Gut First

GutFix is live on IOS. No more hours trying to get info only to get half-baked hallucinations (cough cough GPT), No more spending hours on PubMed trying to find the thing that'll work for you, It took well over 1000 hours of knowledge to train, and you can get an answer in 30s: gutfix.ai/get-gutfix

Kill your favourite probiotic THEN consume it to heal your gut. L Reuteri can sometimes cause bloating or histamine flareups when live, Once dead however it can still bind to nickel, support your gut lining and suppress pathogens. In fact for anyone with SIBO I'd favour this over LIVE reuteri any day of the week, simply due to it's safety profile and non-problematic nature.

What happens when the first plan, the first protocol or the first approach doesn't work? Where do you go? What do you think? What do you do? Me and @BerrabeTommy discuss exactly this today in our podcast: open.spotify.com/episode/6QX…

Also simply listening to or singing along to music can raise secretory IgA, To be honest putting on some music to defend against endotoxins is as chill as it gets gut health wise.

A carrot is not a valid antimicrobial. A carrot is however highly fermentable (hello bloating), Carrot fiber doesn't possess the same LPS binding properties as MODIFIED citrus pectin. 95% of the benefit you're feeling from the carrot salad is just whatever you're putting on it, Coconut oil and monolaurin is a valid antimicrobial and biofilm agent, Vinegar has it's own benefits for the gut known for thousands of years. The carrot is just a handy carrier for the therapeutic dressing you put on it.

Literally anything is better for acid reflux than acid suppressing meds: They put Aloe Vera head to head and found it just as if not more effective (with less/no sides), DGL (a type of liquorice) outperformed antacids not by suppressing acid, but by repairing the mucus lining. Melatonin often matches stomach acid suppressors via tightening the LES, showing again the acid isn't the issue. In fact if you dig deeper into the research you'll almost always find suppressing acid is the worst intervention for gut health, Besides being ridiculously stupid compared to these other interventions you also get the risk of infection and subsequent SIBO increasing, You also impair basic digestion function. And the worst part is with PPI's there is no end game, With reparative work there is.

2 weeks of daily matcha and one butyrate producer doubled (+108%) with another up 76%. These bacteria make butyrate, the compound that when given directly: - Lowered abdominal pain - Reduced bloating - Lowered urgency of bowel movements Whole leaf gives the insoluble fiber that feeds them + high EGCG that can suppress pathogenic competitors. Cheap, easy, and one of the few trends I actually run with daily.

Just a reminder your mucus lining is 95-98% water, If you like an intact gut lining it's probably in your best interest to hydrate. If you're dehydrated you can also enjoy: - Slow gastric emptying - Lowered stomach acid - Slow motility/transit time - Increased leaky gut So I would say get your liquids in, I personally like isotonic marine plasma but take your pick as to how to hydrate, Be mindful also dehydration in states of gut distress could be theoretically even more harmful leaving your more susceptible. Who would of thought hydration is important.

Even more slept on tools for gut health: - PEA (for mast cells & lining) - Yoga Nidra (crushes chronic stress) - Serum-Derived Immunoglobulins (binds toxins) - Lactospore (especially for diarrhea) - Boswellia - Deglycyrrhizinated licorice (DGL) - Isotonic Marine Plasma

PEA was able to reduce the explosion of mast cells by up to 50%, For context those mast cells exploding are what often leads to intense, urgent and watery diarrhea. When mast cells burst they release their contents into the surrounding area, Histamine, destructive proteases and spasm inducing lipids all bind to local tissues causing the rapid flushing response in IBS-D. They also open up and damage the gut barrier leading to a sudden influx of water which you experience as loose stools, Then from there since mast cells live so close to nerve endings these inflammatory compounds bind to pain receptors. The irritated nerve endings release Substance P which when it comes into contact with mast cells causes further degranulation, Now back to the histamine, as more mast cells explode more histamine is in the surrounding area. This activated the h4r receptors, Now what makes this such a pain is that this activation leads to more mast cells and more sensitive mast cells drawn to the area. Okay by now you can see how this loop gets pretty bad, explosions leading to more explosions (both internally and in your bowel movements), So with PEA stabilising the mast cells you're helping to break the loop of things getting worse. Personally I like to pair it with black seed oil and quercetin, which have unique binding affinities for the h4 receptors again helping to stop the loop getting worse. (They also stabilise mast cells so win-win) So yeah histamine isn't just purely a allergy molecule, it's often what drives IBS-D and chronic loose stools that seem to evade everything you throw at them.

