Thomas Laval (@Laval_T) profile picture

Thomas Laval

@Laval_T

Postdoc @HeartInstitute in @MireilleOuimet lab | Lipid metabolism, Macrophages & Autophagy | PhD @Demangel_Lab studying Fatty Acids and Tuberculosis

 Ottawa, Canada
Joined December 2021
  • Tweets59
  • Following250
  • Followers135
Thomas Laval retweeted
Jeeyun Chung (@JeeyunC) profile picture
Jeeyun Chung@JeeyunCJun 29
What do lipid droplets do in neurons? Thrilled to share the 🌟1st preprint from my lab, led by Eleni Katafygiotou, showing activity-dependent formation of neuronal LDs in vitro and in vivo, and the impact of LD modulation on neuronal function and behavior. biorxiv.org/content/10.64898…
Activity-dependent lipid droplet biogenesis and turnover regulate synaptic integrity

Activity-dependent lipid droplet biogenesis and turnover regulate synaptic integrity

Lipid droplets (LDs) are conserved organelles that buffer lipid storage and stress, yet their dynamics and functions in neurons remain largely unknown. Here, we report activity-dependent dynamics of...

biorxiv.org
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Preprint alert! A role for the ESCRT protein HRS in hepatocyte lipophagy. Congratulations authors @mwillzzz411, @ankit_shroff, and Bridget Crossman (@UWMadison )! biorxiv.org/content/10.1101/… @UNMC_Biochem @unmc
The ESCRT-0 protein HRS regulates hepatocellular lipid droplet catabolism

The ESCRT-0 protein HRS regulates hepatocellular lipid droplet catabolism

Lipid droplets (LDs) are dynamic organelles that regulate lipid storage and metabolism pathways central to metabolic liver disease. LD turnover occurs in part through lysosomal catabolism (i.e....

biorxiv.org
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Long-chain fatty acids can be carbon sources for pathogens but are also potent antimicrobials. In our latest work, we explored the question of how Mycobacterium tuberculosis avoids getting killed by a preferred carbon source. biorxiv.org/content/10.1101/…
The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein...

The Mycobacterium tuberculosis long-chain fatty acid resistome reveals the universal stress protein...

The human pathogen Mycobacterium tuberculosis (Mtb) thrives in lipid-rich microenvironments. Long-chain fatty acids (LCFA) are some of the most abundant lipids encountered by Mtb during infection....

biorxiv.org
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Halmos et al show that the deficiency of cholesterol transporters #Abca1 & #Abcg1 in #SMCs enhances #vasoconstriction & urinary #bladder distension but does not affect lesion area in #atherosclerosis. Learn more at ahajrnls.org/3FaMG9b @SluimerJudithHelle @hfj22
Image from Circulation Research (@CircRes)
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Thomas Laval retweeted
Canaan Lab (@canaanlab) profile picture
Canaan Lab@canaanlab25 Feb 2025
Happy to share our last paper published in m bio. A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio journals.asm.org/doi/10.1128…
A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio

A proteomic and functional view of intrabacterial lipid inclusion biogenesis in mycobacteria | mBio

This study sheds light into the complex process of intracellular lipid accumulation and storage in the survival and persistence of pathogenic mycobacteria, which is of clinical relevance. By identi...

journals.asm.org
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A HUGE Cuervo Lab effort exploring sex and age differences of CMA activity was published in @NatureAging today! Check out the publication nature.com/articles/s43587-0… and the @EinsteinMed press release montefioreeinstein.org/news/… !!

Sex-specific and cell-type-specific changes in chaperone-mediated autophagy across tissues during...

Nature Aging - Using single-cell imaging of a fluorescent chaperone-mediated autophagy (CMA) reporter and RNA sequencing data, the authors present a resource on basal CMA activity across organs,...

nature.com
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Thomas Laval retweeted
Alex (@AlexandreGouzy) profile picture
Alex@AlexandreGouzy3 Dec 2024
Happy to share my first ever (co)last author paper 🥳 reporting on how Mtb adapts its carbon diet under acid stress. A big thank you to my partners in crime @saehrt and @healycl without who this would not have been possible 😘 Find us on @bluesky now journals.asm.org/doi/10.1128…
An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utiliza...

An exacerbated phosphate starvation response triggers Mycobacterium tuberculosis glycerol utiliza...

