-the-shelf drugs. The new one sells design — a one-patient factory that re-engineers your immune system and ships it back into your vein. China just industrialized the second one. Patients are already buying the plane ticket. I'm a cardiologist. Here's the deep dive — the breakthrough, the business, and the part that should scare you. 🧵

Verified U.S. clinicians can get free GPT-6 Astra (Pro) access today via ChatGPT for Clinicians. Sign up: chatgpt.com/plans/clinicians…