Postdoc @sangerinstitute @UCL respiratory｜PhD & MSc in Cancer Genomics @UCL @uclcancer | Medicine & Math @PKU1898 | Cancer evolution | violinist 👩🔬🎻
London, England
Joined November 2018
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Chuling Ding retweeted
Very excited to release Sequoia, our pipeline for phylogenetic tree reconstruction from mutations in normal cells. A detailed description is now published in @NatureProtocols! nature.com/articles/s41596-0…
Chuling Ding retweeted
Thrilled to welcome @JavierHerrero7 as the Project Director of Bioinformatics at @AsgardThx. With 25 years of expertise, Javier will play a key role in identifying genetic and epigenetic factors for reprogramming and treatment efficacy.🌟
Welcome to the team, Javier!
Chuling Ding retweeted
From @Nature - Why we need an academic career path that combines science and art: nature.com/articles/d41586-0…
A thought provoking discussion on the relationship between science and art. The science-art dichotomy has always seemed arbitrary to me
Chuling Ding retweeted
CONIPHER, our method for automated reconstruction of tumour subclonal structure and phylogeny that we used in our recently published TRACERx studies, is now out in Nature Protocols! (nature.com/articles/s41596-0…). Welcome to the CONIPHER TREEtorial, just in time for Christmas! 🌲 1/n
Chuling Ding retweeted
Excited to share the first preprint of my PhD @sangerinstitute looking into the prevalence and genetic mechanisms of gene misexpression in 4,568 whole blood RNA-seq samples from the INTERVAL cohort. biorxiv.org/cgi/content/shor…
Chuling Ding retweeted
Spatial host–microbiome sequencing reveals niches in the mouse gut go.nature.com/3sGmJbU
Chuling Ding retweeted
Our latest paper: measurement of cancer evolutionary dynamics at massive scale, using just a methylation array on bulk DNA. Find evolutionary dynamics strongly determine clinical outcomes in lymphoid cancers. Fab collab with Inaki Martin & @Marti_DF, & led by @CalumGabbutt. A🧵⬇️
Does the evolutionary history of a cancer predict outcome? In our pre-print, we introduce a new method to measure a cancer’s past using bulk methylation data. In chronic lymphocytic leukaemia (CLL), these inferred histories are highly prognostic! (1/9)
doi.org/10.1101/2023.11.10.2…
Chuling Ding retweeted
Can everyone please congratulate Dr @ChulingD on being awarded her #PhD in Cancer Genomics?
Inquisitive, systematic and driven, this PhD is so well deserved. Congrats Chuling!
@uclcancer @uclmedsci
Chuling Ding retweeted
Johns Hopkins is offering FREE research courses online.
Here are 10 courses you can audit to elevate your skills (links below):
Chuling Ding retweeted
Very excited to see our study on a case of ALL to AML switch after CAR-T treatment out in @NatureCancer! Using deep genome sequencing, we show the cancer switched cell types to escape therapy.
@broadinstitute @sangerinstitute @getz_lab
Thread below 🧵
nature.com/articles/s43018-0…
Chuling Ding retweeted
Excited to announce our new method HATCHet2 for inferring haplotype- and clone-specific copy number from bulk samples! HATCHet2 extends HATCHet to infer mirrored-subclonal CNAs, and introduces new binning and clustering approaches.
biorxiv.org/content/10.1101/…
Chuling Ding retweeted
June really appears to be my lucky month - our new preprint is out on @researchsquare! 😍 Together with @doctor_msc, @andrewrjlawson and many others we looked into the life history of mitochondria in the human haematopoietic system researchsquare.com/article/r…. [1/x]
Chuling Ding retweeted
Happy to share our work looking at induction failure in childhood and young adult T-ALL. A short thread on the main findings….
ascopubs.org/doi/10.1200/JCO…
Chuling Ding retweeted
Can ctDNA can be harnessed to identify ongoing karyotype evolution and heterogeneity in pancreatic cancer? Great work from @jrm_black @AMIHuebner …thread👇
📢Our paper ‘ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA’ is out in @GenomeMedicine.
Led by @AMIHuebner and myself, supervised by @NickyMcGranahan & a collaboration with Rodrigo Toledo & @DrMhidalgo. 🧵(1/9) genomemedicine.biomedcentral…
Chuling Ding retweeted
Today, @nature and @NatureMedicine are proud to publish amazing new insights into lung cancer evolution from the #TRACERx consortium. Updated collection: nature.com/collections/haffg… Great author threads👇
Chuling Ding retweeted
Opening patient evening @uclcancer, supported by
@CRUKCOLcentre. Loads of enthusiastic volunteers from @Marcrmansour, @christophertape @Parrinello_Lab, @QuezadaLab, Sibylle Mittnacht and more labs made it possible, may this be the beginning of a new PPIE movement @uclcancer?
Chuling Ding retweeted
'Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers'
nature.com/articles/s43018-0…
Chuling Ding retweeted
Our recent @SwantonLab work on the genomic evolution of lung cancer patient-derived xenograft (PDX) models in TRACERx is now @biorxivpreprint 🐁
biorxiv.org/content/10.1101/…
#PDXmodels #cancerresearch #lungcancer #NSCLC
A short thread (1/6) 🧵👇
Chuling Ding retweeted
Look at this cover 😍! Originally created for our @NatureCancer paper a year ago is now on the front page of this week's #MathOnco newsletter. Created ENTIRELY in R by the super talented @JavierHerrero7. To celebrate, we have a new "behind the paper" piece go.nature.com/3dv0KtF
Chuling Ding retweeted
We have expanded our previous method of copy number signatures developed in sarcomas to identify a reference set of pan-cancer copy number signatures. These are available on @cosmic_sanger
now! 1/2
nature.com/articles/s41586-0…
