@blue_ceil

Postdoc at the Leibniz Institute on Aging and Stanford, working on functional proteomics. #lysosomes #massspectrometry

Joined October 2018
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(1/3) Happy to share my first review together with @AOri_Lab on organelle dysfunction in aging and age-related diseases! Are you curious about the impact aging has on mitochondria and lysosomes? Then read this👉bit.ly/3IwB2lj
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Our Brain LysoAtlas is now out in Cell! We map the cell-type-specific protein composition of lysosomes and link SLC45A1 to neurological disease. Joint work by @LeibnizFLI, @Stanford_ChEMH & collaborators incl. @UniJena, led by @ali_ghoochani, @AOri_lab & @abu_remaileh.
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Many thanks to our colleagues and collaborators in Jena for their key contributions, including @nizzle_fe_shizz, @DomenicoFraia and the Kaether Lab. A true multi-institutional effort.
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Replying to @blue_ceil @LeibnizFLI @Stanford_ChEMH @UniJena @ali_ghoochani @AOri_lab @abu_remaileh
📄 Read the article: doi.org/10.1016/j.cell.2025.… 🌐 Explore the data via our interactive, browser-based Lysosomal Brain Protein Atlas: brainresilience.stanford.edu…
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🚨New Paper Alert🚨Explore our latest work on the Lysosomal BrainAtlas, now available on bioRxiv! This comprehensive resource maps lysosomal proteins in specific brain cell types and identifies SLC45A1 as a novel neuron-specific lysosomal sugar transporter doi.org/10.1101/2024.10.14.6…
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#CellBiology #Neuroscience #Lysosomes #BrainAtlas #Neurodegeneration #SLC45A1
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In this study co-led with @ali_ghoochani, we used LysoIP & high-res mass spectrometry to create the first lysosomal protein atlas across neurons, astrocytes, microglia & oligodendrocytes. A breakthrough for understanding cell-type-specific lysosomal functions in the brain!
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Here, we uncover the key roles of transporter SLC45A1 as a novel regulator of both lysosomal acidity and sugar export revealing previously unknown mechanisms of cell-type specific lysosomal functions, relevant to neurological diseases
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Congratulations on the outstanding publication regarding a potential therapeutic approach for Batten disease, a devastating childhood neurodegenerative disorder. Find out more👉cell.com/molecular-cell/full… @AOri_lab @abu_remaileh @blue_ceil @Stanford
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Herzlichen Glückwunsch💐Alessandro Ori @AOri_lab + Julia Heiby @blue_ceil haben für ihr Projekt “Targeting alterations of the lysosomal proteome in Batten disease” den Forschungspreis der @nclStiftung erhalten. Weitere Infos👉ncl-stiftung.de/aktuelles/ak… #battendisease #Kinderdemenz
Links: Dr. Alessandro Ori; rechts: Dr. Julia C. Heiby

ALT Links: Dr. Alessandro Ori; rechts: Dr. Julia C. Heiby

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Thanks to the @abu_remaileh lab and @Stanford_ChEMH for having me these past months and to the @DAAD_Germany and @LeibnizFLI for making this possible. It has been an outstanding experience! Bitter sweet to go back, I will miss the people and this place for sure.
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What a day to be at @Stanford celebrating with @CarolynBertozzi for winning the Nobel prize, together with her lab, the @Abu_Remaileh lab and Stanford ChEMH. Congrats!
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Julia Heiby retweeted
Tom Wilks@tom_wilks10 Aug 2022
Bohemian rhapsody for postdocs: Is this a real job? Or more like a PhD? Caught in short contracts No chance of stability Open your eyes Look up to PIs and see I'm just a postdoc I get no sympathy Because I'm easy come, easy go Stress is high Pay is low
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Happy to share our ProteasomeID method! 🎉
Alessandro Ori@AOri_lab10 Aug 2022
1/ Interested on protein degradation? Check out ProteasomeID, our new method to monitor proteasome interactions and substrates in cells and mouse models. 🧵👇 biorxiv.org/cgi/content/shor…
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📢 Excited to say we have two funded PhD studentships to join my team at the UK DRI in Cardiff. If you are enthusiastic to investigate the molecular mechanisms of Alzheimer's using iPSC models take a look! RT and share widely 📢 findaphd.com/phds/project/un… and findaphd.com/phds/project/un…
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Say hello to Leeloo and Chewie 🐈
Christian Franke@nizzle_fe_shizz5 Jun 2022
Mood #SleepySunday
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Julia Heiby retweeted
Lara Urban@LaraUrban422 May 2022
I am looking for students, PhDs & post-docs to work with me @HelmholtzMunich @PioneerCampus @helmholtz_ai @CompHealthMuc @helmholtz_en; please share with any curious researcher interested in #PlanetaryHealth #AI #PortableGenomics: bit.ly/3KCUAp4 & bit.ly/38I10Wq
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We have an opening for a PhD position starting this summer! Join an open and inclusive lab in a well funded institute. The project builds on exciting preliminary data, great collaborations, cutting edge model systems and technologies. Apply 👉 bit.ly/3KA8IAk by May 15th.
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Happy to see this out for the community, congrats to my colleague Sören 🎉 got localization microscopy data? like python? need analysis tools? - Check this 👉🏻 LOCAN: a python library for analyzing single-molecule localization microscopy data academic.oup.com/bioinformat…
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Our recent paper on #mRNA escape from endosomal recycling tubules @JCellBiol is featured by @SMHSci in this weeks @ScienceMagazine. Wow! #mindblown Good times back @ZerialLab @mpicbg ! Original paper: rupress.org/jcb/article/221/… Feature: science.org/doi/10.1126/scie…

Endosomal escape of delivered mRNA from endosomal recycling tubules visualized at the nanoscale

Paramasivam et al. compared the endosomal trafficking of six LNP-mRNA formulations. LNP-mRNA accumulates in large endosomes impaired in acidification and u

rupress.org
Stella Hurtley@SMHSci18 Mar 2022
Check out my choice this week in @ScienceMagazine rupress.org/jcb/article/221/… @ZerialLab
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This review is the starting point of a new adventure for me! Stay tuned for more organelle dysfunction in neurodegeneration in the near future.
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We hope you will enjoy reading. Thanks to Sarah-Maria @FendtLab and Markus @RalserLab for the invitation and for editing this special issue.
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