@trefely

Studying metabolic compartmentalization and metabolite signaling to the nucleus @BabrahamInst

 Cambridge, England
Joined March 2015
  • Tweets235
  • Following515
  • Followers989
8Media
📣Only 1 week left to submit an abstract for the UK's leading #immunometabolism event! #UKimmunomet24 will be packed with cutting-edge #research, plenty of networking & 'Bright Sparks' sessions for #ECRs 🌟 Submit your abstract by Friday 15 March 👉bit.ly/3TUBIKl
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Trefely Lab retweeted
FrezzaLab@FrezzaLab7 May 2023
Good morning all! A very Ac-CoA-rich summary of papers in #cancermetabolism and #mitochondrialbiology is out now, don't miss it: biomed.news/bims-camemi/2023… @Bims_BiomedNews “The truth is not always beautiful, nor beautiful words the truth.” ― Lao Tzu
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The Arany lab@AranyLab4 May 2023
Is histone acetylation really a reservoir for 2-carbon units to make acetyl-CoA? We used 13C tracing to show that ... yes, but not that much. Acetylation is dynamic but contributes only a little to cellular AcCoA demand. @WellenLab @mzspectrum @trefely authors.elsevier.com/sd/arti…
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CLOSING TOMORROW: Join the @trefely lab as their new postdoc! The lab is focussed on the links between diet-derived metabolites and epigenetic regulation. Details: ow.ly/iW6250MKK9N #ScienceJobs #Careers #PostDocPosition
Postdoctoral Research Scientist (Epigenetics/Signalling) Starting salary is £33,970 per annum to £36,724 per annum

ALT Postdoctoral Research Scientist (Epigenetics/Signalling) Starting salary is £33,970 per annum to £36,724 per annum

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Happy to share my postdoc article @Nature from the Metallo lab @salkinstitute on the role of serine in the development of diabetes and its complications. It was an enjoyable and truly collaborative project @KnightLabNews @SatchinPanda @AChaix_UofUtah nature.com/articles/s41586-0…
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Rutter Lab
@RutterLab13 Jan 2023
Our latest Review on Metabolites as signaling molecules is now available @NatRevMCB. Co-Written by the incredible Steve Baker (@BakerLabUtah) @UofUPathology @ARUPLabs go.nature.com/3GGLRCk open access:rdcu.be/c3h4g @HHMINEWS @UofUBiochem

Metabolites as signalling molecules

Nature Reviews Molecular Cell Biology - Metabolites are generally viewed as intermediates or products of metabolism. However, many metabolites are also signalling molecules that regulate metabolic...

nature.com
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Super excited to announce that registration for the first in person Metabolic Physiology Meeting #METPHYS2023 is now open! Come join our amazing speakers on beautiful Hilton Head Island May 1-4, 2023 Meeting and registration details can be found below sablesys.com/metphys2023-the…
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Delighted to share a new collaboration between @DPhaz lab and @TVPLab. We show that many common metabolic cell culture models, despite living in 18% oxygen, are hypoxic - with major consequences for phenotypes! @IMS_MRL @TheBHF @The_MRC 🧵 biorxiv.org/content/10.1101/…

Oxygen is a critical regulator of cellular metabolism and function in cell culture

Cell culture, the workhorse of biomedical research, is generally considered to be hyperoxic. However, oxygen consumption by cells is underappreciated. High cellular respiration rates can rapidly...

biorxiv.org
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FrezzaLab@FrezzaLab16 Oct 2022
This is an interesting protocol for rapid fractionation of mitochondria from @Mito_Redox with some help from us @ASofiaHCosta Rapid fractionation of mitochondria from mouse liver and heart reveals in vivo metabolite compartmentation febs.onlinelibrary.wiley.com…

FEBS Press

To assess the distribution of metabolites between mitochondria and the cytosol, we developed a rapid fractionation procedure. We take mouse heart/liver and within ~ 30 s stabilise the distribution...

