@SamantLab

Group Leader @BabrahamInst. He/him. All things #ubiquitin #proteostasis #proteomics #ageing #senescence. Spend too much on food & wine. Opinions mine, all mine!

 Cambridge, UK
samantlab.github.io/
Joined March 2012
  • Tweets3.3K
  • Following1.7K
  • Followers1.7K
298Media
Rahul Samant retweeted
HFSP@HFSP23h
🧬 What does HFSP look for in frontier science? Discover what matters when preparing a Research Grant proposal in our upcoming webinar. 📅 17 Nov | 09:00 & 16:00 CET 🔗 Register: zurl.co/w6Iji #HFSP #ResearchGrants
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Rahul Samant retweeted
GeroScience
@GeroScienceAGE9h
📢 Call for Papers Still Open! 📢 We're inviting submissions on longevity in reproductive tissues — a vital and evolving topic in aging research. 🔬 Explore the details in the comments and submit your work here: 📩 springer.com/journal/11357/u… #ReproductiveAging #Longevity #AgingResearch #CallForPapers
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Online now! Proteasome inhibition bidirectionally regulates ferroptosis sensitivity dlvr.​it/TW0qWp #chembiol
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Rahul Samant retweeted
Manuel Collado@mcollado_CIMUS21h
Don´t miss this fantastic Cell Senescence event in Mexico City next 2027!!! IberoICSA first in-person meeting: 🗓️ March 16–19, 2027 An event with top keynote lectures and invited speakers, and also the opportunity to present your work: smb.org.mx/ibero-icsa-2027/ @Ibero_ICSA
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Bioengineering's gift to AI isn't another algorithm. It's more life-like cell cultures to learn from. LigHTS, now out in Advanced Science, makes soft, microstructured hydrogels directly in standard 1536-well plates, every well in a single 16-min light exposure. 🧵
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Rahul Samant retweeted
The Cuervo Lab@AMCuervoLabOct 20
🗞️🚨 Chaperone-mediated autophagy curbs senescence Check out the News and Views written by Shweta S. Dipali and @MattYousefzadeh about our most recent article. Thank you so much! nature.com/articles/s43587-0…

Chaperone-mediated autophagy curbs senescence

Nature Aging - Sereda and colleagues show that chaperone-mediated autophagy declines with aging, which leads to enhanced senescent cell burden that is driven, in part, by failed macrophage-mediated...

nature.com
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Rahul Samant retweeted
Abcam
@abcamOct 16
Join us for the next InflammaZoom session on October 27, 2026. There's still time to register and be part of the discussion.​ Hear from:​ ✔️Daniel Fisch (Gulbenkian Institute for Molecular Medicine (GIMM)) on 'Building Myddosomes: Innate Immune Signaling Organelles in the TLR Pathway'​ ​✔️Isabella Rauch (Oregon Health & Science University) on 'Eicosanoid signals in inflammasome-induced intestinal epithelial cell extrusion'​ ​Chaired by Avinash Shenoy (Imperial College London), this session brings together leading researchers to share discoveries and advance discussions in innate immune research. ​ Register now: events.abcam.com/event/Infla…
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Spatial protein quality control requires a functional GET pathway to prevent proteotoxicity biorxiv.org/content/10.64898…

Spatial protein quality control requires a functional GET pathway to prevent proteotoxicity

The proper management of misfolded proteins is an essential biological process that is required for the survival of all organisms. Previous work has demonstrated that misfolded proteins can be...

biorxiv.org
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Senescent Fibroblasts Impair B Cell Proliferation via Cell–Cell Contact onlinelibrary.wiley.com/doi/…

Senescent Fibroblasts Impair B Cell Proliferation via Cell–Cell Contact

Tonsil-derived fibroblasts support B cell activation and proliferation in response to stimulation in ex vivo 3D co-culture. However, when rendered senescent using bleomycin, tonsil-derived fibrobla...

onlinelibrary.wiley.com
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Rahul Samant retweeted
ShorterLab@ShorterLabOct 14
Serine-65 phosphorylated ubiquitin associates with soluble tau and seeding activity in Alzheimer’s disease: nature.com/articles/s41467-0…

Serine-65 phosphorylated ubiquitin associates with soluble tau and seeding activity in Alzheimer’s...

