@borgesaugust

Biological Physics and tissue dynamics | Postdoc @PaluchLab at @PDN_Cambridge | PhD @LMU_Muenchen 🇦🇷

 Cambridge
Joined September 2010
  • Tweets30
  • Following484
  • Followers134
Can we use morphology and dynamics to understand the mechanical state of tissues better? Here is a brief thread about our recent mini-review with @Osvaldo_Chara !
Osvaldo Chara@Osvaldo_Chara11 Dec 2024
Excited to share this mini-review on dynamic mechanical stress inference of tissues written with @borgesaugust! doi.org/10.1042/BST20230225 (1/8)

Peeking into the future: inferring mechanics in dynamical tissues

Cells exert forces on each other and their environment, shaping the tissue. The resulting mechanical stresses can be determined experimentally or estimated computationally using stress inference...

portlandpress.com
1
9
505
🧵 New protocol out in @STARProtocols! We present a step-by-step guide for inferring mechanical stresses in tissues using ForSys, by @BorgesAugust, @hey_jero, @CeccarelliAS, @gbventur, @ksedzinski, @LopezSchier365 & @Osvaldo_Chara cell.com/star-protocols/full…
1
7
1
15
2,207
Curious about how to achieve organ-wide #regeneration through locally controlled cell proliferation? Check out our latest computational adventure addressing this problem in the #neuromast within the #zebrafish lateral line. doi.org/10.1016/j.jtbi.2026.… (1/9)
1
3
7
136
Delighted to get this published nature.com/articles/s41586-0… now @Nature Ethylene regulates root cell mechanics in compacted soils @UniofNottingham @UoNBiosciences @UoNresearch @UKRI_News in collaborations with Staffan Persson and Wanqi Zhang.
Rice roots showing swelling response in hard soil!

ALT Rice roots showing swelling response in hard soil!

10
46
3
219
12,796
Thrilled to have contributed to this @Nature study on ethylene and cell wall mechanics in root compaction responses — led by brilliant colleagues! Featuring Jiao Zhang, Lucas Peralta Ogorek, @borgesaugust, @pandeybipink, Staffan Persson, Wanqi Zhang, Malcolm Bennett & more.
Bipin Pandey@pandeybipink26 Nov 2025
Delighted to get this published nature.com/articles/s41586-0… now @Nature Ethylene regulates root cell mechanics in compacted soils @UniofNottingham @UoNBiosciences @UoNresearch @UKRI_News in collaborations with Staffan Persson and Wanqi Zhang.
Rice roots showing swelling response in hard soil!

ALT Rice roots showing swelling response in hard soil!

2
5
327
We are looking for: PhD Student (starting as Research Assistant) and Postdoctoral Researcher in Stem Cell Biology and Mechanobiology. Please RT💕 🔗 About our lab: renew.science/principal_inve… 🎓 PhD position: jobportal.ku.dk/phd/?show=15… 🧪 Postdoc position: jobportal.ku.dk/videnskabeli…
11
141
7
461
59,255
Our ForSys method to infer the mechanical state of a tissue in space and time is published now in @iScience_CP! cell.com/iscience/fulltext/S… (1/10)
1
4
6
268
🔬Curious about how to achieve an organ-wide regenerative response through locally controlled cell proliferation? Check out our latest preprint, which computationally addresses this problem in the neuromast within the zebrafish lateral line. biorxiv.org/content/10.1101/… (1/9)

Local control of cellular proliferation underlies neuromast regeneration in zebrafish

Biological systems are never at equilibrium but maintain stability despite perennial external disturbance. A prime example is organ regeneration, whereby despite intrinsically stochastic damage,...

biorxiv.org
1
11
2
30
3,522
So excited to share our new preprint! 🎉 In this project, we're revisiting enhancer modularity with quantitative approaches in Drosophila 🪰🧬 Summary in the thread below. ⬇️ biorxiv.org/content/10.1101/…

Entangled and non-modular enhancer sequences producing independent spatial activities

The modularity of transcriptional enhancers ( [1][1], [2][2] ) is central to our understanding of morphological evolution, as it allows specific changes to a gene expression pattern component,...

biorxiv.org
1
4
1
5
780
Excited to share this thread on stress inference! Thanks for the opportunity, @EpiMechFC #EpithelialMechanics
epithelial mechanics fan club@EpiMechFC11 Aug 2024
Mechanical forces can affect the way tissue grows. Ideally, we want to characterize them without interfering with the processes we are studying. Is there a way to achieve this? I am @borgesaugust. Welcome to my stress inference tutorial! #EpithelialMechanics
4
26
1,620
We uploaded a short tutorial on using ForSys (biorxiv.org/content/10.1101/…), our stress and pressure inference tool, with @Osvaldo_Chara. Check it out on Medium! medium.com/@borgesaugusto/fo…

