@DavidPentonR

Physiologist and a lot more

 Zurich; Switzerland
e-phac.uzh.ch/en.html
Joined April 2018
  • Tweets35
  • Following111
  • Followers59
Congrats @bakhta_f for this amazing work that I have the pleasure to present today! Our new models of Primary Aldosteronism will be useful tools to better understand the disease and to test new therapeutic approaches in the future! @ENSAT_news @goharmonisation @AldolabZ
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We are delighted to announce that it is now possible to assess the functional properties of neurons (IPSC-derived, primary, organoids) using HD-MEAs at the Electrophysiology Facility of UZH. Check out our summary of the services we can offer using this technique. The e-phac team
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Hamburg news: Bridging patient observation to molecular understanding in our molecular disease board: Here revealing a multi-hit model for FSGS by Jan Czogalla @PuellesVictor and team. @HCKH_Hamburg @UKEHamburg @unihh kidney-international.org/art…

Ibrutinib-associated focal segmental glomerulosclerosis and the impact of podocin mutations in...

The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib (IBRU) is essential for treating chronic lymphocytic leukemia (CLL).1 In CLL, BTK inhibition hinders proliferation by actin cytoskeleton...

kidney-international.org
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These kind of measurements allow us to follow network dynamics of #iPSC-derived #neurons, #cardiomyocytes, #brain #organoids, primary neuronal cultures and more. Furthermore, the high-density of electrodes provide information about action potential propagation along neurites
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First data from our HD-MEA setup at #EPHAC! Watch how primary cortical neurons (kindly provided by @SchrattL) fire synchronized bursts of action potentials as soon as at DIV9. Get in touch if you are interested in using this system with your cells. @mxwbio #neuroscience
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Automated patch clamp was originally developed for the pharmaceutical industry, but Thompson et al. repurpose it to investigate functional properties of several sodium channel variants associated with neurodevelopmental disorders bit.ly/47xrSCz #SCN2A #epilepsy
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David Penton retweeted
JCI insight
@JCI_insight25 Jul 2023
Calcineurin regulates aldosterone production via dephosphorylation of NFATC4: buff.ly/3KaB6uu #Endocrinology #Metabolism
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Out now: Calcineurin regulates aldosterone production via dephosphorylation of NFATc4 insight.jci.org/articles/vie… @DavidPentonR @UZH_en @UniBasel_en
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#aldosterone #potassium #hyperkalemia #adrenalgland
Felix Beuschlein@FBeuschlein16 Jun 2023
New mechanisms to regulate aldosterone production - great work by David Penton and associates! Calcineurin regulates aldosterone production via dephosphorylation of NFATc4 asci.altmetric.com/details/1…
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New mechanisms to regulate aldosterone production - great work by David Penton and associates! Calcineurin regulates aldosterone production via dephosphorylation of NFATc4 asci.altmetric.com/details/1…
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Why do hyperkalemic kidney transplant recipients on CNI show no aldosterone response -a question open since a 1983 Lancet paper-seems to have been mechanistically explained. Congrats, @DavidPentonR ! insight.jci.org/articles/vie… 1983 Lancet paper: thelancet.com/journals/lance…

HYPERKALAEMIA IN CYCLOSPORIN-TREATED RENAL ALLOGRAFT RECIPIENTS

Mean serum potassium levels were significantly higher for 9 months in renal allograft recipients receiving cyclosporin than in those receiving prednisolone and azathioprine. Sustained hyperkalaemia...

thelancet.com
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Calcineurin inhibitors and hyperkalemia linkedin.com/posts/davidpent…

#calcineurininhibitor #calcineurin #tacrolimus #hyperkalemia #aldosterone #primaryaldosteronism |...

🔬Tacrolimus and its Link to Hyperkalemia Did you know that tacrolimus, a calcineurin inhibitor, is associated with hyperkalemia? This effect is believed to originate from its impact on the Distal...

linkedin.com
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David Penton retweeted
JASN_News@JASN_News1 Mar 2023
JASN is proud to announce that applications for the 2023–2025 Editorial Fellowship Program are now open! Early career researchers with interest in basic or clinical research are encouraged to apply. For more information, visit bit.ly/JASNEditorialFellowsh… #jnltrain
Learn from the Best Editors in Nephrology. Become a JASN Editorial Fellow. JASN is currently looking for our fifth class of Editorial Fellows. Interested applicants should submit their applications by April 30th. For more information, visit http://bit.ly/JASNEditorialFellowship

ALT Learn from the Best Editors in Nephrology. Become a JASN Editorial Fellow. JASN is currently looking for our fifth class of Editorial Fellows. Interested applicants should submit their applications by April 30th. For more information, visit http://bit.ly/JASNEditorialFellowship

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Impressive throughput from the automated patchclamp @NanionTech presented at #LS2AM23 @LS2_ICMT @LS2Switzerland And there is one just next door in Zurich! Contact the electrophysiology facility @e_phac from University of Zurich for more information.
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Check out our Strategic Scientific Network. Top lineup of first class electrophysiologists e-phac.uzh.ch/en/Team.html

Team

e-phac.uzh.ch
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Webpage coming soon!
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We do in vitro electrophysiology @UZH_en
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News from our facility will be published here regularly
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welcome world!
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New Cover Image of August issue of @AJPRenal. Read full article @JoRDMartins, Andrew M. Hall and colleagues @NccrKidneyCH. Also chosen as #APSselect. Congrats!!! Quantitative intravital Ca2+ imaging maps single cell behavior to kidney tubular structure journals.physiology.org/doi/…
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