Despite the availability of antibiotic treatment, M. tuberculosis (Mtb), the causative agent of tuberculosis (TB), remains a major infectious disease killer worldwide. A better understanding of the...

journals.asm.org
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Thomas Laval retweeted
Ivan Đikić (@iDikic2) profile picture
Ivan Đikić@iDikic231 Oct 2024
How #autophagy influences the regulation of MHC-I class receptors and regulates #immune evasion of #cancer? A new role for an autophagy receptor IRGQ in this process with a clinical relevance for the development of liver carcinoma in humans and mice 😊😀 sciencedirect.com/science/ar…
Image from Ivan Đikić (@iDikic2)
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rdcu.be/dMdQ9   Excited and proud to see the final version of our manuscript out @NatureComms, describing a new lipid droplet reporter mouse, which allows staining-free fluorescent visualization of #LipidDroplets!! Check out how numerous they are in the brain!
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Our latest work on #liver lipophagy and Rab5 is published in Hepatology Communications today! #alcohol @AASLDtweets journals.lww.com/hepcomm/ful… Major findings in thread below:
Ethanol disrupts hepatocellular lipophagy by... : Hepatology Communications

Ethanol disrupts hepatocellular lipophagy by... : Hepatology Communications

Background:Previous reports suggest that lipid droplets (LDs) in the hepatocyte can be catabolized by a direct engulfment from nearby endolysosomes...

journals.lww.com
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🫧 Special Issue! #LipidDroplets in Health and Disease 👩‍🔬 Guest editors: @MariaBohnert & @BiancaSchrul ➡️ bit.ly/44SET8Z 16 reviews highlight new discoveries in the lipid droplet lifecycle and insights into diseases related to lipid storage. @wwu_muenster @Saar_Uni
Image from FEBS Letters (@FEBS_Letters)
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Thomas Laval retweeted
CAPS-ACPP (@CAPSACPP) profile picture
CAPS-ACPP@CAPSACPP17 Apr 2024
@CAPSACPP is thrilled to see new investments in Canadian postdocs in #Budget2024! $825M to support future research talent. $1.8B to support grants. Federal postdoctoral fellowships will be increasing from $40k to $70k! An amazing investment in our research talent 🎉
Image from CAPS-ACPP (@CAPSACPP)
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#GradStudent scholarships and #Postdoc fellowships got a raise today for the first time in 21 years🙌 Immensely grateful to all those who have been pushing for this. It truly takes a village! Still processing and will have more thoughts soon! But overall this👇 is great news!
Image from Sarah Laframboise (@SLaframboise14)
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Following a rigorous international recruitment process, the University of Ottawa Heart Institute has named Dr. Katey Rayner as its next chief scientific officer and vice-president of research. Congratulations! ow.ly/vue050Rcg9g @KateyRayner #ottnews
Image from Heart Institute (@HeartInstitute)
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Excited to announce our work on Dietary #protein, #leucine, #macrophage, #mtor, and #CVD (#atherosclerosis) published in @NatMetabolism. First authors @XiangyuZ0321, Dr. Divya kapoor, & collaborators did a fantastic translational and mechanistic study. nature.com/articles/s42255-0…
Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and...

Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and...

Nature Metabolism - Zhang et al. use human studies and mechanistic work in mouse models to describe how leucine serves as the key amino acid derived from dietary protein to drive deleterious...

nature.com
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Finally out there - Recognition of yeast β-glucan particles triggers immunometabolic signa... sciencedirect.com/science/ar… Tweetorial Follows (1/12)
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I am thrilled to share our work describing the role of Aster proteins in intestinal physiology! Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake | Science science.org/doi/full/10.1126…
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Thomas Laval retweeted
David Sancho (@SanchoLab) profile picture
David Sancho@SanchoLab26 Oct 2023
🚨🚨 POSTDOC ADVERT!!! We offer a postdoc position focused on metabolism of macrophages and dendritic cells and their targeting for immunotherapy of cardiovascular diseases. I will be very grateful if you can distribute the advert🙏 cnic.es/en/investigacion/imm…
Image from David Sancho (@SanchoLab)
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New paper alert! The PhD work of @LeahSusser is now online. Leah found that mitochondrial dynamics (fission + fusion) are critical for resolution responses in macrophages. 1/ tandfonline.com/doi/full/10.…
Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone...

Mitochondrial Fragmentation Promotes Inflammation Resolution Responses in Macrophages via Histone...

During the inflammatory response, macrophage phenotypes can be broadly classified as pro-inflammatory/classically activated “M1”, or pro-resolving/alternatively “M2” macrophages. Although the class...

tandfonline.com
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Check out @ia_windham’s review on the Cell Biology of APOE in the Brain. Such a fascinating protein with so many open questions! @ApoEdscvr nam12.safelinks.protection.o…
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