ForSys: non-invasive stress inference from time-lapse microscopy

During tissue development and regeneration, cells interpret and exert mechanical forces that are challenging to measure in vivo. Therefore, stress inference algorithms have emerged as powerful tools...

biorxiv.org
3
5
1
17
1,866
Borges, A., Miranda-Rodriguez, J. R., Ceccarelli, A., Ventura, G., Sedzinski, J., Lopez-Schier, H., & Chara, O. (2024). ForSys: non-invasive stress inference from time-lapse microscopy. bioRxiv, 2024-05. biorxiv.org/content/10.1101/…
13
1
42
9,760
ForSys: non-invasive stress inference from time-lapse microscopy biorxiv.org/cgi/content/shor… #biorxiv_sysbio
2
3
282
Our software, ForSys, is finally out as a preprint! I am thrilled to have worked on this fantastic story. I want to thank @hey_jero, @CeccarelliAS, @gbventur, @ksedzinski, Hernán López-Schier, and @Osvaldo_Chara for this amazing journey. Stay tuned for more!
Osvaldo Chara@Osvaldo_Chara29 May 2024
We present ForSys, a new method to portray the mechanical state of a tissue in space and time!! biorxiv.org/content/10.1101/… (1/11)

ForSys: non-invasive stress inference from time-lapse microscopy

During tissue development and regeneration, cells interpret and exert mechanical forces that are challenging to measure in vivo. Therefore, stress inference algorithms have emerged as powerful tools...

biorxiv.org
2
4
1
18
1,720
Interested in how multicellular cell rotation is controlled? Out from @LopezSchier’s lab in @Dev_journal! Check doi.org/10.1242/dev.200975! If you want to know about the minimal mathematical model that the great @borgesaugust and I introduced, this is your thread! (1/8)

Quantitative videomicroscopy reveals latent control of cell-pair rotations in vivo

Highlighted Article: Relative intercellular asymmetry is a crucial factor underlying the robustness of persistently directional collective cell rotations in vivo.

journals.biologists.com
1
4
14
1,447
When is it OK to assume a tissue as infinite? Read the last article from Chara's lab by @CeccarelliAS , @borgesaugust and @Osvaldo_Chara about spatiotemporal distribution of morphogens! royalsocietypublishing.org/d… (1/9)

Size matters: tissue size as a marker for a transition between reaction–diffusion regimes in...

Abstract. The reaction–diffusion model constitutes one of the most influential mathematical models to study distribution of morphogens in tissues. Despite

royalsocietypublishing.org
Royal Society Publishing
@RSocPublishing27 Jan 2022
Size matters - tissue size as a marker for a transition between reaction–diffusion regimes in spatio-temporal distribution of morphogens: ow.ly/lHS350HFrzc #RSOS #OpenAccess #ComputationalBiology #biophysics
3
14
16
The deadline for applying to the PhD position in Nottingham is tomorrow!
Osvaldo Chara@Osvaldo_Chara4 Jan 2022
Are you interested in pursuing a PhD investigating how mechanical interactions shape tissue morphogenesis during development and regeneration? Do you love mathematical modeling/image analysis? (who doesn't, right?) Contact me to work with us in Nottingham or just apply:
7
7
Congratulations to @_CamiloRG, and @TatiSandGuz for their new adventure in @DevelopmentalDy exploring post-embryonic development and aging of the appendicular skeleton in axolotls. Collaboration with @CeccarelliAS and @Osvaldo_Chara from @SysBioGroup anatomypubs.onlinelibrary.wi…
5
9
When is it OK to assume a tissue as infinite? Read the last preprint from Chara's lab by @CeccarelliAS @fiisau and @Osvaldo_Chara about spatiotemporal distribution of morphogens! biorxiv.org/content/10.1101/…

Size matters: An analytical study on the role of tissue size in spatiotemporal distribution of...

The reaction-diffusion model constitutes one of the most influential mathematical models to study the distribution of morphogens spreading within tissues. Despite its widespread appearance, the role...

biorxiv.org
2
6
14
Curious about how cell proliferation and cell recruitment interact? Check out our new modelling and experimental adventure in Drosophila wing development by @Osvaldo_Chara and @H_Ariel_Alvarez in collaboration with Nahmad´s Lab published in @Dev_Bio_Journal !
H. Ariel Alvarez@H_Ariel_Alvarez21 May 2020
A dynamic cell recruitment process drives growth of the Drosophila wing by overscaling the vestigial expression pattern. @Osvaldo_Chara @SysBioGroup Our work with Nahmad´s Lab sciencedirect.com/science/ar…
1
1
3
Load more