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EFFECT Trial (@EffectTrial) profile picture

EFFECT Trial

@EffectTrial

EFFECT Trial: Efficacy of Flucytosine & Fluconazole as Early Cryptococcal Treatment. Phase 3 RCT at 13 sites in South Africa, Tanzania, Vietnam. Funded @The_MRC

isrctn.com/ISRCTN30579828
Joined February 2022
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Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)Photo by EFFECT Trial (@EffectTrial)
Great week in S Africa @MSF_southafrica discussing all things cryptococcosis, histoplasmosis & advanced HIV disease. Now @WitsUniversity where I gave a lecture on interdisciplinary research within @IMPRINT_NIHRGHR & met @neleshg & our @EffectTrial social science team @NIHRglobal – at Johannesburg, South Africa
Image from David Lawrence (@drdavidlawrence)
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Thrilled that today @JNJarvis76 and I were able to represent the huge and wonderful @ambitioncm2020 team and receive the @EACSociety European Hector Research Award for best clinical/epidemiological paper in HIV in the last two years. Dedicated to all participants #EACS2023 – at Warsaw, Poland
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Is fluconazole enough for cryptococcal antigenaemia? The @EffectTrial is exploring the impact of flucytosine plus fluconazole in South Africa and Tanzania. Thrilled to be part of this wonderful team! – at Plumpton, England
School of Health & Medical Sciences (@CityStG_Health) profile pictureSchool of Health & Medical Sciences@CityStG_Health19 Jul 2023
St George’s researchers are leading an international trial which aims to improve treatment to prevent a type of meningitis that attacks the brain in people with advanced HIV, thanks to £4.5m funding from @The_MRC. Learn more about the @EffectTrial: sgul.ac.uk/news/4.5m-interna…
Dr Síle Molloy from SGUL and Professor Nelesh Govender from the University of the Witwatersrand.

ALT Dr Síle Molloy from SGUL and Professor Nelesh Govender from the University of the Witwatersrand.

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St George’s researchers are leading an international trial which aims to improve treatment to prevent a type of meningitis that attacks the brain in people with advanced HIV, thanks to £4.5m funding from @The_MRC. Learn more about the @EffectTrial: sgul.ac.uk/news/4.5m-interna…
Dr Síle Molloy from SGUL and Professor Nelesh Govender from the University of the Witwatersrand.

ALT Dr Síle Molloy from SGUL and Professor Nelesh Govender from the University of the Witwatersrand.

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Incredible week at the #ICCC in Kampala. Glastonbury for #cryptococcus! Great to connect with amazing colleagues, make new friends and discuss future collaborations. Phenomenal organisation by the team! – at Kampala, Uganda
Image from David Lawrence (@drdavidlawrence)
Image from David Lawrence (@drdavidlawrence)
Image from David Lawrence (@drdavidlawrence)
Image from David Lawrence (@drdavidlawrence)
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EFFECT Trial retweeted
Bahati (@BahatiHauleTz) profile picture
Bahati@BahatiHauleTz14 Dec 2022
I am so excited for this trial taking place in Tanzania for a probable better treatment for PLHIV with Crypto….
EFFECT Trial (@EffectTrial) profile pictureEFFECT Trial@EffectTrial17 Nov 2022
We are so pleased today to be opening our next 3 @NIMR_Tanzania sites in Amana, Temeke and Mwananymala, Dar es Salaam, Tanzania. Our 8 South African sites are open and we have enrolled 15 participants to date. Looking forward to the next 585!
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Super excited to be working on the #HealthEconomics aspect of this project. #EEACTs #EconomicEvaluation #Modelling #HTA #clinicaltrials
EFFECT Trial (@EffectTrial) profile pictureEFFECT Trial@EffectTrial6 Dec 2022
Fantastic to have experts from @uctphm Health Economics Division collaborating in the @IMPRINT_NIHRGHR group and assisting on our @EffectTrial health economics substudy with @ucl and @LSTMnews
Image from EFFECT Trial (@EffectTrial)
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Graeme Meintjes (@graemein) profile picture
Graeme Meintjes@graemein5 Dec 2022
Replying to @IMPRINT_NIHRGHR
@IMPRINT_NIHRGHR investigators meeting at UCT. PIs Nelesh Govender and Joe Jarvis. Tackling fungal infections in PLHIV … improving implementation and advancing science
Image from Graeme Meintjes (@graemein)
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Thousands of people with #HIV die each year from fungal infections, including #cryptococcal meningitis, because medicines are not available. We're partnering with @IMPRINT_NIHRGHR for better treatments & #access2meds. ➡️ bit.ly/3VYY3o7 #EndHIVCryptoDeaths #WorldAIDSDay
Image from Drugs for Neglected Diseases initiative (@DNDi)
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Replying to @UNAIDS
@UNAIDS target to ⬇️AIDS deaths <250,000 by 2025 will NOT be met...unless we step up our game Our @NIHRglobal Global Health Research Group will seek innovative solutions through research, implementation and community engagement to reduce AIDS deaths caused by fungal infections
Image from IMPRINT Fungal HIV Global Research Grp (@IMPRINT_NIHRGHR)
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New publication alert! Economic analysis of @ambitioncm2020 published today in @LancetGH demonstrating the cost and cost-effectiveness of the single, high-dose liposomal amphotericin regimen for cryptococcal meningitis in five countries in E and S Africa thelancet.com/journals/langl…
Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated crypto...

Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated crypto...

The AmBisome regimen was cost-effective at a low incremental cost-effectiveness ratio. The regimen might be even less costly and potentially cost-saving in real-world implementation given the lower...

thelancet.com
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Our group will collaborate with @DNDi to evaluate sustained-release flucytosine for twice-daily dosing in the later stages of the @EffectTrial if all goes to plan in Phase 1/2 DNDi studies
Drugs for Neglected Diseases initiative (@DNDi) profile pictureDrugs for Neglected Diseases initiative@DNDi5 Oct 2022
Today is #WorldMeningitisDay. Together with partners, we’re developing an improved formulation of a life-saving treatment for cryptococcal #meningitis that would halve the number of times people need to take the medication every day. Read more ➡️ bit.ly/2VjmOOk
Image from Drugs for Neglected Diseases initiative (@DNDi)
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Free online course on #AntimicrobialResistance and #AntimicrobialStewardship for all South African Health care workers knowledgehub.org.za/course/a… Time to optimise the use of antibiotics in 🇿🇦 @HealthZA @Sandilebuthele @DALRRDgov_ZA @Mediclinic @LifeHealthcare_ @Netcare_Limited
Image from Marc Mendelson (@SouthAfricanASP)
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Replying to @docdavestead
I visited Gqeberha this week for an @EffectTrial site initiation visit. Real challenges in health system but also islands of excellence, especially in ID! Kept going by dedicated and excellent people I'm looking forward to your interview, @docdavestead
Dr John Black, Ms Vanessa Pearce, Dr Shareef Abrahams at NHLS PE lab

ALT Dr John Black, Ms Vanessa Pearce, Dr Shareef Abrahams at NHLS PE lab

Image from Nelesh Govender (also @neleshg.bsky.social) (@neleshg)
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Using the @nicd_sa GERMS-SA surveillance platform, we confirmed the effectiveness of flucytosine-containing regimens in halving HIV cryptococcal meningitis mortality in routine care at 19 🇿🇦 hospitals Free full-text link here: authors.elsevier.com/c/1fHh3…
Image from Nelesh Govender (also @neleshg.bsky.social) (@neleshg)
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Great to hear from @Molloy_Sile that the Tanzania Medicines and Medical Devices Authority has approved 5FC for cryptococcal meningitis. This will strengthen the case for a sustained supply in routine care, beyond the @UNITAID CHAI programme. @EffectTrial
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"When we think about research integrity we often think about individual researchers and forget that individual researchers occur within a large and complex research ecosystem" - @ntobekon @UCT_Research #WCRI2022 news.uct.ac.za/article/-2022…
Transparency, collaboration underpin clinical and biomedical research integrity

Transparency, collaboration underpin clinical and biomedical research integrity

UCT Professor Ntobeko Ntusi delivered a plenary session at the 7th World Conference on Research Integrity in the Cape Town.

news.uct.ac.za
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And its nearly time to say our farewells. Delegates settle in for the closing plenary for #WCRI2022. It's been an insightful and inspiring conference
Image from World Conf Research Integrity (@WCRIFoundation)
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EFFECT Trial retweeted
CAMARADES (@CAMARADES_) profile picture
CAMARADES@CAMARADES_1 Jun 2022
Delighted to be representing CAMARADES at the #WCRI2022 in Cape Town where we have been discussing how to increase the robustness of preclinical data and research improvement. My slides are available here: osf.io/4qdav/
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I spoke to Vindana Chibabhai in an upcoming episode of her @microbemail podcast - 7 June 2022, 3pm We talked about Cryptococcus, CrAg screening as a public health tool as well as recent innovations in diagnosis and antifungal treatment for meningitis & antigenaemia
Image from Nelesh Govender (also @neleshg.bsky.social) (@neleshg)
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