Will Barr (@will_barrcode) header
Will Barr (@will_barrcode) profile picture
Joined December 2020
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Nature is healing
“It’s the only class I took at Harvard where people would call each other out for not having done the reading.” Harvard students are lining up to take Hum 10: “Applications (essays required) shot up 40% this fall with 180 incoming freshmen vying for 90 spots.” “The class is definitely not for padding the GPA. Students read a hefty book a week and write regular essays. There is no pass/fail option. Digital devices are verboten, and attendance is taken in every lecture (pink slips for those who arrive late).” “In their applications and in interviews, students expressed the urge to be forced to tackle classics they otherwise wouldn’t read, the need to combat frayed attention spans and the desire for an antidote to The Machine. Several mentioned with disdain that people who aren’t in the class wondered why they didn’t ‘just Chat the books,’ i.e., use AI.”
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Thrilled to share that our work reconstructing a cell fate map of the mouse embryo is out now in @CellCellPress! doi.org/10.1016/j.cell.2026.…
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Metaphor for the average conversation in Cambridge, MA
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Everyone should read The Moth Snowstorm
Around the world, the total toxicity and ecological harm from agricultural pesticides are rising, despite recent United Nations commitments to halve pesticide use and risks by 2030, according to a new study in Science. The findings establish a global, toxicity-weighted baseline for pesticide use and identify a subset of pesticides, crops, and countries driving the most biodiversity impacts. scim.ag/3ZXmwxL
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Will Barr retweeted
I bet 95% of 30 minute video calls could be five minute phone calls.
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Slop is the absence of intelligence. There is no AI slop. Just slop
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we must make number go up to win
The U.S. is losing its competitive advantage in scientific research. This new working paper uses 44 million publications and shows a massive global shift: -Since 1980, the U.S. share of scientific output has fallen from ~40% to 15%. -In that time period, China has risen from near 0 to ~32% overall. -This is also true in top-journal papers. -This isn’t just more scientists; it's higher per-researcher productivity. The U.S. still leads in biomedical science. China now dominates engineering & physical sciences. Bottom line: Global science is democratizing. U.S. scientific dominance is no longer guaranteed.
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No more slop papers
The U.S. is losing its competitive advantage in scientific research. This new working paper uses 44 million publications and shows a massive global shift: -Since 1980, the U.S. share of scientific output has fallen from ~40% to 15%. -In that time period, China has risen from near 0 to ~32% overall. -This is also true in top-journal papers. -This isn’t just more scientists; it's higher per-researcher productivity. The U.S. still leads in biomedical science. China now dominates engineering & physical sciences. Bottom line: Global science is democratizing. U.S. scientific dominance is no longer guaranteed.
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A study in @ScienceMagazine from Paul Cohen's lab, led by @KoenenMascha, demonstrates how beige fat directly influences blood pressure. The findings offer a new target for treating vascular disease and could lead to more precise therapies for hypertension: rockefeller.edu/news/38906-h…
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No more slop papers
Two business school professors from the University of Technology in Sydney have sounded the alarm on the declining quality of academic literature in a new publication titled “The junkification of research”. Drawing parallels to the “enshittification” of online platforms, they argue that similar forces are now overwhelming scholarly publishing. The key drivers are threefold: 1) relentless “publish or perish” pressures in academia, 2) scientific publisher’s incentive to publish more to make more money, and 3) AI making paper production faster and easier. Taken together, they say, these drivers are a recipe for disaster. The authors call for a shift to not-for-profit models of scientific publishing and better evaluation systems. I strongly doubt either is going to happen. The problem is of course not new, and you all know that I have been drawing attention to this trend for more than a decade. It is interesting to see, however, that the awareness for the issue is increasing. Paper: Rhodes, C., & Linnenluecke, M. K., “The junkification of research” Organization (2025).
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Will Barr retweeted
Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.
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Will Barr retweeted
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of @MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be.
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I love MIT The @MITBananaLounge shipped 812,000 bananas last year and only 0.7% bananas went to waste, which I wonder may be less than an average grocery store
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It’s almost as if hyperlocal cooperative food distribution is less wasteful 🤯
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Always wondered how much this might contribute to control of mammalian body temperature -- degradation gated control as a means of futile cycling
Protein synthesis is among the most energy demanding processes in a cell. Why are then some proteins continuously synthesized and immediately degraded ? blog.slavovlab.net/2025/08/1…
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Will Barr retweeted
We need experimental abundance in bioengineering. So much of biological science is trying to squeeze as much learning as possible out of a very small amount of raw experimental data -- because making that data is insanely expensive. We're hitting the limits of that approach -- this is why drug discovery gets more expensive every year, not less. We've unlocked experimental abundance in genomics (reading DNA) but nowhere else yet in a general way -- especially once you include any DNA design in the mix. Need to really get to work on this problem !!
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You’re in great hands America! Here are the 2025 Harvard/MIT MD-PhD graduates who have dedicated their lives to providing the best care to your families & delivering you medical cures from their groundbreaking science. @NIH @NIHDirector_Jay @HHSGov @SecKennedy @harvardmed @MIT
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More exciting results for AI binder design 🧬 New work from the Ovchinnikov Lab at MIT builds on the open-source Boltz1 structure prediction model (from another MIT lab) for in silico design of a wide variety of binders. For computational benchmarks, appears to outperform RFDiffusionAA. Repo isn't live yet, but when it is, should be a great new pillar to build on. Crazy pace of progress!
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Check out @WhiteheadInst's symposium – AI: Advancing Foundational Biology – today (Tuesday, April 8), from 2-5:00 p.m., followed by a poster session and reception at 5 p.m. @Schmidt_Center Director Caroline Uhler will be keynoting at 2:15 p.m. Learn more: calendar.mit.edu/event/ai-ad…
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