Chyme reinfusion using The Insides® System to reduce parenteral nutrition dependence in type 2 intestinal failure: multicentre randomized clinical trial (REINFUSE)
➡️doi.org/10.1093/bjsopen/zrag…
Type 2 intestinal failure due to double enterostomy or enterocutaneous fistula entails dependence on parenteral nutrition (PN), and chyme reinfusion therapy (CRT) has not been evaluated in a randomized trial. This trial randomized 39 PN-dependent adults at 12 UK and US centres 2 : 1 to device-assisted CRT plus standard care or standard care alone. At 30 days, 8 of 26 active participants (31%) achieved a ≥ 50% PN calorie reduction versus none of 13 controls (P = 0.035; prespecified threshold P < 0.025). At 60 days, 10 active participants had ceased PN, with an acceptable safety profile.
👏👏👏Tony Milne, Simon Lal, Arun Abraham, Kirstine Farrer, Jonathan Evans, Kathryn Thomas, Carolynne Vaizey, Simon Gabe, David Layfield, Neena Randhawa, John Rogers, David F Mercer, Liran Barda, Robert E Carroll, Martin D Rosenthal, Syed-Mohammed Jafri, Chris Frampton, Dermot Burke
#SoMe4Surgery #MedTwitter #SurgEd #Surgery @BJSAcademy @BJSurgery #RCT #EvidenceBasedSurgery #IntestinalFailure
Garth Sutherland retweeted
Fantastic discussion at our complex IBD webinar series @ibdpouchsurgery
Great presentations from @nhsUHLG team led by Mr Shobhit Arya
Grateful to Ms Orsalia Mangana for hosting this meetings and to all our faculty and delegates
Garth Sutherland retweeted
🚨 WOW!! Argentina President Javier Milei just walked up to the mic at the United Nations and RIPPED THEM TO THEIR FACES
"It's become a USELESS organization whose only purpose is to sustain a caste of fatefully arrogant PARASITES masquerading as well-intentioned bureaucrats!" 🔥🔥🔥
"The alleged 'defenders of human rights' have sheltered bloodthirsty dictatorships and regimes that stone women in the streets!"
"Good people do not think about controlling the lives of their fellow human beings."
"Those who were supposed to guarantee collective security and human rights failed in their task. Instead, they allowed chaos, violence and international terrorism to flourish."
YOU ARE A LEGEND, @JMilei 👏🏻
Seems like President Trump and Milei both had the BEST speeches at the UN. Pure nationalist first, globalist last
The UN is filled with hypocrites who cozy up to Islamism and 3rd world mass migration, while attacking the nations who want to retain their own borders and their national interests
Those days are over. MAGA! 🇺🇸🇦🇷
Garth Sutherland retweeted
📣 New customer announcement: 𝗔𝘀𝘁𝗿𝗮𝗹 𝗠𝗮𝘁𝗲𝗿𝗶𝗮𝗹𝘀 books up to 𝟭𝟬𝟬 𝗺𝗶𝗰𝗿𝗼𝗴𝗿𝗮𝘃𝗶𝘁𝘆 𝗳𝗹𝗶𝗴𝗵𝘁𝘀 𝗼𝗻 𝗔𝘂𝗿𝗼𝗿𝗮, starting in 2028 ✈️
Read the announcement: dawnaerospace.com/latest-new…
Garth Sutherland retweeted
A full stoma bag in traffic jam can be a genuine source of anxiety.
For selected patients using The Insides System for chyme reinfusion, being able to empty and reinfuse without needing immediate bathroom access can make that situation feel very different.
Garth Sutherland retweeted
A defunctioning stoma protects the anastomosis, but the distal bowel may remain unused for months.
Once healing is confirmed, chyme reinfusion can restimulate the bowel before reversal, helping patients and care teams know what to expect after closure.
Contact us to learn more.
Garth Sutherland retweeted
Our new review out today on Testosterone, Creatine, HMB & other anabolic agents in ICU.
❓ Do you use creatine, testosterone, HMB or oxandrolone in your ICU or hospital patients?
🔖 journals.lww.com/co-critical…
#ICURehab #FOAMcc #CriticalCare #ICUNutrition
@ICUnutrition
Garth Sutherland retweeted
Join the 13th Biennial Congress of ASEAN, Penang (24–26 April).
Clinical insights from Dr Hans Alexander Mahendran and Prof. Cheong Wai Kit, alongside patient perspectives from Muhamad Safwan Ishak, as access expands in Malaysia with Medi-Life and The Insides System.
Garth Sutherland retweeted
Too much FUD on Rocket Lab these days. Let's go back to the roots - The Peter Beck story.
