A canine research venture. First study: follistatin gene therapy for arthritis and healthspan. Launching on BioXyz. Join us on Discord: https://teapawt.net/t.co/HhaUgHfyJY
The Dog Park
Joined March 2025
- Tweets220
- Following201
- Followers821
- Likes2.9K
Dog Years DAO retweeted
did a dog write this
A surprising new study finds that people who sleep near their dogs don’t experience disrupted sleep. If anything, the University of Toronto researchers discovered, we humans are the ones disturbing our dogs’ sleep. nbcnews.com/health/health-ne…
What is the 'biotech valley of death', and how can our canine companions help us bring more treatments to market? Our founder recently spoke on this podcast, covering that topic and his path towards gene therapy for canines. youtube.com/watch?v=broWTsqJ…
Dog Years DAO retweeted
Maybe we've fixed our focus on the wrong animals when it comes to Aging research
Mice are incredibly useful for biomedical research.
But aging isn't a single pathway, and mice might not be the perfect fit to bring the breakthrough that aging research requires...here's why 👇
Dog Years DAO retweeted
BPC-157 is finally getting a proper human trial.
We'll have answers early 2028.
About time.
The University of Arkansas just launched the 1st U.S. based injectable BPC-157 Randomized Controlled Trial for tissue healing.
They’re studying post-rotator cuff surgery healing through objective measures like strength testing, MRI, and range of motion. Also patient reported questionnaires on recovery (PROMs).
This is what the science community and physicians needed.
Enrollment starts Early 2027.
First data likely to be seen Early 2028.
I will keep you updated.
clinicaltrials.gov/study/NCT…
#bpc #bpc157 #peptide #peptides #science #research
Interesting study; a not great sign for the longevity projects that hope to replace the body piece by pieces.
Wow, this is a pretty striking result for my Strong Epigenetic Theory of Aging: transplant an old heart into a young animal and the heart is rejuvenated. But transplant a young heart into an old animal, and it quickly ages to match the recipient.
This shows that biological age is not simply something an organ accumulates locally as irreversible “wear and tear.” Instead, to a large degree, it is a state imposed by the organism-wide environment.
The authors saw bidirectional remodeling of both DNA methylation and gene expression, with old hearts in young hosts moving toward youthful programs and young hearts in old hosts moving toward aged ones.
That is exactly what you’d expect to see if aging is a regulated, system-level state where the epigenome is acting as the writable control layer that tissues continuously adjust to the organism’s age.
For decades, longevity research has leaned on one test subject: the lab mouse. The results in rodents are often stunning... and then ~80% of them fail to translate to humans.
Which raises an uncomfortable question: have we been studying the wrong species this whole time? 🧵
So what shares our genetic diversity and our environment? The dog on your couch.
Dogs age in real households, not labs. Their aging likely overlaps with ours far more than a mouse's ever could.
But you can't just cage a million dogs - that's the same trap, bigger. The post's answer flips it: bring research into homes. A living, open aging study where owners earn tokens, researchers get real-world data, and breakthroughs cross borders instantly.
The secrets of longevity shouldn't be locked in a lab:
dogyears.bio/post/breaking-t…
Dog Years DAO retweeted
Owning a dog was linked to 40 percent lower odds of developing disabling dementia over four years, in a study of 11,194 older adults in Tokyo. Cat owners showed no difference at all.
Residents of Ota City, Tokyo, aged 65 to 84, filled out a detailed health survey in 2016. Researchers from the Tokyo Metropolitan Institute of Gerontology then followed them for about four years using Japan's long-term care records, where doctors rate whether someone's dementia is severe enough to need care. The study appeared in Preventive Medicine Reports in 2023.
Only 8.6 percent of these older adults owned a dog. Dog owners can differ from everyone else in health, income, and lifestyle, so the team statistically balanced the groups on physical, social, and psychological traits before comparing them.
Current dog owners had 40 percent lower odds of disabling dementia than people who had never owned a dog or no longer did. Cat owners matched non-owners. Dog owners who also exercised regularly had 63 percent lower odds compared with non-owners who didn't exercise, and dog owners who weren't socially isolated had 59 percent lower odds than isolated non-owners.
Walking a dog counts as moderate exercise, and the researchers point to both the physical activity and the social contact that come with daily dog care. Cats rarely need a walk around the neighborhood.
Healthier people may also be more able to keep a dog, and a study like this can't fully separate the two. Across 11,194 older adults, the lowest dementia risk showed up in dog owners who were also active and socially connected. pubmed.ncbi.nlm.nih.gov/3786…
Dog Years / Charles Cormier Podcast teapawt.net/i/broadcasts/1MJgNbENA…
teapawt.net/DogYearsDAO/status/210… I added a bit about 'race science' to this thread/ article about Goodhart's Law.
Psychology's replication crisis nuked half the field's famous findings.
Longevity clinics sell "biological age" reversal.
Race scientists post national IQ maps.
Different worlds, same failure mode: a number stopped being evidence and became the argument. 🧵 1/12
The alternative isn't abandoning measurement.
Rather, keeping numbers subordinate to purpose.
Can the dog still run? Is it free from pain? Does it want to play again?
Those are measures that are meaningful; biology expressed through behavior. 11/12
This is what Dog Years DAO is built around: community-owned research, real-world evidence, transparent data, and endpoints that answer whether life actually got better.
Full article: dogyears.bio/post/goodhart 12/12