If you can't have 20 atomic chicken wings without violent diarrhea are you even healed?

Take blood from a cow. Spin it real fast to separate the plasma, Extract the antibodies. Spray dry it into a powder. This powder: - Protects you against endotoxin/LPS by binding to it - Feeds butyrate producers leading to a stronger gut - Reduces Diarrhoea via stabilising the lining - Improved COVID recovery speed by up to 2x - Delayed/Lowered recurrence of SIBO - Increases certain beneficial microbes by up to 3.5x You can buy it online, even though it's expensive it's one of those supplements worth forking out for, You'll find it under Immunolin. in products like designs for health IgGI Shield, Better GI (when it's finally back in stock) and Mega IgG2000 powder. If you're running an antimicrobial protocol and worried about your lining, know your lining is an issue or have IBS-D this is one of the highest value interventions you can try.

I agree with the sentiment here that supplements as band-aids aren't going to fix your issue, But often the only way out of an inflamed gut is supplementation. If you have a high microbial load and especially something like SIBO you need to address both the cause and the current state, Neither of which can reasonably be done without some degree of supra-dietary compounds. The real shift is that of going from reactive to proactive, from defensive to offensive, You'll simply never reach the therapeutic value of a exotic probiotic yeast like S Boulardii by changing your diet. You'll never repair the lining to the extent of butyrate, zinc l-carnosine, lactoferrin and PEA by drinking bone broth. You'll never kill or suppress a microbial overgrowth by sprinkling extra herbs on your food. At some point we have to accept the mess that we are in cannot be solved using the same paradigm that got us here in the first place, That being that dietary interventions alone will save us. Now take your pick, whether it is natural extracts, semi-synthetics or whatever your flavour of medicine is, Choose a paradigm that guarantees you'll get where you want to be with YOUR health, not an idealistic road to where someone else wants to go.

e coli german solider gut bacteria probiotic: gutfirsthealth.substack.com/…

Okay so you're not interested in the e coli german soldier gut bacteria probiotic? Let's replicate mot if it's effects without the big scary e. coli: - Visbiome GI Care (This hits the mechanisms of healing the gut lining, calming inflammation and crowding out pathogens) - S Boulardii (Another microbe that crowds out pathogens, neutralises bacterial toxins, and acts as a decoy so pathogens bind to it and get flushed out) - Lactoferrin (Binds Iron so pathogens can’t feed and overgrow utilising it, Apolactoferrin is best) - Bacillus Subtilis (Boosts your bodies own antimicrobial peptides whilst producing it’s own unique ones) All the benefits, none of the e coli german solider gut bacteria probiotic. Check out the original post though in the comments if you want to learn the story behind the e coli german soldier gut bacteria probiotic...

I've posted about a million times on how I address SIBO, but it seems some people still get it wrong, So instead I put together an article on how I would NOT address SIBO. That way as long as you avoid the pitfalls your chance of success is higher, As always these longer articles are on my substack, the link to which will be in the comments.

This weeks episode we are going deep into how Tommy approaches working with clients, And more importantly what lessons you can learn from it. Listen to me and @BerrabeTommy discuss this here: open.spotify.com/episode/0KZ…

There are a fair few interventions and knowledge bombs in here for free: gutfirsthealth.substack.com/…

You can also observe Diarrhea Body Langauge™ Seriously I can often tell when walking through a busy town centre or being in a closed setting who has comfortable digestion and who will make a run for the bathroom at any second, Is this really practical? No. But I wrote a guide on pretty much every subtype of diarrhea and some basic interventions/trials for each, So I may or may not have had to drop that tidbit so you'd give it a read and potentially try said things out. As always it'll be down under this post. Enjoy and keep me updated with results.