Han Yang (@HanYang_Henry) header
Han Yang (@HanYang_Henry) profile picture

Han Yang

@HanYang_Henry

Postdoc at @UCSF with @YinShenlab. Passionate about developing innovative tools to address genetic questions related to diseases.

Joined June 2022
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  • Following195
  • Followers45
We’re unwrapping a new method today @MSKCancerCenter! Led by @SydneyBlattman, @NabihMaslah, @AustinAVarela, Ronan Chaligne and @dana_peer, plus colleagues at @10xGenomics, we’re delighted to share Genotyping In Fixed Transcriptomes (GIFT): biorxiv.org/content/10.64898… 1/n
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Han Yang retweeted
Zihan Xu (@xu_zxu) profile picture
Zihan Xu@xu_zxu6 Oct 2025
Thanks for including our method in this review! – at Pittsburgh, PA
Nature Reviews Molecular Cell Biology (@NatRevMCB) profile pictureNature Reviews Molecular Cell Biology@NatRevMCB6 Oct 2025
New Online! Elucidating the coordination of RNA processing using short-read and long-read RNA-sequencing methods bit.ly/42udQkp
Image from Nature Reviews Molecular Cell Biology (@NatRevMCB)
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An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted Perturb-seq biorxiv.org/content/10.1101/… #biorxiv_genomic
An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted...

An unbiased survey of distal element-gene regulatory interactions with direct-capture targeted...

A major challenge in human genetics is to identify all distal regulatory elements and determine their effects on target gene expression in a given cell type. To this end, large-scale CRISPR screens...

biorxiv.org
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Evolution of splicing model architectures go.nature.com/3I7QBoS Figure from our recent Review: From computational models of the splicing code to regulatory mechanisms and therapeutic implications (free to read here: rdcu.be/dVNV4)
Image from Nature Reviews Genetics (@NatureRevGenet)
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Excited to share #AlphaGenome, a start of our AlphaGenome named journey to decipher the regulatory genome! The model matches or exceeds top-performing external models on 24 out of 26 variant evaluations, across a wide range of biological modalities.1/6
Image from Jun Cheng (@s6juncheng)
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Scalable generation and functional classification of genetic variants in inborn errors of immunity to accelerate clinical diagnosis and treatment: Cell cell.com/cell/fulltext/S0092… Thrilled to see this transformative paper published- and so sad that its NIH funds are frozen!
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A machine learning model for prime editing efficiency prediction takes into account chromatin context go.nature.com/3VQNmq9 rdcu.be/em3Yi
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Excited to be part of this amazing HAR project! 🎉 Congrats to the whole team! 🚀
Xiekui Cui (@MarkTransposon) profile pictureXiekui Cui@MarkTransposon26 Feb 2025
How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s41586-0…. 1/12
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How did humans develop unique traits despite sharing nearly identical genomes with other primates like chimpanzees? Together with Han Yang (@HanYang_Henry), our new study on human accelerated regions (HARs) sheds light on this question @ nature.com/articles/s41586-0…. 1/12
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Now Online: Modelling human brain development and disease with organoids go.nature.com/41uwWXO
Image from Nature Reviews Molecular Cell Biology (@NatRevMCB)
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Understanding the molecular diversity of synapses — a Review by Marc van Oostrum & Erin M. Schuman go.nature.com/3ZKmRVx @Marc_vOo @erin_schuman
Image from Nature Rev Neurosci (@NatRevNeurosci)
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Several excellent Human Cell Atlas papers in @nature this week. Highlights for me: 1. The integrated transcriptomic cell atlas of human neural #organoids, @zhisong_he @TreutleinLab @fabian_theis @GrayCampLab @Sergiu_P_Pasca @GiorgiaQuadrato & colleagues nature.com/articles/s41586-0…
An integrated transcriptomic cell atlas of human neural organoids

An integrated transcriptomic cell atlas of human neural organoids

Nature - A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid...

nature.com
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Flexible differential expression analyses have always been neat in CZ #CellxGene. Now they’re next level! Quickly perform DE analysis across our entire data corpus. For ex: leveraging >125 relevant datasets to compare astrocytes with/without Alzheimer’s📷 bit.ly/4eDt9uU

Cellxgene Data Portal

Find, download, and visually explore curated and standardized single cell datasets.

cellxgene.cziscience.com
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Excited to share my lastPhD publication! We discovered non-inherited mutational patterns in schizophrenia occurring before birth. Huge collaborative effort w/ @seplyarskiy @jones_attila science.org/doi/10.1126/scie…
Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes

Somatic mosaicism in schizophrenia brains reveals prenatal mutational processes

Germline mutations modulate the risk of developing schizophrenia (SCZ). Much less is known about the role of mosaic somatic mutations in the context of SCZ. Deep (239×) whole-genome sequencing (WGS)...

science.org
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Spatial omics technology is transforming our understanding of in situ RNA biology. We are grateful for the opportunity to publish this review in @MolecularCell. We hope this will be a useful resource for the community. @HailingShi @nemo08061 @WangXiaoLab
Molecular Cell (@MolecularCell) profile pictureMolecular Cell@MolecularCell12 Sep 2024
Online Now: Spatial omics advances for in situ RNA biology dlvr.it/TD8Y9t
Image from Molecular Cell (@MolecularCell)
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Much of the impact of alternative splicing is mediated by nonsense-mediated decay-induced changes in gene expression rather than diversification of the proteome @NatureGenet @yang_i_li nature.com/articles/s41588-0…
Image from Waggoner Lab (@LabWaggoner)
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Have you ever wondered about how the genomic position of regulatory elements impact their functional output? Check out our latest pre-print from the @bvanssteensellab. biorxiv.org/content/10.1101/…
Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances. The importance of this positioning is poorly understood. By relocating promoter-reporter constructs into >1,000 alternative...

biorxiv.org
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Excited to share my PhD work in the lab of @larsplus @CRGenomica. We screened the activity of synthetic enhancers throughout myeloid differentiation. Combinations of activating TFs frequently neutralized each other or gained repression twtr.to/wiWIZ (1/n)
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Our commentary (with Alex Sasse @LXandR_ and Maria Chikina @ChikinaLab ) on past and future of sequence-to-function deep genomics models is online @naturemethods : nature.com/articles/s41592-0… Along with many thoughtful Comment Articles online today: nature.com/nmeth/articles?ty…
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I'm excited to share our latest work, out today in @Nature Grateful to work with amazing co-leads @MathysHansruedi @carles_boix , and always grateful for @DrLiHueiTsai 's mentorship! nature.com/articles/s41586-0…
Single-cell multiregion dissection of Alzheimer’s disease

Single-cell multiregion dissection of Alzheimer’s disease

Nature - A regional atlas of the ageing human brain—spanning six distinct anatomical regions from individuals with and without Alzheimer’s dementia—provides insights into cellular...

nature.com
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