Will Barr retweeted
Thrilled to share that our work reconstructing a cell fate map of the mouse embryo is out now in @CellCellPress! doi.org/10.1016/j.cell.2026.…
Will Barr retweeted
A study in @ScienceMagazine from Paul Cohen's lab, led by @KoenenMascha, demonstrates how beige fat directly influences blood pressure. The findings offer a new target for treating vascular disease and could lead to more precise therapies for hypertension: rockefeller.edu/news/38906-h…
Will Barr retweeted
Rest in peace Jane Goodall, a true giant among scientists. Your breakthroughs into the secret lives of chimpanzees viewed through an anthropomorphic lens – without yet knowing that science had forbidden it – changed science forever, and with it how we see ourselves.
Will Barr retweeted
Legend David Baltimore died yesterday. He understood the way things should work: "the real contribution of @MIT is that it doesn't take itself too seriously. It takes ideas seriously, but the people are relatively informal. They are not self-aggrandizing the way academics can be.
Will Barr retweeted
We need experimental abundance in bioengineering.
So much of biological science is trying to squeeze as much learning as possible out of a very small amount of raw experimental data -- because making that data is insanely expensive. We're hitting the limits of that approach -- this is why drug discovery gets more expensive every year, not less.
We've unlocked experimental abundance in genomics (reading DNA) but nowhere else yet in a general way -- especially once you include any DNA design in the mix.
Need to really get to work on this problem !!
Will Barr retweeted
You’re in great hands America! Here are the 2025 Harvard/MIT MD-PhD graduates who have dedicated their lives to providing the best care to your families & delivering you medical cures from their groundbreaking science. @NIH @NIHDirector_Jay @HHSGov @SecKennedy @harvardmed @MIT
Will Barr retweeted
More exciting results for AI binder design 🧬
New work from the Ovchinnikov Lab at MIT builds on the open-source Boltz1 structure prediction model (from another MIT lab) for in silico design of a wide variety of binders.
For computational benchmarks, appears to outperform RFDiffusionAA.
Repo isn't live yet, but when it is, should be a great new pillar to build on.
Crazy pace of progress!
Will Barr retweeted
Check out @WhiteheadInst's symposium – AI: Advancing Foundational Biology – today (Tuesday, April 8), from 2-5:00 p.m., followed by a poster session and reception at 5 p.m. @Schmidt_Center Director Caroline Uhler will be keynoting at 2:15 p.m. Learn more: calendar.mit.edu/event/ai-ad…
Will Barr retweeted
New review out today in Nature Biotech on nanopore-based protein sequencing.
Feels... like... something... coming... soon... 👀
Will Barr retweeted
Check out the latest work led by @MatthewHarryHa1 in the Bartel lab! Matt solved a long-standing mystery about miRNA targeting, and drove the story to impressive mechanistic detail (1/2)
Will Barr retweeted
If 350 donors give to the School of Science today, MIT Biology alumna Dyann Wirth, PhD ’78, will make a $100,000 gift. Help us secure the future of fundamental discovery today!
Will Barr retweeted
The Volkswagen Foundation has a new "Night Science" funding mechanism (!) for "teams of 2 researchers who inspire, complement and challenge each other. The aim is to create a space in which new approaches can emerge - without the pressure to produce immediate results." AMAZING!
Will Barr retweeted
Our story “A torpor-like state in mice (TLS) slows blood epigenetic aging and prolongs healthspan” is now out: nature.com/articles/s43587-0…
Big congrats to
@LornaLJayne, Aurora Lavin-Peter, and Julian Roessler,
and thanks to
@prof_horvath, @bloodgenes, @VadimGladyshev, and others.
Will Barr retweeted
We made the cover of Genome Research! Check out our latest paper on DDX3X and DDX3Y - the first X-Y gene pair with cross regulatory capabilities (genome.cshlp.org/content/35/…).
Will Barr retweeted
I went to a talk during MIT’s career fair week circa 2017 where the speaker strongly made the case that over the next decade we would see an extreme oversupply of people with CS backgrounds but an extreme undersupply in domain experts with CS skills.
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Will Barr retweeted
Really excited to finally share a little of what we've been working on the last few years! using a new generative model we designed binders against seven targets that reach low-nano/picomolar affinity.
We’re presenting AlphaProteo: an AI system for designing novel proteins that bind more successfully to target molecules. 🧬
It could help scientists better understand how biological systems function, save time in research, advance drug design and more. 🧵 dpmd.ai/3XuMqbX
Will Barr retweeted
I am very excited to share our story on genetic mechanisms of cellular cold tolerance.
Congratulations to Breanna Lam, Kat Kajderowicz @katclone, and collaborators @HeatherKPhD @genfren @MohamedBrolosy @JswLab
biorxiv.org/content/10.1101/…
