@CHLinusEng

Pushing the boundaries of spatial genomics. Developer of seqFISH+.

Joined October 2016
  • Tweets66
  • Following62
  • Followers88
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Replying to @yodai_takei
Congratulations Yodai!
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Linus Eng retweeted
Yodai Takei@yodai_takeiSep 2
Happy to share the published version of our work on chromatin recording with LagTag! cell.com/cell-systems/abstra…

Genome-wide chromatin recording resolves dynamic cell state changes

Takei et al. introduce LagTag, a chromatin-based recording strategy for mammalian cells. Past chromatin states are recorded by time-gated m6A writing and recovered alongside present states from the...

cell.com
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Cai Lab@LongCai_LabAug 18
Quality of the data matters! at least for predicting glioma progression from a patient's initial biopsy before any progression has occurred. Excited to share our new pre-print, authored by Michal Polonsky, Jonathan Fox, Yunrui Lu and Sheel Shah. (1/7) biorxiv.org/content/10.64898…
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Yodai Takei@yodai_takeiJul 20
We are inviting applications for a Postdoctoral Fellow/Scientist I (Cell Engineering) to join our growing team at Biohub NY's Lab of Synthetic Spatial Omics and work together! @biohub Please help spread the word🙏 job-boards.greenhouse.io/bio…

Biohub

job-boards.greenhouse.io
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Replying to @ChakraArun @sciam @Caltech @LongCai_Lab
Thanks 🙏!!
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Replying to @arjunrajlab
😆thank you for your kind words Arjun!
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I am honored to be selected as one of the Young American Scientists by @sciam for developing seqFISH+ in the spatial biology field at @Caltech with @LongCai_Lab. Read more about our work and explore the full cohort profiles here: sciam.com/youngscientists #SciAmYoungScientists
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Cai Lab@LongCai_LabMay 27
Thrilled to share our @CellCellPress paper with Shosei Yoshida & Ben Simons, led by @ChakraArun: 1) spatial geometry can resolve temporal dynamics 2) Sertoli cells run an intrinsic cycle coupled to germline, suggesting oscillator coupling as a principle of tissue organization
Arun Chakravorty@ChakraArunMay 27
Our paper is finally out in Cell! Years of work on one of biology's most beautiful tissue clocks, and finding an intrinsic oscillator that helps organize tissue dynamics. From my PhD work at @LongCai_Lab, with Shosei Yoshida and Ben Simons! 🧵(1/10) cell.com/cell/fulltext/S0092…
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Our paper is finally out in Cell! Years of work on one of biology's most beautiful tissue clocks, and finding an intrinsic oscillator that helps organize tissue dynamics. From my PhD work at @LongCai_Lab, with Shosei Yoshida and Ben Simons! 🧵(1/10) cell.com/cell/fulltext/S0092…
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Congratulations Arun! this is very interesting to read!
Arun Chakravorty@ChakraArunMay 27
Our paper is finally out in Cell! Years of work on one of biology's most beautiful tissue clocks, and finding an intrinsic oscillator that helps organize tissue dynamics. From my PhD work at @LongCai_Lab, with Shosei Yoshida and Ben Simons! 🧵(1/10) cell.com/cell/fulltext/S0092…
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Linus Eng retweeted
Yodai Takei@yodai_takeiApr 30
I'm very excited to share that I've started a new position as a Group Leader at CZ Biohub NY! @biohub
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Replying to @yodai_takei @biohub
Congratulations Yodai! this is exciting!
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Excited to see this out!
IdoAmitLab@IdoAmitLabApr 24
Beautiful work @garber_manuel and co. Immunology is magical! nature.com/articles/s41590-0…

A spatially coordinated keratinocyte–fibroblast circuit recruits MMP9+ myeloid cells to drive type...

Nature Immunology - Wang, Afshari, Haddadi and colleagues compare UVB-sensitive and insensitive human skin diseases and show that photosensitive conditions, including cutaneous lupus erythematosus...

nature.com
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Linus Eng retweeted
Ruben Dries@RnDries1 Oct 2025
Very proud to finally publish Giotto Suite after many years of hard work. It's a big milestone for our lab and will be a massive stepping stone for our ongoing projects and ideas. Take a look at giottosuite.com and feel free to share feedback and ideas for improvement.
Giotto@GiottoSpatial1 Oct 2025
Thrilled to announce our new Nature Methods paper: Giotto Suite: an extensible, technology-agnostic ecosystem for spatial multiomics analysis. Big thanks to co-first authors @jiaji_g_chen & @josschavezf1, and all Giotto devs in @RnDries & @gc_yuan labs! nature.com/articles/s41592-0…

Giotto Suite: a multiscale and technology-agnostic spatial multiomics analysis ecosystem

Nature Methods - Giotto Suite provides a comprehensive, flexible and scalable platform for technology-agnostic spatial omics analysis using R.

nature.com
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I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. biorxiv.org/content/10.1101/…
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New online! Spatial multi-omics of nuclear architecture with two-layer seqFISH+ bit.ly/46eTdez
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I'm happy to share a highlight from our recent work!
Nature Reviews Genetics@NatureRevGenet25 Jun 2025
New online! Spatial multi-omics of nuclear architecture with two-layer seqFISH+ bit.ly/46eTdez
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Congratulations Yodai! this is amazing in both the technology advancement as well as discovering novel nuclear biology!
Yodai Takei@yodai_takei10 Apr 2025
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! nature.com/articles/s41586-0…

Spatial multi-omics reveals cell-type-specific nuclear compartments

Nature - A genomic barcoding scheme called two-layer DNA seqFISH+ enables the simultaneous mapping of more than 100,000 loci and has been used to identify cell-type-specific subnuclear compartments...

nature.com
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