febs.onlinelibrary.wiley.com
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Rahul Samant@SamantLab29 Sep 2022
3yr #postdocposition in Cambridge @AstraZeneca, split between their shiny new DISC & our lab @BabrahamInst. Help explore how cellular stresses shape #PROTAC efficacy, & vice-versa. Fundamental/translational relevance aplenty! Oh, some cool #proteomics too. careers.astrazeneca.com/job/… – at Babraham, England
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Join us on July 27th in the next Epigenetics&Metabolism webinar. Dr. Jiangbin Ye from @StanfordMed will tell us about the epigenetic mechanisms involved in the connection between metabolism and cell differentiation. Organized by Wilhelm Palm, @singhilab and @CSebastianLab
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Mary Doan@propionylCoA12 May 2022
Stoked my first-author undergrad project on propionate/valine metabolism is now in press @jlipidres @ASBMB. We found that direct anabolic metabolism of three carbon propionate to a six carbon metabolite occurs in vivo across tissues and species jlr.org/article/S0022-2275(2…
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I'm very happy to be speaking at the next Cambridge Epigenetics Club on May 23rd and equally happy to be sharing the session with @rcollepardo Join us to discuss new perspectives on #chromatin organisation and localisation Do YOU know where your histone are? 😉
CambridgeEpigenetics@EpigeneticsClub9 May 2022
Please join us for the next Cambridge Epigenetics Club with Rosana Collepardo Guevara @rcollepardo and Maria Christophorou @MAChristoLab on May 23rd - in person @CamBiochem and online. Talks start at 530pm with networking and refreshments afterwards.
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New autophagy paper from the White lab with @YangYan55648779 @MaLuciaGomezPhD @PerezPoillet @Aksh1210 @DebnathLabUCSF @RutgersCancer @Ludwig_Cancer @Princeton Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival pnas.org/doi/10.1073/pnas.22…

Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival | PNAS

Autophagy defects are a risk factor for inflammatory bowel diseases (IBDs) through unknown mechanisms. Whole-body conditional deletion of autophagy...

pnas.org
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⌛️20 days to deadline! Please RT. Send us your best abstract before June 1 and join us for the Summer School #Spetses2022 on Cancer Epigenetics - Principles, Applications and Single-cell resolution. More info:🌐intercept-mds.eu/spetses/
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Mary Doan@propionylCoA23 Apr 2022
Krebs annnnnnd another TCA cycle?! Mike and I highlight a newly identified alternative, sub-compartmentalized version of the TCA cycle reported by @paigearnold2 @__btjackson whose engagement is essential for changes in cell state! nature.com/articles/s41422-0…

Krebs and an alternative TCA cycle!

Cell Research - Krebs and an alternative TCA cycle!

nature.com
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Lydia Finley@lydfinley4 Feb 2022
Join us in NYC (or virtually) on April 21 for the annual @NYASciences Cancer Metabolism Symposium! Registration is now open; submit your abstract for an opportunity for a short talk events.nyas.org/event/b759d4…
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ONE WEEK LEFT TO APPLY! Join the soon to be open @trefely lab and investigate metabolite signals linking diet to the epigenome in metabolic disease Apply by 17th January Full job details here: ow.ly/lCBF50H78yz #ScienceJobs #Vacancies #Epigenetics #Metabolism
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Gary Siuzdak@kadzuis27 Feb 2019
All you need to know in one figure. Juliana Ivanisevic @unil & @MartinGiera depict why metabolites are at the center of our biochemical universe nature.com/articles/s41580-0…. Metabolites are the glue that hold the biochemistry together, and drivers that can modulate physiology
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Our new study describing a "potential" mitochondrial glutathione transporter (SLC25A39 and 40). Congrats to all of my amazing lab members and collaborators involved in this work for the last 4 years. @RockefellerUniv @Nature @TriIMDPhD nature.com/articles/s41586-0…
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