Nature Communications - Not all selective markers of seeding-competent Tau are known. Here, the authors identify pS65-Ub-associated tau linked to pathological Tau spreading and elevated in...

nature.com
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Rahul Samant retweeted
ShorterLab@ShorterLabOct 14
Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis: science.org/doi/10.1126/scit…

Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis

Microglia clear intraneuronal α-synuclein aggregates.

science.org
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Cellular senescence: six decades of discovery and reinvention link.springer.com/article/10…

Cellular senescence: six decades of discovery and reinvention

The EMBO Journal - Cellular senescence has undergone a remarkable conceptual evolution since its discovery in 1961. Initially described by Hayflick and Moorhead as the finite proliferative lifespan...

link.springer.com
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Tomorrow: "Honoring Carlos Bustamante at 75: Foundational Contributions to Single-Molecule Biophysical Research in Latin America". Registration: sbbmch.cl/simposio-en-honor-… Organized by Universidad de Chile, ex-students and collaborators.
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Rahul Samant retweeted
ShorterLab@ShorterLabOct 13
A Human Neuronal Cell Model of Endogenous TDP-43 A315T Reveals Altered Protein Dynamics and Disease-Relevant Cellular Dysfunction biorxiv.org/content/10.64898…

A Human Neuronal Cell Model of Endogenous TDP-43 A315T Reveals Altered Protein Dynamics and...

TAR DNA-binding protein 43 (TDP-43) aggregation is the defining pathological hallmark of nearly all cases of amyotrophic lateral sclerosis (ALS), yet physiologically relevant human models that...

biorxiv.org
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Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection nature.com/articles/s41467-0…

Cell senescence emerges as a hallmark and therapeutic target of chronic intracellular infection

Nature Communications - The study identified Mycobacterium abscessus-induced DNA damage as a driver of senescence through reprogramming of alveolar macrophages. Treatment of navitoclax in chronic...

nature.com
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Rahul Samant retweeted
Waggoner Lab@LabWaggonerOct 13
Intestinal inflammation leaves a durable imprint in the extracellular matrix that redirects stem-cell fate, sustains wound-associated epithelial programs and promotes persistent immune activation @ImmunityCP cell.com/immunity/fulltext/S… cell.com/immunity/fulltext/S…
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Rahul Samant retweeted
Uri Alon@UriAlonWeizmannOct 13
Our Nature Medicine paper is out: menopause isn't a slow slope. Across 300M+ lab tests from 1M+ women, many body systems jump at the final menstrual period. Men show no such jump. 1/4 nature.com/articles/s41591-0…

Population-scale reconstruction of menopause dynamics reveals a physiological cliff at the final...

Nature Medicine - By using a novel computational framework, a cross-sectional analysis on laboratory data from two independent cohorts reveals that the final menstrual period marks an abrupt,...

nature.com
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Rahul Samant retweeted
Verena Kohler@_VerenaKohlerOct 13
Looking for a postdoc interested in ageing biology and proteostasis 📅 Deadline: Nov 15 More details in attached document #Postdoc #PostdocOpportunity #Proteostasis #LongevityResearch #AcademicJobs #ResearchJobs
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Rahul Samant retweeted
Aging Journal@AgingJrnlOct 13
Aging’s Special Collection on Cell Senescence and Rapamycin: aging-us.com/special-collect… #aging #senescence #rapamycin #research #science #meded #openaccess #publications

Peer-Reviewed Aging Research Journal | Aging

Aging-US is a primarily aging-focused, peer-reviewed, open-access journal.

aging-us.com
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A conserved post-maturity imbalance between housekeeping and integrative genome activity in aging link.springer.com/article/10…

A conserved post-maturity imbalance between housekeeping and integrative genome activity in aging

GeroScience - Aging biology still lacks a fully mechanistic explanation for why functional decline accelerates after sexual maturity in the absence of a single initiating pathology. Here, we...

link.springer.com
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