Senior Group Leader, CRUK Scotland Institute Fascinated with #CancerEvolution, developmental origins of disease #SingleCellTranscriptomics #Epigenomics
The Northern Lights!
Joined May 2015
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Ramanuj Dasgupta retweeted
Wonderful to see this Roadmap ‘Towards a reference cell atlas of liver diversity over the human lifespan’ in @NatRevGastroHep. It reveals how the HCA Liver Biological Network is creating the Human Liver Cell Atlas, including challenges and potential impact on disease research.
Towards a reference cell atlas of liver diversity over the human lifespan
Human Liver Cell Atlas (HLiCA) roadmap paper is out in @NatRevGastroHep
Led by Sarah Taylor, @garybader1 @MacparlandSonya & Alan Mullar
rdcu.be/eKKz0
Ramanuj Dasgupta retweeted
The Roadmap of the Human Liver Cell Atlas is out in @NatRevGastroHep laying out the scope and goals of our Human Liver Cell Atlas emerging from the @czi funded Liver Seed Network.
nature.com/articles/s41575-0…
Ramanuj Dasgupta retweeted
Online now: CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer dlvr.it/TJzNtX
Ramanuj Dasgupta retweeted
cell.com/cell-reports-medici… Excited to share this latest study from the lab. Kudos to Shumei and the team on establishing a precision oncology paradigm (CAN-Scan) with real-world impact and significance for colorectal cancer patients in the clinic.
Ramanuj Dasgupta retweeted
Thrilled to share our latest collaboration with @DasguptaRam's lab! @nokcs @rafaelperes
CAN-Scan: A multi-omic phenotype-driven precision oncology platform identifies prognostic biomarkers of therapy response for colorectal cancer: Cell Reports Medicine cell.com/cell-reports-medici…
cell.com/cell-reports-medici… Excited to share this latest study from the lab. Kudos to Shumei and the team on establishing a precision oncology paradigm (CAN-Scan) with real-world impact and significance for colorectal cancer patients in the clinic.
Ramanuj Dasgupta retweeted
🚨Subgroups left us speechless 🤯
@NatalieFisher03 of @QUBelfast gave a fascinating talk on distinct transcriptional and phenotypic states within colorectal polyps!
#BowelCancer #ColorectalCancer #Research #CRCThemeDay2025
Pembrolizumab with or without bevacizumab in platinum-resistant recurrent or metastatic NPC: a randomised, open-label, phase 2 trial - The Lancet Oncology thelancet.com/journals/lanon… Super excited to be part of this story with Prof. Goh Boon Cher. Stay tuned for more...!
pubmed.ncbi.nlm.nih.gov/3962… Happy to share @dmuliaditan's work with Lih Feng's lab at NUS, where we employ snCut&Run to demonstrate how intratumor epigenetic heterogeneity can predispose subclonal populations to adapt to distinct selective pressures to drive tumor progression.
Looking forward to an exciting few days of awesome science at the Multi-Omics meeting, Brisbane. Thanks @aruthak for being such an amazing host!!
Humbled and grateful for this editorial on our study defining the single cell landscape of functionally cured chronic Hep B patients. Congrats again @narmada_bc @KhAk_AaT @Niranjan_says!! journal-of-hepatology.eu/art…
Ramanuj Dasgupta retweeted
Great work in collaboration with @DasguptaRam understanding the immune landscape of functional cure from CHB!
Awesome collaborative effort on defining the single cell landscape of CHB resolution, and the role of CD4-CTLs and innate immunity in driving functional cure. Congrats to @narmada_bc @KhAk_AaT @Niranjan_says @SengGeeLim1 and team!! sciencedirect.com/science/ar…
Ramanuj Dasgupta retweeted
🆕Article in press❕
Single cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity
#OpenAccess here👉journal-of-hepatology.eu/art…
#LiverTwitter
Ramanuj Dasgupta retweeted
Functional cure of chronic HBV infection linked to emergence of cytotoxic CD4 T, activated liver-resident NK cells, specific Kupffer cell subtypes and marginated neutrophils @JHepatology @DasguptaRam
doi.org/10.1016/j.jhep.2024.…
Ramanuj Dasgupta retweeted
Super excited about our paper in @embojournal. This work was lead by my brilliant graduate student @Uttkars91989537. We report that there is a metabolic compartment separation between epidermal keratinocytes and macrophages that exacerbates sterile inflammation! @DBT_inStem
Skin inflammation leads to lactate production that reprograms dermal macrophages, induces M2-like proinflammatory phenotypes, and causes sterile inflammation - with relevance in a psoriasis model!
Uttkarsh Ayyangar, Srikala Raghavan @srikalaraghava1 et al
embopress.org/doi/full/10.10…
Ramanuj Dasgupta retweeted
Absolutely thrilled to share that my Ph.D. work is now published @embojournal. Many thanks to my PI @srikalaraghava1, colleagues, friends, and family. We show that chronic inflammatory skin diseases are exacerbated by an immune-epithelial metabolic crosstalk. 🧵(1/n)
Skin inflammation leads to lactate production that reprograms dermal macrophages, induces M2-like proinflammatory phenotypes, and causes sterile inflammation - with relevance in a psoriasis model!
Uttkarsh Ayyangar, Srikala Raghavan @srikalaraghava1 et al
embopress.org/doi/full/10.10…
Awesome collaborative effort on defining the single cell landscape of CHB resolution, and the role of CD4-CTLs and innate immunity in driving functional cure. Congrats to @narmada_bc @KhAk_AaT @Niranjan_says @SengGeeLim1 and team!! sciencedirect.com/science/ar…
Ramanuj Dasgupta retweeted
Insights into the immunological signature of Chronic Hepatitis B and functional cure. Years of hardwork, some great science and collaborations. @DasguptaRam @Niranjan_says @SengGeeLim1 @KhAk_AaT @giridharanperi2 #Hepatitisb @JHepatology #singlecell #immune @astar_research
Excited to announce the SpACE-Dx joint lab with Nanostring and Next Level Genomics that'll focus on the development & discovery of novel biomarkers & therapeutic targets using spatial multiomics for early interventions/screening strategies. #spatialbiology investors.nanostring.com/new…