Professor/Chair of the Dept of Biochemistry and Molecular Pharmacology at BCM. Using structural and molecular biology to answer the big questions since 1991.
Houston, TX
Joined January 2022
- Tweets56
- Following107
- Followers141
- Likes170
Tim Palzkill Lab retweeted
50,000+ enzyme variants tested. A new catalytic mechanism. A highly interconnected, substrate-dependent network of amino acid interactions discovered. Blood, sweat, tears (mine). This story has it all, folks: pnas.org/doi/10.1073/pnas.23…
@PNASNews @PalzkillLabBCM
Tim Palzkill Lab retweeted
Some work by my labmates @PalzkillLabBCM that I helped with during my PhD went live over the holidays! We used DNA-encoded libraries to find highly potent inhibitors of two prominent carbapenemases, NDM-1 and OXA-48.
pubs.acs.org/doi/abs/10.1021…
Tim Palzkill Lab retweeted
So happy to share this story and that I was able to play a small part in it! We discovered and validated highly potent small molecule inhibitors of the SARS-CoV-2 main protease, including variants that show resistance to current antiviral treatments.
A new type of SARS-CoV-2 Mpro inhibitor is discovered by DNA-encoded chemical library screening, reported by @bcmhouston & @DamianYoung29 & @Srini_Chamakuri & @PalzkillLabBCM nature.com/articles/s42004-0…
Tim Palzkill Lab retweeted
A new type of SARS-CoV-2 Mpro inhibitor is discovered by DNA-encoded chemical library screening, reported by @bcmhouston & @DamianYoung29 & @Srini_Chamakuri & @PalzkillLabBCM nature.com/articles/s42004-0…
Tim Palzkill Lab retweeted
Beautiful simulation work by @fiona_chembot shows structural & dynamical mechanisms of transmissible Paxlovid-resistant SARS-CoV-2 variants w/ @HarrisLabUTHSA @PalzkillLabBCM
science.org/doi/10.1126/scia…
Tim Palzkill Lab retweeted
Excited to start recruiting postdocs + research assistants to my lab @sangerinstitute
Massive mutagenesis to make biophysics + human genetics predictive? allostery, affinity, stability, splicing, receptors, TFs, cancer. pls RT
tinyurl.com/bmb9vv5s
tinyurl.com/49f3ubc3
Tim Palzkill Lab retweeted
I am excited to announce that an NIH-funded postdoc position has just opened up. The position is in the area of quantitative superresolution imaging and cell biology. Reposting / Retweeting much appreciated. #superresolution #bioimaging #postdocposition #ohsu #CellBiology
Tim Palzkill Lab retweeted
I’m so glad I got to share my science at the #3MT finals this week! Take three minutes to give it a listen, if you’re curious what protein engineering has to do with getting dressed in the morning 🧐
youtu.be/v1EyJK6n_x4
Tim Palzkill Lab retweeted
Are you or someone you know looking for a postdoctoral position? We're hiring! Come join our new team at Baylor College of Medicine in Houston, where we're working to evolve antibiotics and the enzymes that make them!
nature.com/naturecareers/job…
Tim Palzkill Lab retweeted
#PostdocPosition alert! How do commensal bacteria and viruses influence enteric viral infections? Interested in answering that question using clinical data and intestinal #organoids? Join our #collaborative research group with @EstesLab_BCM @bcmhouston
jobs.bcm.edu/job/Houston-Pos…
Tim Palzkill Lab retweeted
We are excited to announce that we will be cohosting the “Celebrating Women in Science” event on April 27, 2022. Registration is required.
dhvi.duke.edu/celebrating-wo…
#womeninSTEM
@thedhvi @dukehealth @dukestudents @dukegradschool @dukeuniversity @dukeghi @dukealumni
Tim Palzkill Lab retweeted
Particular molecular #hotspots influence protein-protein interactions. Lessons from #βLactamase (BL) and BL-inhibitory #protein @PalzkillLabBCM @BiochemistryACS #antibiotics blogs.bcm.edu/2022/02/01/fro… via @bcmhouston
Tim Palzkill Lab retweeted
This new review from Boyang Zhao in the Prasad lab at BCM discusses how understanding structural features of the #norovirus #protease can help us develop broad-spectrum norovirus antivirals
@sash_ramani @BCMFromtheLabs
mdpi.com/1312344
Tim Palzkill Lab retweeted
From the Labs is calling for #research #image and #video #submissions! @BCMGradSchool @BCM_GradDiverse @Evelin_Y_ blogs.bcm.edu/2022/01/20/fro… via @bcmhouston
Tim Palzkill Lab retweeted
The Raghavan Lab @bmentamu is looking for a postdoctoral researcher, funded by @CPRITTexas - DM if you're interested in creating cancer micro-tissue models for new chemotherapies and see us contributing to your career development! Please RT! @BlackInBME @LatinXinBME
ALT Picture describing the postdoc position in the Raghavan Lab: the ability to participate in a core facility funded by CPRIT to create new high throughput cancer models; Relevant skills are cell culture, 3D tissue culture, flow cytometry and basic microscopy. A picture of a spheroid is shown in green, and the high throughput plate used to generate the spheroids. SITE Lab Logo is on the top left, and the department of biomedical engineering at TAMU logo is on top as well.
