We updated our Susztaklabbiobank website susztaklab.com For almost two decades our laboratory has collected and profiled human kidney tissue, paired it with mouse and rat models and with the genetics of millions of people, and built one of the most complete maps of the human kidney that exists. This site is where we share it: genome-wide association results, expression, methylation, protein and open-chromatin maps, single-cell and single-nucleus atlases, spatial transcriptomes and animal-model resources, each in an interactive browser you can query today. Please send your suggestions how we could improve our site. Let's cure kidney disease together !

We confirmed this three ways: spatial data (CosMx and Xenium) showed proximal tubule markers inside fetal renal corpuscles, and Confetti lineage tracing in mice found single clones giving rise to proximal tubule, parietal cells, and podocytes within one nephron. The lesson: a fate set during early patterning can be revised later in development. This plasticity is not sloppiness. It appears to be a built-in way for the tissue to reach the correct final architecture — a principle that likely reaches well beyond the kidney. Spatial transcriptomics demonstrates fetal-specific widespread PT molecular expression patterns within the renal corpuscle. A model diagram showing that a committed proximal tubule cell can still switch onto the parietal cell path, adding a late correction step to the classic linear model.

1/ 🚨 Out today in @ScienceAdvances , and I could not be more excited. ELF3: a GWAS gene that reprograms injured kidney tubules. science.org/doi/epdf/10.1126… GWAS have handed nephrology more than 1000 kidney function loci. Here we nail one down: ELF3 is the effector gene at an eGFR GWAS locus. When we delete it in a sick kidney, injured proximal tubule cells turn back toward a normal epithelial state. 🧵