@zaknight

The Neurobiology of Homeostasis.

 San Francisco
knightlab.ucsf.edu
Joined December 2010
  • Tweets699
  • Following844
  • Followers3.2K
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Talking with HS students from the Mission Bay Hub about obesity and curiosity-driven science. With help from @TruongLy18 and an ob/ob mouse. @SFUnified
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Kivanc Birsoy@KivancBirsoyOct 22
Our graduate student @YuyangLiu1996 just opened his lab as a Sandler Fellow at @UCSF . Looking forward to many discoveries from Yuyang, an incredibly creative scientist: physiology.ucsf.edu/content/… @RockefellerUniv
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Tony Zador@TonyZadorOct 7
Maybe if we instilled a real fears into AI agents, like a fear of hacking or of building bioweapons, instead of just telling that they shouldn't be naughty.
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Rachel Essner deserves huge congrats for this opus on integrative brain-to-body signaling in the parabrachial nucelus. Now improved and published! Check it out.
Rachel Essner@RachelEssnerSep 17
I’m thrilled to share the published version of our paper, now officially out in Neuron! Read it here: authors.elsevier.com/c/1no8J… One updated highlight: with new analyses we now show how functionally-defined groups of neurons putatively overlap with molecular cell types in LPBN
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Mazen Kheirbek@mazen_kheirbekSep 14
Our new review is out now on the ventral hippocampus, highlighting a large body of recent work, from the information it represents to how internal state shapes its activity to how its circuits influence behavior.
Nature Rev Neurosci@NatRevNeurosciSep 14
The ventral hippocampus: computations, circuits and functions — a Review by Jeremy S. Biane, Julian Wagner-Carena & Mazen A. Kheirbek @jeremy_biane @jawagnercarena @mazen_kheirbek nature.com/articles/s41583-0…

The ventral hippocampus: computations, circuits and functions

Nature Reviews Neuroscience - Recent years have witnessed major advances in our understanding of the distinct functional and computational roles of the ventral hippocampus (vHPC). Mazen Kheirbek...

nature.com
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Arjun Raj
@arjunrajlabSep 14
If you are preparing a presentation, by far the most effective, concrete tip is to ensure each slide title is a complete sentence. Subject, verb, object. That ensures each slide has 1. at least one point, 2. no more than one point—i.e., each slide has exactly one point! :)
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Excited to share a preprint of my postdoc work in the @zaknight lab! We recorded the natural activity of neurons in the brain's "nausea center", the area postrema (AP), including the direct targets of major weight loss drugs like semaglutide. biorxiv.org/content/10.64898…

Functional segregation of body-brain signals in the area postrema

Nausea arises from activation of specialized neurons in the area postrema (AP)[1][1]–[8][2]. The AP also mediates much of the satiety produced by GLP1R agonists[9][3]–[12][4], suggesting a broader...

biorxiv.org
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Michael Krashes@michael_krashesMay 22
New work from Claire Gao in @NatMetabolism uncovering the intracellular signaling mechanisms by which semaglutide drives weight loss in the brain. This study goes DEEP into how GLP1R signaling works inside hindbrain neurons. 🧠⚡ nature.com/articles/s42255-0…
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Pancreatic cancer is one of the most dire diagnoses in medicine with few available treatments. Until now, thanks to university research, including @UCSF scientists, and federal investment in science research. Read about this huge breakthrough via @nytimes nyti.ms/4wfziXs
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Kivanc Birsoy@KivancBirsoyApr 17
Our new work by @shanshanliu1218 and @gadmark addresses a fundamental question: how does ER maintain its unique oxidizing environment, while rest of the cell is reducing? Here, we identify SLC33A1 as the major ER GSSG exporter in mammalian cells. nature.com/articles/s41556-0…

SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis

Nature Cell Biology - Liu, Gad et al. develop an approach to purify the endoplasmic reticulum and integrate genetic, structural, molecular and cell biological analyses to identify SLC33A1 as an...

nature.com
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📢🎉@hhmi_science competition for the next cohorts of #HannaGray Fellows and #FreemanHrabowski Scholars opening 11/3/2026. Senior postdocs and faculty within 7 years of appointment. Up to $10M over 10 yrs, + salary & benefits. Spread the word and consider applying! bit.ly/4vhC0LA
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Scientific publishing needs to change. In a new preprint, HHMI President Erin O'Shea and Bodo Stern argue that the incentives are misaligned. Researchers should be evaluated on what they choose to share, not what journals select. I’m proud that @hhmi_science is leading the way. Read the preprint here: doi.org/10.5281/zenodo.19600…
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We have an opening for a Lab Manager position in my group at UCSF. Consider joining us! Link in reply.
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hhmi.wd1.myworkdayjobs.com/e…
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Jonathan Kipnis 🟦
@jonykipnisMar 16
Why do journals require deposition of large datasets, but not the deposition of newly generated transgenic animals to publicly accessible repositories? The nonsense of published mouse lines not being shared must end, and journals can help drive this change.
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Yoav Livneh@Yoav_LivnehFeb 13
New lab preprint! Can we study conscious perception of gut sensations in mice to reveal its neuronal basis? Can we train mice to report their gut sensations? Omer Rafael and Stav Shtiglitz in the lab teamed up to discover that…YES! Thread…1/6 biorxiv.org/content/10.64898…
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Doris Tsao
@doristsaoJan 29
Registration for the one and only @AsconaCircuits meeting is now open! This is my favorite systems neuroscience meeting...talks and discussions here are at a different level of intensity, and cover everything from flies to humans, hunger to thought. Register! asconacircuits.org/
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This will be a great meeting - register now to join us in Ascona in September.
Ascona Circuits@AsconaCircuitsJan 4
Registration for the Ascona 2026 Meeting is now open. Go to asconacircuits.org to submit your abstract and register for the meeting! We are looking forward to seeing you in Switzerland this September! Ascona Meeting Organizers
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Waggoner Lab@LabWaggoner18 Dec 2025
Estrogen tunes a cross-talk between hormone-secreting cells in the mouse gut to regulate visceral pain science.org/doi/10.1126/scie… science.org/doi/10.1126/scie… @ScienceMagazine @hollyingrahamSF @UCSF preview by @FlyGutLab
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This new study from @shenliang_yu describes a genetic screen to identify nutrient sensors that control release of GLP-1 biorxiv.org/content/10.64898…

A genetic screen in enteroendocrine cells reveals mechanisms that control protein sensing and GLP-1...

Enteroendocrine cells (EECs) are the principal nutrient sensors in the gastrointestinal (GI) tract and release hormones such as glucagon-like-peptide 1 (GLP-1) that modulate GI function and appetite....

biorxiv.org
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New work from @Nikos_Chatziris describes a method for genetically tagging neurons that respond two different stimuli. biorxiv.org/content/10.64898…
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