@LeuschnerLab

Heisenberg Professorship for Immunocardiology @Uniklinik_hd

 Heidelberg, Deutschland
Joined May 2024
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cool paper alert 👇 biorxiv.org/content/10.64898…

Tricuspid valve regurgitation accelerates heart failure via a cardio-intestinal innate immune...

Activation of the immune system impacts the progression of heart failure (HF), but the underlying mechanisms remain incompletely understood. Here, we identify a cardio-intestinal innate immune axis...

biorxiv.org
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Using the first mouse model of tricuspid valve regurgitation, we identify a cardio-intestinal innate immune circuit in which chronic venous congestion reprograms monocytes into IL-6-producing drivers of heart failure. doi.org/10.64898/2026.07.07.…
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Leuschner Lab retweeted
EdT@thorplab17 Apr 2025
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In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion. Check out the full study here: doi.org/10.1161/CIRCRESAHA.1… Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF

High-Throughput Echocardiography-Guided Induction of Myocardial Ischemia/Reperfusion in Mice |...

BACKGROUND: Mouse models of myocardial ischemia with subsequent heart failure are common approaches to examine heart failure pathology and possible treatment strategies. We sought to establish a...

ahajournals.org
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What do Angptl4 and collagen IV have to do with fibrosis in HFpEF?🫀 Proud to have found some answers!🔬 Thanks to my co-first @jan_lanzer, all authors and our supervisor team for excellent support @LeuschnerLab @JulioSaezRod 👌🏻 link.springer.com/article/10…
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Molecular fibroblast activation patterns in heart failure. link.springer.com/article/10…
Integrated atlas of cardiac fibroblasts from different disease models. UMAP embeddings, showing the integrated fibroblast atlas colored by cell clusters, i.e. the integrated fibroblast states (IFS). Labels indicate possible fibroblast differentiations based on functional characterization.

ALT Integrated atlas of cardiac fibroblasts from different disease models. UMAP embeddings, showing the integrated fibroblast atlas colored by cell clusters, i.e. the integrated fibroblast states (IFS). Labels indicate possible fibroblast differentiations based on functional characterization.

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Check out our paper just published in Circulation ➡️ Translation controls inflammation after myocardial infarction doi.org/10.1161/CIRCULATIONA… This work was a huge collaborative effort over many years. @dzhk_germany @DGK_org @VolkersMirko Key findings + paper summary below 🧵⬇️⬇️⬇️
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Bronwyn@BronwynBerkeley19 Jun 2024
Read my Tools of the Trade article, published in @NatRevCardiol, highlighting my experience with and the method of ultrasound guided induction of myocardial infarction: rdcu.be/dLgU3 Thanks to @FloSicklinger & F. Leuschner for developing such an innovative method.
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Couldn't attend the #Immuno-#Cardiology Symposium @FondationLeducq @jacksonlab? No problem-> read the report 'Linking immune modulation to cardiac fibrosis' here 👉 rdcu.be/dIUBP #fibrosis #cardioimmunology
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Denis@DenisSchapiro22 May 2024
I am very excited to share our lab's first preprint @uniklinik_hd together with the @LeuschnerLab. This study was led by @FloWuenne and @FloSicklinger. biorxiv.org/cgi/content/shor…
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