@CHLinusEng

Pushing the boundaries of spatial genomics. Developer of seqFISH+.

Joined October 2016
  • Tweets66
  • Following62
  • Followers88
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Linus Eng retweeted
Yodai Takei@yodai_takeiSep 2
Happy to share the published version of our work on chromatin recording with LagTag! cell.com/cell-systems/abstra…

Genome-wide chromatin recording resolves dynamic cell state changes

Takei et al. introduce LagTag, a chromatin-based recording strategy for mammalian cells. Past chromatin states are recorded by time-gated m6A writing and recovered alongside present states from the...

cell.com
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Cai Lab@LongCai_LabAug 18
Quality of the data matters! at least for predicting glioma progression from a patient's initial biopsy before any progression has occurred. Excited to share our new pre-print, authored by Michal Polonsky, Jonathan Fox, Yunrui Lu and Sheel Shah. (1/7) biorxiv.org/content/10.64898…
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Linus Eng retweeted
Yodai Takei@yodai_takeiJul 20
We are inviting applications for a Postdoctoral Fellow/Scientist I (Cell Engineering) to join our growing team at Biohub NY's Lab of Synthetic Spatial Omics and work together! @biohub Please help spread the word🙏 job-boards.greenhouse.io/bio…

Biohub

job-boards.greenhouse.io
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Linus Eng retweeted
Cai Lab@LongCai_LabMay 27
Thrilled to share our @CellCellPress paper with Shosei Yoshida & Ben Simons, led by @ChakraArun: 1) spatial geometry can resolve temporal dynamics 2) Sertoli cells run an intrinsic cycle coupled to germline, suggesting oscillator coupling as a principle of tissue organization
Arun Chakravorty@ChakraArunMay 27
Our paper is finally out in Cell! Years of work on one of biology's most beautiful tissue clocks, and finding an intrinsic oscillator that helps organize tissue dynamics. From my PhD work at @LongCai_Lab, with Shosei Yoshida and Ben Simons! 🧵(1/10) cell.com/cell/fulltext/S0092…
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Our paper is finally out in Cell! Years of work on one of biology's most beautiful tissue clocks, and finding an intrinsic oscillator that helps organize tissue dynamics. From my PhD work at @LongCai_Lab, with Shosei Yoshida and Ben Simons! 🧵(1/10) cell.com/cell/fulltext/S0092…
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Linus Eng retweeted
Yodai Takei@yodai_takeiApr 30
I'm very excited to share that I've started a new position as a Group Leader at CZ Biohub NY! @biohub
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Linus Eng retweeted
Ruben Dries@RnDries1 Oct 2025
Very proud to finally publish Giotto Suite after many years of hard work. It's a big milestone for our lab and will be a massive stepping stone for our ongoing projects and ideas. Take a look at giottosuite.com and feel free to share feedback and ideas for improvement.
Giotto@GiottoSpatial1 Oct 2025
Thrilled to announce our new Nature Methods paper: Giotto Suite: an extensible, technology-agnostic ecosystem for spatial multiomics analysis. Big thanks to co-first authors @jiaji_g_chen & @josschavezf1, and all Giotto devs in @RnDries & @gc_yuan labs! nature.com/articles/s41592-0…

Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem

Nature Methods - Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R.

nature.com
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I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. biorxiv.org/content/10.1101/…
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New online! Spatial multi-omics of nuclear architecture with two-layer seqFISH+ bit.ly/46eTdez
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I'm happy to share a highlight from our recent work!
Nature Reviews Genetics@NatureRevGenet25 Jun 2025
New online! Spatial multi-omics of nuclear architecture with two-layer seqFISH+ bit.ly/46eTdez
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In #SpatialBiology news, a preprint on CKD using seqFISH. A little explainer below on Chronic Kidney Disease. biorxiv.org/content/10.1101/…
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Linus Eng retweeted
Caltech@Caltech4 Oct 2022
Congratulations to @LongCai_Lab, @mhofflab, @davidvanvalen, Kai Zinn, and Matt Thomson! These five researchers have been awarded grants from the High-Risk, High-Reward Research (HRHR) Program of the National Institutes of Health (@NIH). 👏 caltech.edu/about/news/five-…

Five Caltech Researchers Receive High-Risk, High-Reward Awards

Four faculty members and one postdoctoral scholar have received grants from the High-Risk, High-Reward Research (HRHR) Program of the National Institutes of Health.

caltech.edu
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clampFISH 2.0 enables rapid, scalable amplified RNA detection in situ biorxiv.org/cgi/content/shor… #bioRxiv
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Linus Eng retweeted
nature
@Nature21 Feb 2022
Revealing chromosome contours, one dot at a time go.nature.com/3tf03Mf
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Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? In our new preprint we explore how these features are balanced to ensure target specificity and robust gene regulation via a spatial amplification mechanism (biorxiv.org/content/10.1101/…)

Xist spatially amplifies SHARP recruitment to balance chromosome-wide silencing and specificity to...

Although thousands of lncRNAs are encoded in mammalian genomes, their mechanisms of action are largely uncharacterized because they are often expressed at significantly lower levels than their...

biorxiv.org
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Our work is out in @ScienceMagazine! Using integrated spatial genomics technology, we have extensively investigated the single-cell nuclear architecture across cell types in the mouse brain cortex with a great team @LongCai_Lab @gc_yuan @swzheng29 #seqFISH science.org/doi/10.1126/scie…

Single-cell nuclear architecture across cell types in the mouse brain

Multimodal measurements in single cells in the brain reveal nuclear organization principles across cell types.

science.org
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Linus Eng retweeted
Cai Lab@LongCai_Lab7 Sep 2021
Our work "Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis" is now out at @NatureBiotech ! Congratulations to all the authors! nature.com/articles/s41587-0… #seqfish #spatial #singlecell #transcriptomics

Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis

Nature Biotechnology - Improved integration of spatial and single-cell transcriptomic data provides insights into mouse development.

nature.com
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Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis go.nature.com/3DRM6rY
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Hello friends! We are pleased to report that spatialgenomics.com is now live. Come take a look and learn a bit more about our technology, applications, team, publications, and open positions. #spatialgenomics #Genomics
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Linus Eng retweeted
Caltech@Caltech18 Aug 2021
A new technique developed at Caltech can examine the behavior of myriad microbial communities on our planet, from those deep under the ocean to those living in our gut, by surveying gene expression across a huge number of cells. caltech.edu/about/news/new-t…

New Technique Surveys Microbial Spatial Gene Expression Patterns

Communities of microbes around the world can now be understood with a new technique to visualize gene expression.

caltech.edu
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