If you’re an $RKLB OG, consider this a reminder of what you own.
For the newcomers & doubters: This is the part that makes Rocket Lab different.
1/🧵
Garth Sutherland retweeted
We’re proud to announce that The Insides System is now registered with the Malaysia Medical Device Authority (MDA) 🇲🇾 — a key step in expanding chyme reinfusion therapy across Southeast Asia.
For enquiries in Malaysia, contact @MediLifeCares ([email protected])
Garth Sutherland retweeted
We’re at #MUGIS2025 (17–18 Oct, Kuala Lumpur) with Medi-life Technologies to showcase our chyme reinfusion tech! Proud of Hospital Sultanah Aminah presenting Malaysia’s first clinical case. Visit Booth S05!
#UpperGI #ClinicalNutrition
Garth Sutherland retweeted
Proud to be featured among New Zealand innovators transforming global health.
At The Insides Company, we’re advancing chyme reinfusion therapy to set a new standard of care for patients with intestinal failure.
Appreciation to @NZTEnews for highlighting our work.
Garth Sutherland retweeted
Proud to share our first Malaysian patient case study, presented at MUGIS 2025 .
A 31-year-old recovered from typhoid-related small-bowel obstruction using The Insides System.
Our sincere thanks to the Hospital Sultanah Aminah & Hospital UKM team for sharing their experience.
Garth Sutherland retweeted
A new open-access case report in the New Zealand Medical Journal describes the first use of The Insides Channel — chyme reinstallation from one stoma to a distant stoma.
Read the paper here: nzmj.org.nz/journal/vol-138-…
Garth Sutherland retweeted
We’re one day away from EFOA 2025 in Copenhagen!
Join us Friday 29 Aug at 11:40am to hear Prof. Ian Bissett present “Chyme reinfusion for entero-atmospheric fistula: challenges, lessons, and outcomes of a national experience.”
Connect with us at our stand with @kebomed A/S.
Garth Sutherland retweeted
We’re excited to support First Medical Company at #SAGES2025 in Durban!
📅 31 Jul–3 Aug
📍 Coastlands Umhlanga
🚩 Stand 20
Explore The Insides® System & The Insides Neo for chyme reinfusion therapy in high-output stomas & fistulas. #RefeedTheWorld
Garth Sutherland retweeted
We had a great lecture on LARS and its complex treatment strategy by Dr Özdal Ersoy
@MemorialBahçelievlerHospital
Pelvic floor and bowel health Unit🧬🔬✨
➡️What is Low Anterior Resection Syndrome (LARS)?
💡 After surgery to remove part of the rectum (commonly for rectal cancer), some patients experience a group of symptoms known as LARS.
🧻 Symptoms may include:
🔹 Urgency (needing to rush to the toilet)
🔹 Increased frequency of bowel movements
🔹 Incontinence (accidental leakage of stool or gas)
🔹 Fragmented stools
🔹 Difficulty emptying the bowel completely
🧠 Why does it happen?
Surgery can disrupt the rectum’s function as a reservoir. Additionally, nerve damage or loss of the natural defecation reflex can alter bowel habits.
🌟 Who is at risk?
Patients who have undergone:
✅ Low anterior resection
✅ Radiotherapy
✅ Total mesorectal excision (TME)
✅ Anastomosis close to the anal canal
🎯 Management options:
✅ Diet modification
✅ Pelvic floor rehabilitation
✅ Medications
✅ Transanal irrigation
✅ Sacral nerve stimulation (in selected cases)
🩺 Early recognition and multidisciplinary support can make a huge difference in quality of life. Let’s raise awareness!
—
🔬 Low Anterior Resection Syndrome is common but manageable.
📌 Education and support are key.
#ColorectalSurgery #LARS #RectalCancer #PelvicFloor #SurgicalRecovery #ColorectalAwareness #GastrointestinalHealth #SurgeonLife #OncologySupport #LowAnteriorResection
@MemorialSaglik @escp_tweets @TKRCD_ @Genc_TKRCD @TGDGastro @onkolojidernegi @ASCRS_1 @faycagultekin @SezaiLeventoglu @cihangirakyol @mustafaoncel @drleylaozer @doktorcivanim @BoroBag @CannSaracoglu @mertgungor @ProfDryildizI @harputluogluhakan
Garth Sutherland retweeted
Trends in surgical treatment for ulcerative colitis in the era of biologics – A population-based study using German diagnosis-related groups data - @SurgJournal surgjournal.com/article/S003…































